Precipitating morphine base from water solution of morphine sulfate! help Plz

[neverFAILEDtoFAIL]

Hello everybody. I hope everyone is well. Mods I didn't know where to put this so please move if appropriate. I really need this info for a friend's research experiment.

Ok please someone tell me if I have this right.. I've been doing the research and think I've got a way that'd work to precipitate calcium morphenate from a water solution ofmorphinesulfate. So hear goes. I'm trying to find the info for a friend who is doing the experiment.

Dissolve morphine sulfate ir tablets in appropriate amount of water maybe making it slightly acidic say pH 5. Let the solution sit for 5-10min. Then filter out all insoluble matter using*coffeefilters and vacuum filtration then a second filtration through filter paper.
Then once you've got a crystal clear solution add calcium hydroxide until a pH of 11.5 is reached. At this point the morphine sulfate should now be calcium morphenate soluble in basic solutions over 11.5. Correct?

Now here's where I think I get confused. Do you then add calcium carbonate to the solution until a pH of 9 is reached then cool in an ice bath and the ccrystals of morphine base precipitate out of the solution the colder it gets?
Then I'm thinking the last step is to vacuum filter the solution through even justcoffeefilters(they use tshirts and burlap bags for filtration in iraq).
Then let the crystals or powder of morphine base dry on the coffee filter over vacuum or let filter sit on layer of anhydrous magnesium sulfate til it's dry.

Please I desperately need to know from one of you chemistry geniuses and tell me if I've got it right or tell me the right way. My buddy really wants to do this and the possibly makehydromorphonefrom there.

Thank you so much for any help. I really need it and appreciate everything the people on this forum have done for me.


Sorry.*
Also the entire experiment is carried out at 70 degrees c and no higher no lower?correct?*

Until the last step of cooling to precipitate the base. Correct.

Neverfailedtofail

 

[sekio]

Why don't you just use a normal acid base extraction?

Calcium carbonate won't lower the pH of a calcium hydroxide solution either.

 

[neverFAILEDtoFAIL]

Can you explain to me how to alter this tek into an acid base extraction?

So once I have a solution of morphine sulfate at a pH of 5ish using citric acid I would then add what the calcium carbonate or the calcium hydroxide to get a pH of 11.5? Which one the hydroxide or the carbonate?

So then what I'd add an acid to lower the pH to 9 then cool to precipitate base?

I'm a little confused I thought the carbonate was needed to create the calcium morphenate. Wouldn't adding and acid make it a morphine salt of the particular acid also leaving it soluble in the solution. If it helps my friends extraction is from morphine sulfate ir pills not pods or anything.

Thanks for your help.

Peace love empathy
Neverfailedtofail

 

[neverFAILEDtoFAIL]

I'm going off the extraction used to precipitate morphine base from opium so Idk if that makes a difference.
It coming from the water soluble salt of meconic acid or the salt of sulfuric acid, I just don't know the difference. Does the ammonium chloride lower the pH to 9?

Baffled