For 1 month I used suppositories for my daily weed medication and I had mixed results. The high is more like smoking and not like edibles. It does not flow as smoothly, I was at times so high it was challenging despite actually using less thc. Some days it didn't seem to have any effect despite all my doses being identical.
When using edibles I've learned to be patient and not double dose, occasionally if I've eaten a large meal I may not notice my meds at all, (I think that is the medical goal but I still like a mild high). With the plugs it arrived very quickly (20 minutes) or not at all. Being gassy kinda kills the delivery method so in my final decision I will use edible and save plugging for those days when I don't want weed on my breath. It works but it was less predictable.