Please help me convert Oxycodone 5mg dose to an Oxymorphone IR equivilant dose

[Parabunter]

^^ Crashing... right... I get that part, thanks. The part I'm asking deidara to clarify is part that says:

so that's closest to what your 5mgs would do.

is that math supposed to assume something like :

.6mgs x 8 = 4.8 (about 5mgs OxyC) ? or something like that?

 

[Parabunter]

^^ Crashing... right... I get that part, thanks. The part I'm asking deidara to clarify is part that says:

so that's closest to what your 5mgs would do.

is that math supposed to assume something like :

.6mgs x 8 = 4.8 (about 5mgs OxyC) ? or something like that?



BTW, she just had 2 days with only the OxyM, and she reported that it was really a disappointment as a replacement to the OxyC. She said that she might not even compare it equal at a conversion of 4x's !

 

[T. Calderone]

So Parabunter, how much did you sniff and how does it compare? Meaning how many mg oxymorphone do you find equal to oxy?

 

[Crashing]

Not to answer out of place but..

Take 5mg of ocymorphone. The oral BA is 10%. The nasal BA is (we'll call it) 40%.

So 5mg oral x 10% = .5mg in bloodstream

So 5mg nasal x 40% = 2mg in bloodstream.

So to get a nasal dose of oxymorphone, we have to account for the 30% increase in bioavailability.

30% of the original 5mg ingested is 1.5, and 1.5 + .5 = 2mg. That means 2mg snorted will equal 5mg oral or oxymorphone.

Now, oxymorphone is twice as strong as oxycodone.

Oxycodone has a similar nasal BA as oxymorphone, so basically just take your oxymorphone dosage (2mg snorted) and halve it.

That means roughly 1mg oxymorphone snorted equals 5mg oxycodone snorted.

 

[Parabunter]

Great update ! She agrees with that from her relative experience. (She says it feels like it is somewhere between 1 to 1.5ish IHO). ... but that something is still not quite right with it for her anyway. She said at those replacement doses she kept going into a bit of withdrawals, even though it was supposed to be a longer half-life. And she said, that because it takes a while longer to take effect, that the mornings were not so good(she was in pain!) .


So, I think we've solved this, anecdotally as well as mathematically....or at least we are close. She wanted to be sure that the relative experience for her was included in case anyone else needs to know an opinion on it. (such a nice gal ! )

The one concern I might have with the logic above... is ( and this could be wrong, so don't quote me)... but what I've read, said that OxyM is about 2x's as strong as OxyC , administered PO. Then it would say something like, "it's considerably stronger insufflated, and then talks about the difference in bioavailability. BUT.... it doesn't say , "universally, OxyM is always twice as strong. Actually it says that it will vary according to intake method. So, I'm not exactly sure that we can say that it's both 40% vs 10% bioavailability, (thus 4x's stronger)...and then also, go back and say that it's also twice as strong. (and multiply it by 2 again). I'm not sure actually.

So, that's something to consider perhaps ?

....edit: actually wait, I think you were right? Does it say that mg for mg once it's in the bloodstream it's twice as strong?

 

[Parabunter]

abc

 

[Parabunter]

Hey , she wanted me to update and say a few words about her experience in switching between them. Here is a what she said in an email.

"Opana is strange. It seems sort of light and weak many times, and when trying to convert it, it can be tricky, at low doses. However, it stacks up. That's the important part I wanted to say. I was taking it one day, when this Idaho weather was again keeping me inside all day, just like I would the oxycodone 30mg pills , and frustrated with the lack of good feeling / pain relief it was producing. Low and behold, by late in the day, it was clear that I was waaaay past what was typical experience for me. And the thing is ....It was NOT pleasurable. That's the trick with opiates. If you take a bit and don't feel "great" then you might want to take more. the problem is that too much can really be making you feel worse !

I just want to caution about this stuff, so that nobody hurts themselves with it. It really can stack up, due to the long half life. And you can't always determine where you are at by "how good you feel".

Just be cautious. "

 

[tomatalli]

The oral BA% of oxymorphone is 10% (as said above) and the oral BA% of oxycodone varies between 60-87%, we will call it 80%
Orally oxym is twice as strong as oxyc (because of the high Oxyc BA and low oxym BA) so if you take 5mg of Oxyc orally it would equal about 2.5mg of oxym. When you break it down 5mg of oxyc orally you really get 4mg of oxyc and, if you take 5mg of oxym orally you really only get .5mg so mg per mg at 100% ba oxym is 8 times stronger.
When snorted oxyc has a 60% ba and oxym has a 40% ba
So if you ingested 5mg snorted your getting about 3mg, if you snorted 5mg of oxym you really get 2mg. So if your used to getting 3mg from the 5mg you snorted you should dose 1mg of oxym snorted because that equals about .4mg of oxym and 8x.4=3.2 so that's roughly equal.

 

[Parabunter]

***HELP PLEASE(not an emergency or anything , just a confusing situation now with conversion!) ***



Error on the side of caution all the time! If you are new to this
medication then take it as easy ! Do not wack yourself by listening to the opinions here! *
In the end, after this was written she did say that 15-20mg OXyM felt like about 30mg of OXyC
but the good part was that it lasted for several straight hrs....and she said that it seemed
to take quite a bit to establish a 'base'....So, anyway, that's just one opinion, which might
change by tomorrow.





with that said... maybe someone can tell me why it doesn't seem to be working very well.?

The math all looks correct in what's been said here...but listen this:

She just ran out of her oxyC and had only oxyM to use for pain. So, doing the math she dosed at what would be here regular oxyC dose. FOr 2 days she felt horrible. In pain, headache, yet pupils were reacting as if she had a larger amount of the opiate OxyM in her system. To make a long story short, she got fed up and decided, she was in pain and needed to take more. So she took a full 10mg OxyM insufflated. Which is supposed to be a minimum of 4x's stronger right? I mean at the VERY LEAST. (really more like 8x's stronger than OxyC right?)....but she reports that this was NOT THE CASE AT ALL!

**NOTE**nobody should take this as fact and hurt themselves...but she is still in pain after 12.5mg in one hr. time.(inter nasal ). She said it feels like she took about only 10-15mg of oxyC alone!!! ??? Its so puzzling! Does anyone understand this? She 's been so respectful of "the strength" of this drug, Oxymorphone, that she took it very very slow. But now she is sure that those numbers can not be correct! Its either that or the company (TEVA) changed the IR pill so that it is NOT such a strong increase in internasal ROA. ?????? Soemthing's up! IDK what. This crap is not working ! !!! ! !

WIth the oxyC she said it seemd to work well together, like it potentiated each other, and gave the OXyC "legs"....but I am doubting even that now. What the hell is going on? She isn't going to push it, and risk the long half life putting her in danger but simply put.... at 16mg now this drug is not stepping in to do it's job! There is no way that we could say that it is equal to 7-8 , 5mg doses of OxyC. (35-40mg OxyC vs 16mg of OxyM .... it just doesn't seem that strong!)....no doubt about it. Pain does not lie. She is in pain! WTF? So, she is concluding anecdotally that OxyM seems to her to be about the same exact pain relief as OxyC (inter nasal)..again dont take her word for it. She actually just told me that the OxyC might even be more effective than the OxyM at the same dose!? How can that be?

Can someone please help explain before we begin to come up with conspiracy theories of false conversion ratios begin shared online, or manufacturer change in drug formula...or????? The worst part is how much she paid for these because she thought they would last! damn it. I feel so bad for her.