• MDMA &
    Empathogenic
    Drugs

    Welcome Guest!
  • MDMA Moderators: Esperighanto

Plugging Questions

Thanks for all of the comments.

So my wife and I plugged over the weekend and we both LOVED it. Best roll for her since our first roll.
 
alasdairm said:
if bioavailability is defined as "the rate and extent to which a drug reaches the systemic circulation"
Click to expand...
Right, time to clear this up.

The definition of bioavailability is: "The fraction of the administered drug that ultimately enters the systemic circulation, with the exception of the hepatic portal vein.

The hepatic portal vein is a large vein that carries blood from the small intestine, where nutrients and most drugs are absorbed, to the liver, where most drugs are metabolised and deactivated. This means that any drug that is taken orally and is not taken up in the stomach but in the small intestine will first pass through the liver. Here a certain fraction of the drug is metabolised before entering the bloodstream, i.e. first-pass metabolism.

Bioavailability is not an absorption rate and has nothing to do with how quickly or for how long a drug is active.
It is simply a measure of how much of the drug that you "take" ends up in your blood, from where it can start doing its job of making you happy.
("Take" = swallow, snort, inject, inhale, insert in various body cavities, drip into your eyes or just place under your tongue)

Having said all that, this lowly newb humbly begs alasdairms forgiveness for correcting an admin. Please don't smite me!

*looks around, surprised to be alive*

OK then. My dear Alasdairm, could you point me to somewhere I can find MDMA bioavailability following different ROAs? Pubmed, web of science, google, wiki and the BL 12-page bioavailability thread have all let me down.
 
dutchfreak said:
Having said all that, this lowly newb humbly begs alasdairms forgiveness for correcting an admin. Please don't smite me
Click to expand...

This is a site for everybody, all the information should be true regardless of who it came from. I'm sure Alas won't mind a bit :)


Welcome to BL!




I'm not sure about the ACTUAL BA% though.. but I do know methamphetamine has a 99% rectal BA, and I'd assume MDMA to be close as well
 
Questions about plugging...

Hi everyone. So I'm really considering plugging molly after doing some research, but I have a few questions... What's the best way to plug? Apparently some people like to use a syringe with molly and water, some people use a gel capsule with molly and some people use molly wrapped in toilet paper. What's the best, easiest and most comfortable way to do it? How much should I take? I'm not a frequent molly user, but I do want to roll hard =D Also does plugging hurt? Any other suggestions would be greatly appreciated!

Thanks!
 
It won't hurt as long as its got some lubrication and you go slow and easy, nice and sensual-like, yeahhh that's right. Also avoid using turkey basters. They may hurt a bit. ;)
Happy Pluggins indeed

Another great thread for you to check out would be - Big & Dandy guide to plugging

I'm going to merge this with the other plugging thread that was brought up in this thread.
 
You must log in or register to reply here.
Top