very interesting, so like a compressed nasal bupe spray? the things I don't know could fill the internet haha.
Bioavailability wise I know if you add even 1ml of alcohol *less even* under your tongue before bupe it increases the bioavailability quite a bit. But that has a # of health problems too. Mostly dental. which sub is a monster for anyways.
honestly I think im doing less damage to my nose than I would be my teeth. If you see a tremendous flaw in my logic let me know.
Yeah, compressed nasal spray is a good description. I assume such instructions were given as opposed to simply making regular spray in case person is in a very bad state or it’s a child or there are a lot of patients as it can be administered faster and a bit more efficiently.
As for dental problems and bupe I have no idea about that and thought that might have to do more with poor oral hygiene and such thing but now when you mention it, given how bad it’s for nose and veins (again I might be wrong but I suspect it’s more damaging than most substance even without binders) it isn’t far too fetched to expect it to be bad dentally too, but that should be easily prevented by using it only sublingualy and not bucaly too. Bucal ROA is a bit more efficient than sublingual I think but I wont use it anymore just in case. But holding bupe under tongue shouldn’t damage teeth anymore than snorting.
If you are prone to sinus problems snorting it should be avoided for sure but even if not most people end up with some nose damage given enough time so it’s really important to stop as soon as any problems occur. After that make sure to stop before any problems occur. I for example know I’ll get some problems after just a week or so of snorting bupe few times a day so I make sure to give my nose a break before that. Also make sure to rinse nose either with spray for that or neti pot, that helps no matter what you’re snorting and even if not snorting anything it helps those with sinus problems. I never tried snorting pure bupe nor making a spray with it but I’m sure it would give me some more time before problems with nose occur. As I said next time I do it I’ll make a spray and report back.
Honestly better BA when snorted with bupe isn’t at all such a big plus for me as when I do bupe I usually get it as a gift from my ex and get plenty enough for a few weeks (usually not of daily use) that sparing it isn’t an issue and any longer than that would bring me to a very bad place. But same as she and most people I know who take bupe for whatever reason almost all snort it as it hitting faster and sole act of using it via that ROA makes it somewhat more recreational. First I tried bupe (when I was a teen) I used it only sublingualy but now after trying many opiods, no matter it’s one I least like I snort it about half a time I use it for that short initial surge of will to do stuff (well it’s a bonus beside pain-relief I really sometimes use it for).
Idk if you read thread about how much weed increases plasma concentration of bupe and/or half-life of bupe, forgot what exactly but that seems to really work. How’s that from point of HR it’s hard to say but weed really does potentate it insanely. I find it similar with many opiods in fact, sometimes all that’s needed to come from barely feeling something to noding is a splif. With longer lasting opiods same goes for getting back some high after peak. Exact mechanism of this synergy with weed and how it’s used could push one toward less or more problematic use. Using a much lower dose of opiod but in combo with weed would probably be beneficial for many but simply using your normal dose and getting a lot more high with a help of weed probably isn’t good at all and is likely to lead to stronger psychological addiction (possibly physical too depending on mechanism of synergy/potentation).
never try.ps it we'll be a waste if you snort liquid boot 
it 
