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Potentiate Codeine

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Anon54

Ex-Bluelighter
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SUBSTANCES TO POTENTIATE CODEINE

Grapefruit juice ?

Anithistamines
-Diphenhydramine (Benadryl) 50mg-100mg ?
-Promethazine (Phenergan) 25mg-75mg ?
-Doxylamine Succinate (Restavit) 25-50mg ?

Cough suppressant
-Dextromethorphan (Robitussin DX) 25mg-50mg ?

CYP450 interactions.pdf

From this Information it only lists Diphenhydramine as an inhibitor out of my list but anyways...

I Only want information about the products I've listed (So I don't want mention of "throw in some benzos" or "smoke some weed" because they're just combining the drugs & not potentiating the conversion of Codeine to Morphine)

Question 1, Which of these 3 Antihistamines listed in your opinion is the BEST to help convert more Codeine to Morphine & Do you take it before or after dosing the Codeine?

Question 2, Does DXM actually help convert Codeine to Morphine or is it simply combining the drugs, is it more effective at converting Codeine to morphine than the best anthistamine & Do you take it before or after dosing the Codeine?

Question 3, What's the deal with Grapefruit juice, & Do you take it before or after dosing the Codeine?
 
I prefer promethazine, though it inhibits CYP2D6, the enzyme that metabolizes codeine into morphine. Doxylamine is also a good choice. None of them will convert more codeine into morphine for you, ideally take it just after the codeine or when you feel the codeine start to come on. I personally don't like diphenhydramine, but as they say, Diff'rent Strokes.

Question 2: DXM just helps prevent tolerance rising, if anything I imagine it may inhibit CYP2D6 as well since it is converted by that enzyme into DXO.

Question 3: Well, grapefruit juice is the juice of the grapefruit and it tastes nice as a drink. That's the deal.

Oh, in terms of conversion? Take it before the codeine I say, it will help prevent the morphine being metabolized. I used to think it inhibited CYP2D6 as well, but I haven't been able to find any info to back this up and I can't remember where I got that idea from so I'm probably wrong.

If you want to induce CYP2D6 to get more morphine out of codeine, have a standard drink (e.g. 30ml of vodka or whatever) about 45 minutes before dosing. Alcohol will help induce CYP2D6, St John's Wort may do this as well but I have seen conflicting info on this.
 
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