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Protection from and Potentiation of Cocaine with Deprynl and Tyrosine.

2CEECS

2CEECS

Bluelighter
Joined
Mar 8, 2007
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Berkeley, CA
Hey all,

I'm preparing for what has become my roughly bi-yearly indulgence in a modest amount of cocaine. This time, I'm curious about using Deprynl and L-Tyrosine to my advantage. I'm looking for both theoretical and empirical advice.

First, I realize that sustained use of Deprynl appears to reduce the effects of cocaine. I speculate this is simply the brain becoming more accustomed to the affects of dopamine and down-regulating it, though this may not be correct. But what if Deprynl were started just shortly prior to dosing cocaine? Wouldn't the MAO-B inhibition help protect the brain from undue oxidative stress in the breakdown of dopamine?

With Deprynl in place, this makes preloading with L-Tyrosine a reasonably sane idea. Unprotected, I would not be thrilled about putting more oxidizing material into my brain in preparation for a sustained release, but the protection offered by Deprynl could make that potentiation method much safer.

Finally, the comedown could be similarly attenuated by postloading more L-Tyrosine, still under the protection of Deprynl until back to normal functioning.

Any opinions or experiments with either, or both, components of this plan? Thanks!

PS -- Something that could speculatively be added to this would be a CYP34A inhibitor. Any comments? Aside from grapefruit, what are your favorite non-prescription substances that can be used, and how do they compare in effectiveness?
 
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Indeed, as I mentioned, I am aware that Selegiline/Deprynl has been more often cited as attenuating cocaine's effects rather than boosting them. But, in the study you provide, patients were given Selegiline for a full week beforehand; I am considering applying a transdermal patch a number of hours beforehand. Also, the Selegiline is not likely to produce a huge boost in effect, but rather reduce oxidative stress--it is the "protection" part of the equation.

Anyone care to speculate how Deprynl reduces the subjective effects of cocaine? Will that only occur after a relatively sustained course of it, allowing the brain to adjust a bit to abnormally high dopamine levels due to reduced metabolism of the neurotransmitter?
 
Please be careful when combining selegeline with stimulants. It increases the risks of stimulant use.
 
Why are you jumping to selegiline out of all things for protection of oxidative stress? Just drink some green tea and you'll be just as fine, if not better. And if you smoke weed, THC is a better antioxidant than many.

Just to note, Selegiline + Tyrosine alone has some VERY notable stimulant effects, and many of them peripheral (I compared my own experience with that combo to meth, but YMMV). If that doesnt seriously hurt you, I assume it will make your experience a horrible one.

But I could be wrong.
 
Thanks for the replies.

F&B, indeed true about the cardiotoxic effects. While protection from all negative effects would be awesome, that's probably between impractical and impossible--but some is better than none. Clearly, I also worry about nasal tissue necrosis. These clearly damaging and unavoidable effects are the reason I have made cocaine a very rare instrument of my exploration.

Jamshyd, I jump to Selegiline because it targets the particular problem--metabolism of dopamine leading to oxidizers. While antioxidants would go a long way to help the problem, an MAO-B inhibitor limits it at the root. I remain curious about this combination, but an antioxidant cocktail could serve some of the same purpose.

What about CYP3A4 inhibition?
 
Honestly if you blow coke twice a year you have very little to worry about IMO. Just take some alpha lipoic acid (best antioxidant for rec drug usage) and go light on the alcohol consumption. If you are worried about comedowns then please avoid stimulant use. And as was mentioned above cannabis would also be good at the tail end of the night if you can handle yourself without whigging out from paranoia.
 
You don't need to use the THC when you're high. You can wait hours or even a day later before using it and you should get adequate protection.

I doubt you'll have any problems from that seldom of use.
 
I understand I should not expect any seriously noticable problems, but that doesn't mean I'm not concerned about damage I can't yet detect at a young age. I'm an engineer by trade, and so it is very natural for me to be concerned with problems that build up unseen until a certain point.

So, it seems agreed that simple ALA is adequate instead of Selegiline, even with Tyrosine supplementation. What about the usefulness of CYP3A4 inhibition, for reducing the metabolism of the cocaine itself? Obviously, this would just be to get more mileage out of the material.

Any experiences with either Tyrosine pre/postloading and dose recommendations (2g?), or CYP3A4 inhibition?

Thanks to all!
 
You should easily get enough tyrosine in your diet. It's a rate limited process, so supplementing doesn't really add anything at all unless your not eating enough.

The point isn't that you shouldn't expect "seriously noticable problems"- it's that with such infrequent use, you're not going to have any damage at all. This isn't like huffing glue.

Using that infrequently, and using in moderation when you use, you will have absolutely nothing to worry about- not because you can't notice it, but because it isn't going to do anything.
 
Thanks for both points. It seems peculiar to me that even a "brief" (in the scale of a lifetime) period of high oxidative stress would be entirely irrelevant, but I suppose that is not unusual provided sufficient antioxidant supply. However, of course, even slightly more chronic use that has exhausted antioxidants could begin causing real damage.

So, I will primarily utilize Tyrosine in postloading, with a bit of preloading for good measure; avoid the Selegiline; add in ALA and perhaps a few others; and am still curious about CYP3A4 inhibition.
 
2CEESCS, if you want the effects to last longer then just do more coke. If you are an infrequent user then its more risky to potentiate than simply redose. What if you start getting paranoid and anxious after you inhibited your enzymes? Then you have that much longer to wait it out. Not to mention significantly longer before any possibility of sleep despite the euphoria being long gone.

Ham-milton can you please explain why he can use the cannabis in the context of an antioxidant even a day later and still have it be effective? I thought oxidative damage was something that happened most intensely during the intoxication period and shortly after. Am I incorrect in this understanding? How could an antioxidant help the next day, and is the true of other drugs (alcohol for example) or at least other stimulants (specifically amphetamines).
 
theWorldWithin said:
2CEESCS, if you want the effects to last longer then just do more coke. If you are an infrequent user then its more risky to potentiate than simply redose. What if you start getting paranoid and anxious after you inhibited your enzymes?
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For most users, point taken!

However, I am equipped with downers of various types and strength; from the subtle melatonin and theanine, through diazepam and zolpidem, to quetiapine. Moreover, it will be carried out in a safe environment, and I am not prone to paranoia on this substance.

So, with that new information, why potentiate? Good coke is expensive, and I'd rather avoid putting more necrosis-causing mass up my nose if I can!
 
My 2c here would be to add some pre-loaded NAC in there as well, liver toxicity is as much of a concern with cocaine as cardio/neurotoxicity. NAC, ALA, Vitamin E, and a protein shake sounds good.
 
Re: CYP3A4

Well, cocaine IS listed as a substrate of that enzyme, but I have never really heard of anyone trying GFJ with it. Why don't you go ahead and try, and let us know? Citrus won't hurt you :)
 
^ Norcocaine is a very minor metabolite, it's mostly metabolized by plasma pseudoesterases. Probably explains why!

My 2c here would be to add some pre-loaded NAC in there as well, liver toxicity is as much of a concern with cocaine as cardio/neurotoxicity. NAC, ALA, Vitamin E, and a protein shake sounds good.
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My twopennethworth is to say don't do it unless you live next to a hospital A&E dept
 
Is there some greater risk with supplementing NAC? I always thought N acetyl Cystein was a good idea for drugs which are utter shit made up of more APAP than psychoactive (IE cocaine).
 
Went for it last night. More successful than expected!

2g Tyrosine;
1 glass grapefruit juice;
1g Vit C, 1kIU Vit E;
400mg ALA, 20,000IU (?) Beta-Carotene;

All taken roughly 1hr before dosing, with the Tyrosine being slightly over an hour, and the ALA being closer to the dose.

Started with a 0.1g line, and in short time, was very impressed with its strength. Felt astonishing, clearly unlike any other 0.1g starting line I've ever done.

However, shortly after this, I got a bit too curious and/or greedy and doubled the dose with another 0.1g. Given previous experience, this seemed to be a very reasonable amount at the time. I expected it to be very strong, but in short time I found myself in a strongly unpleasant state. It took a good 50 minutes to reach the point where I was comfortable re-attempting a pleasant high, though the true unpleasantness mostly passed within 15 minutes and became more enjoyable.

At this point, another 0.05g, taken in two small lines with a short pause between, was exactly what I needed. Excellent, powerful feeling from just 50mg of material!

This took me a clear 75 minutes until I even cared to try more, but this time I was able to boost with three 0.05g lines over the space of several minutes. At least two more strongly euphoric hours were yielded by that.

I stopped at this point to be able to get to sleep at a reasonable hour. Hopefully this information is useful to someone planning a similar experiment with multi-factor cocaine potentiation and protection.
 
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