High chance you will start to enter delirium territory at 250mg, also gets cardiotoxic the higher you dose. Why would you take this much promethazine unless you have a massive anticholinergic tolerance? It doesnt get better the more you take, 100mg would likely be enoughAm I safe taking over 250mg of promethazine in the span time of 4 hours? Im mixing it with kpins (for which I have a high tolerance)