• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Misc Powerful Opioid and Benzo Potentiator (I got one for you)

Status
Not open for further replies.
kokaino

kokaino

Bluelighter
Joined
Sep 8, 2007
Messages
2,937
Location
Detroit
There is something better than GFJ and cimetidine for potentiating benzos (except the 3-hydroxy group of lorazepam, temazepam, lormetazepam, and oxazepam). The antibiotic drug clarithromycin (Biaxin) is a drug that is an extremely powerful inhibitor of the CYP3A4 enzyme. This is the enzyme most responsible (by far) for the metabolism of just about all opioids and benzodiazepines. It comes in 500 mg tablets, taking 2 tablets (so 1000 mg) about 45-60 minutes before ingesting a benzo or opiate of choice and it would greatly potentiate it as it raises the levels of the drug in the body and makes the drug last longer.

I have tried it and it works better than anything I have ever tried to potentiate benzos or my methadone (or other opioids) with.

It is prescribed for chest infections. I generally get it when I go to the doctor and complain of a bad cough and a bit of chest pains. I usually get it along with a cough syrup.
 
kokaino said:
There is something better than GFJ and cimetidine for potentiating benzos (except the 3-hydroxy group of lorazepam, temazepam, lormetazepam, and oxazepam). The antibiotic drug clarithromycin (Biaxin) is a drug that is an extremely powerful inhibitor of the CYP3A4 enzyme. This is the enzyme most responsible (by far) for the metabolism of just about all opioids and benzodiazepines. It comes in 500 mg tablets, taking 2 tablets (so 1000 mg) about 45-60 minutes before ingesting a benzo or opiate of choice and it would greatly potentiate it as it raises the levels of the drug in the body and makes the drug last longer.

I have tried it and it works better than anything I have ever tried to potentiate benzos or my methadone (or other opioids) with.

It is prescribed for chest infections. I generally get it when I go to the doctor and complain of a bad cough and a bit of chest pains. I usually get it along with a cough syrup.
Click to expand...


Good info to know, do you know if its as easy to get up here in Canada?
 
Only one problem with this is that I believe you should not take antibiotics unless absolutely needed as your body may become immune to the antibiotic over time.
 
How do you use it to potentiate methadone? I'm on 130mg MMT myself and was just about to ask about potentiating methadone. In your experience, when is the best time to take this antibiotic? Also, how was your experience taking WGFJ or tagamet to potentiate methadone? Is it that the antibiotic works better, or that the GFJ and tagamet don't work at all? Thanks in advance to anyone who replies
 
^true that.

I forget the name if the antibiotic I was n when I had a staph infection, but it actually seemed to rev my metabolism way up, which made each dose of suboxone seem super potent
 
OnCloud9 said:
Good info to know, do you know if its as easy to get up here in Canada?
Click to expand...

It is available in both the United States and Canada under the brand name "Biaxin". You can even ask your doctor for it - I mean its just an antibiotic he would never think that you are going to use it to potentiate drugs. Like I said, it is for chest infections. Say you got a chest cold or something.

I get it easily whenever I go complain of cough and say "I think I have a chest infection or something".
 
waldo777 said:
How do you use it to potentiate methadone? I'm on 130mg MMT myself and was just about to ask about potentiating methadone. In your experience, when is the best time to take this antibiotic? Also, how was your experience taking WGFJ or tagamet to potentiate methadone? Is it that the antibiotic works better, or that the GFJ and tagamet don't work at all? Thanks in advance to anyone who replies
Click to expand...

I am also on 130 mg/day and I just take 1000 mg of it 60 minutes before I take my methadone (I literally nod out and feel a buzz when I use this antibiotic to potentiate the methadone). This antibiotic is a far, far, far more powerful inhibitor of the CYP3A4 enzyme. So GFJ and cimetidine don't even compare. I never really got much from them, anyways.

And to those saying it isn't good to use antibiotics without a real infection are wrong. You just build a resistence to the drug, but there are always others that will work for the same purpose.
 
So it's not a bad thing to have a habitual antibiotic usage? Or is this like a one to two week thing at most, since I imagine your doc would wonder why you have a year round chest infection that antibiotics do nothing for? Well, unless you made the rounds to urgent care places, but that would be expensive as hell.
 
Lindhorst said:
So it's not a bad thing to have a habitual antibiotic usage? Or is this like a one to two week thing at most, since I imagine your doc would wonder why you have a year round chest infection that antibiotics do nothing for? Well, unless you made the rounds to urgent care places, but that would be expensive as hell.
Click to expand...

Yeah, I mean I don't go for it everytime I finish a script. I'll go every 3-4 months and complain of a chest cold or something.

Here is a paper which lists "strong CYP3A4 inhibitors", "moderate inhibitors" and "weak inhibitors". As you can see, clarithromycin is in the "strong" category, whereas GFJ is in the "moderate" category, and cimetidine is in the "weak" category. Just scroll down to the bottom of page 2.
 
spini4 said:
Only one problem with this is that I believe you should not take antibiotics unless absolutely needed as your body may become immune to the antibiotic over time.
Click to expand...

Also, if you have any type of bacterial infection (which you might not be aware of yet) taking antibiotics can cause the bacteria to mutate making it immune to the antibiotic you mentioned. This can also affect people that you are close to because if you are contagious the strain you pass to them will be resistant to the clarithromycin. This is a major concern of the AMA because then they have to find a new antibiotic strong enough to fight off the mutated strain of bacteria.
 
There are a lot of antibiotics that could cause Severe issues if your on mmt/or taking opiates for pain. I know some actually Lower the amount of drug you get. I would advise noone does this. Antibiotics can Cause infections. This is not safe smart or senseable. If you want to poteniate take more of your doc. If youre on mmt then the last thing you need to worry about is making your methadone dose stronger and going against what mmt is for and why youre there.
 
ihatepipes said:
Also, if you have any type of bacterial infection (which you might not be aware of yet) taking antibiotics can cause the bacteria to mutate making it immune to the antibiotic you mentioned. This can also affect people that you are close to because if you are contagious the strain you pass to them will be resistant to the clarithromycin. This is a major concern of the AMA because then they have to find a new antibiotic strong enough to fight off the mutated strain of bacteria.
Click to expand...

There are plenty of alternatives to clarithromycin, so don't worry about some mutation of some disease that will destroy the world. Relax it's an antibiotic that has many alternatives if you grow resistant to it. I know many people that use this to potentiate benzos and opiates and have so for years. We don't yet have some disease that is going to gobble up the entire earth population.
 
BananasAndOranges said:
You have zero claims to back Any of that up.
Click to expand...
And your claims are backed up ?

On topic; I have found Tangement and grapefruit juice to significantly potentiate opiates but I have never heard of using antibiotics..I'll have to try that.......

unless I'm going to obtain some infectious disease that results in the end of the world
 
Well, I still love my tagamet. From what you've said I am totally motivated to get some gfj, as you say it's supposed to be a more powerful inhibitor than tagamet?

Regardless, tagamet has been working so well for potentiating my suboxone, I have no real desire to experiment more with others, short of gfj (as I really like grapefruits too!).

Instead of calling one another silly immature names, wouldn't it be oh so much more productive to instead say something like, "No, you are incorrect for the following reasons..."
 
I think methadone works fine on its own why potentiate it? Be a grown up and use the clinic like a responsible person instead of someone who just likes to get high and nod off.
 
Status
Not open for further replies.
Top