Ive combined benzos and opis with pregabalin. Just 1 x 75mg pill of Preg definately boosts benzos, the combo makes me feel very sleepy, and I sleep much more on the combo than with the benzos alone. I dont take Preg very often so dont have a tolerance. I found it totally killed an opiate buzz, when i tried preg with odt. Some people say that o-dt was weak, IME it was nearly the same strength as oxy on a mg to mg comparison of the effects. I'd take about 150mg of each (not together!) to get a nice buzz.
Preg is very weird in its effects, and it's very dose related IMO. 75mg is relaxing and mood boosting, 2 or 3 and things start getting wobbly. 4,5 or 6 and things start becoming almost bad trip like for me, i start becoming anxious, loose control of my thoughts, and because of that i havent repeated the high (for me) doses.
First time I tried 1 preg I totally 'lost my legs', the same as when i first tried a benzo.
Pregabalin is also really fantastic as a muscular/nerve pain killer. I had a seized muscle/nerve in my shoulder a while back that was very painfull. Preg totally got rid of the pain, better than any other OTC meds Id tried or any opis id triued for that matter.