I've been a poly-drug abuser since highschool, started out with alcohol, pot and cigs like most of my peers, and amazingly never took anything else until I broke off university in my mid-twenties. Was close to being an alcoholic then, until I discovered opiates, which completely curbed my desire to drink, even if only taken every few months when I could get them. I still smoked pot like it was going out of style though (hence dropping out of uni.)
I went a bit overboard with other stuff as well (DXM, DPH, MXE), but strangely enough never tried real psychs. After that, the opiates took their real hold on me.
Since then, I had several H habits, some more severe than others, and picked up a diazepam dependence on the way. Currently in WD again and tapering the benzos, I'm at 20mg atm, tried CT but can't afford to be a total wreck for weeks on end. At least with opiates, I can still work thanks to Subutex, Kratom and loperamide (not all at once of course!) and then slowly taper off that.
But it was always the combos that were best, especially with opiates. Never again though, this is the one class of substances I'll never touch again after this is through, I just can't control myself when it comes to H.