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Polygala tenuifolia 20:1

G

gh0stmAn

Bluelighter
Joined
Jul 17, 2013
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I am not sure where to post regarding "nootropic" type supplements so I just figured this would be the best place.

I just got some Polygala Tenuifolia extract powder 4 days ago and I must say 'WOW' this stuff really works good. I read a bunch of rave reviews on reddit so I decided to order some for myself. It is supposed to have anti-depressant type effects, which it does. What is really nice about this stuff is that its effects can be felt acutely after taking even the 1st dose.. It's also supposed to aid in healthy sleep and give you calm energy throughout the day, which it does. It has NMDA effects and some people say it's anti-depressant type effects are similar to ketamine. I also read it is a triple reuptake inhibitor. For me it is literally the 1st and only "mood booster" type nootropic/natural-plant-extract that has actually worked and boosted my mood.

Have any of you guys tried this Polygala Tenuifolia extract stuff yet? We should make this a thread to discuss this new plant extract. Because this stuff is gaining much attention and popularity among nootropic taking people.
 
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it depends where you get it from. i also read reddit reviews of tainted chinese powders that made people sick and as expected, contained quite a few toxins and heavy metals.

but besides this problem, is it a stimulant for you or sedative?
 
Coolwhip said:
What are the constituents, and has there been any assays of them?
Click to expand...


What do you mean by "constituents"? I know politicians have constituents but i am unfamiliar with the way you are using it here.
And there is all kinds of information on it out there if you search on google.. I know there has been some pubmed/etc. research done on it.. It really is an interesting plant extract, even a couple of my friends that that tried it seems to really like it, so i know its not just a placebo effect..
 
asecin said:
it depends where you get it from. i also read reddit reviews of tainted chinese powders that made people sick and as expected, contained quite a few toxins and heavy metals.

but besides this problem, is it a stimulant for you or sedative?
Click to expand...

Those Chinese brand one and all others on ebay/amazon are all crap and yes I have heard from other on reddit that they are no good and not even extracts. The one I get is the only good and safe one (according to everyone in the know) on the market right now, no heavy metals or contaminants in it at all, even comes with a sheet of paper from a 3rd party testing lab showing all the technical stuff. Just google search the title of this thread and you will see it. Reddit has a bunch of thread talking about it.

But yeah it is some interesting stuff. It works great as a mood-booster and anti-depressant. Its like the one of the only natural [non-narcotic] mood-booster that has actually worked for me (and I've done a lot of natural "mood-boosters") and many others according the the internet. All I know is that is messes with NMDA receptors, its a triple uptake inhibitor and also works good for nice calm feeling and motivated energy. It makes you want to get stuff done without being stimulating like stims. Its helps you sleep too but isn't sedating if that makes sense.. There's tons of info online about it. Oh and by the way the dosage is 100mgs 3x's a day.
 
Don't trust "third party" documentation provided by the people selling you the extracts...
 
I've been doing quite a bit of research on this plant. I'm just gonna dump all my info here.

Sedative, anxiolytic, nootropic, adaptogen, antidepressant (pubmed/20645779), anti-psychotic. Promotes neural stem cell differentiation in hippocampus, improves NCAM glucose utilization.

Agonist at: A2A, GABA-A (?)(pubmed/23852644)

Antagonist at: NMDA

Inhibitor of: MAO-A, MAO-B, AChE

Induces: BDNF, NGF

Mixed sources: pubmed/24744810, pubmed/19429065, onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.2011.01281.x/abstract , pubmed/18693285, pubmed/19726361, pubmed/20645780, S0278584614000438, pubmed/20645780, pubmed/24520403, pubmed/18712849, pubmed/15464827

It has a compound named Yuanzhi-1 which is an inhibitor of SERT, DAT and NET (pubmed/25638027, pubmed/24614095)

Another compound called Isocorypalmine is a partial D1 agonist and a D2 antagonist (pubmed/24080315, pubmed/7709740).

I once bought the raw herb at a chinese grocery store and ingested something like 10g of it. The effect I got was weird, because it felt distinctly antidopaminergic and serotonergic at the same time. I ended up sleeping for 14 hours straight, and woke up feeling completely spaced out. This feeling lasted well into the day.
 
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d607ebd4fd.jpg

yuanzhi-1 (check out that 1' alkyl chloride ... on a triterpenoid steroid saponin ? and NINE whole chiral centers too)


isocorpalymine:
6c6fa0c466.png


this looks to me like some of those poppy alkaloids - sanguinarine and the like. I hope it isn't a cell cycle toxin like sanguinarine nor an escharotic (scar-forming compound) because otherwise ... well, when it burns holes stright through your gastric mucosa ....
 
If it does give euphoria and/or energy someone will probably put it in an energy drink since only "herbs" are allowed in supplements (even though they get away with putting some nootropics or light synthetics in)

Too bad we didn't have a WAY to get better synthetics to market that don't have anything to do with medicine or big pharma. Some companies are just doing it. i see phenibut listed as an ingredient in nationwide vitamin stores, for sleep etc.

Forget the name of one, but these guys made some super smart pills and they're just kinda saying FU FDA and selling them for consumption in pills to speed things up.
 
I've been chatting with various companies [snip] one quoted me [something] for 1kg of 10:1 extract of this Polygala tenuifolia stuff. They also have phenylpiracetam [snop]. They specialize in chinese herbs so listed a bunch of other ones I have no idea about. I did get a free sample of cialis from one of them that is top quality. Came in like one day overnighted from china sealed in a foil bag pure white.


[no]
 
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just sekio is anal about it. you can try to source either in PM or on the other available sections of the forum here
 
Why is it a rule even for a fully legal substance? It's like saying where to buy an exotic beer isn't allowed.
 
sekio said:
Don't trust "third party" documentation provided by the people selling you the extracts...
Click to expand...

Well the place I got this from is a very very reputable company. Anyone that knows anything about nootropics and the such know this company doesn't mess around so I fully trust the information that is sent along with the compound stating the heavy metal content and such..

Sekio - are you saying that this stuff may not be safe or something? If so please let me know as I have been taking it on and off sense I first posted this thread. I haven't noticed any bad side effects thus far. And I have given some to two of my friends that are into nootropics and they both said they liked it as well. One of my friends just recently came off low dose mirtazapine when I gave it to him and he said it seemed to help him a lot.

_______________________________________________________________


If you guys want to try the same extract that I have been using of this stuff just google "Polygala Tenuifolia 20:1" and it is the first link that pops up.

Anyways have any of you guys tried this stuff yet? I would like to hear other peoples stories about how this effects them. I know a lot of people say it helps with general anhedonia. I like it because the effects are very acute, you feel it within 10-15mins after taking a 100mg dose.

One person posted this in the reviews of it:
"HOWEVER on that note - I would steer clear of any monoaminergics used in tandem with this, to reduce propensity for psychosis (on dopaminergics), hypertension (noradrenergics), or hospitalizing (serotonergics) symptoms."

So it sounds like it may have some MAOI type effects or something..


By the way 5HToInfinity I have heard the raw herb of this plant is way different then this extract. So it seems like the 20:1 extract has different effects then taking the whole herb..
 
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purchased some of the 20:1, can confirm everyones assessment of effects! I seem much less depressed/anhedonic second day in, kratom taper becoming much easier. This stuff is a keeper!
 
definitely some MAOI activity. I want to know how LONG the pharmacological properties last? I might want to do some cocaine soon and a long lasting triple reuptake inhibitor with MAOI properties sounds like a pretty terrible mix....
 
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