Possible Drugs of the Future

[fastandbulbous]

^ Not really as it wouldn't have an alpha methyl carbon, so had chance to be dealt with by MAO. 3-phenyl-2-methylpiperidine is a psychostimulant by virtue of being a reuptake inhibitor (it was one of a long list of compounds I came across on my post-grad SAR of anorectic drugs project- it's not much cop as an appetite supressant though!)

 

[hussness]

Is it theoretically possible that a mu agonist could also have actions as a psychostimulant? According to the families of drugs I am currently familiar with, that kind of action would be mind boggling.

The only thing I think might come close to it would be mitragynine. Considering both mitragynine and yohimbine are corynanthynines, I was wondering if the anecdotal sympathomimetic effects of mitragynine might be due the alpha-2-noradrenergic (proposed by someone, somewhere), action of yohimbine.

3-phenyl-N-methyl-pyrrolidine sounds interesting. I amnotsure that it would act at opioid receptors, butit might be an interesting psychostimulant--an analouge of phendimetrazine, methamphetamine and aminorex. Since it is technically an amphetamine, I bet it might release monoamines.

 

[fastandbulbous]

I was wondering if the anecdotal sympathomimetic effects of mitragynine might be due the alpha-2-noradrenergic (proposed by someone, somewhere), action of yohimbine.

Yeah, that was me. As a rule, mu agonists seem to have the aromatic nucleus separated from the amine function by three carbon atoms & other than cocaine, all the common psychostimulants generally have a Ar-C-C-N structure. Suppose it would be possible to get a potent reuptake inhibitor with mu agonism, but don't expect to see one as a medicine as something like that would be only developed as a research tool