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Potentiating MDMA with bupropion

Psychonauticunt

Psychonauticunt

Bluelighter
Joined
Jun 1, 2010
Messages
1,493
This study explored the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the transporters through which MDMA releases dopamine and norepinephrine. The pharmacodynamic and pharmacokinetic interactions between bupropion and MDMA were studied in healthy subjects. Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations. The results indicate a role for the transporter-mediated release of norepinephrine in the cardiostimulant effects of MDMA, but do not support a modulatory role for dopamine in the mood effects of MDMA. The results also indicate that the use of MDMA during therapy with bupropion may result in higher plasma concentrations of both MDMA and bupropion, and enhanced mood effects but lower cardiac stimulation.
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Anyone with anecdotal evidence? If it reduces the physical symptoms such as cardiac stimulation and overall norepinephrine release, while leading to higher concentrations of MDMA and enhanced mood effect and duration...
 
I have mentioned bupropion (née ambufemone) seems very dangerous. That the choice of the hydrochloride (and latterly hydrobromide) addition salts were clearly chosen on the basis that they are almost totally insoluble in water and that the pKa means onset is slowed down.

We KNOW that even at prescribable doses, dose-dumping led to seizures.

I also keep on mentioning how in almost every nation, bupropion is carefully 'ring fenced' in it's legal control (almost certainly due to pressure applied by GlaxoSmithKline) which means possession isn't a crime and even dealing the stuff could only ever be legally framed as 'distributing a prescription medication without a licence'. That, the fact it only costs $50-$80/Kg in bulk and the fact that the sulfate salt is freely soluble in water i.e. insuffusion of a large amount very quickly would be practical all conspire to make it a VERY likely drug to be misrepresented as something else.

So my informed HR advice was to tell people to test bupropion with a home test kit so that in future, WHEN it turns up misrepresented as something else, customers can very quickly spot the lie and I HOPE descide it's just too dangerous.

Who knows what snorting 300mg FAST would do to a person? After all, the difference between a LOT of drugs is as night and day when consumed parentherally. I'm not saying it would be in any way pleaurable, but as YOU note, people may mix it and worse - so may retailers.

It's a 'mystery powder game'.

Stay safe!
 
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I suppose I’d need to read the full article but I’m hesitant to agree with the findings. “Subjective effects prolonged” is just that, subjective. Who knows if the effects were superior to or inferior to MDMA alone, and that’s hard to measure unless in proper set and setting.

-GC
 
Potentiation could include mitigating the potential for neurotoxicity (excitotoxicity) by using an anti-glutamatergic, GABAergic or anti-glucocorticoid.

Ideally you'd construct a fully sustainable self-regulating combination which produces the typical MDMA experience. Everything needed is OTC and doesn't involve any amphetamine-type drugs.

Shulgin documented the first MDMA mimic using 2C-B-FLY, cannabis and Rilmenidine (α2-adrenergic, imidazoline agonist). Adding a stimulant would complete the recreation, but it's optional.
 
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