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Pill Absorbtion & Stomach Contents?

Geist89

Geist89

Bluelighter
Joined
Oct 10, 2007
Messages
762
Location
Los Alamitos, CA
I know this is kind of a weird question, but what are optimal conditions (as far as stomach contents goes) for pill absorption? I'm not necessarily talking about potentiation, but is there a general rule of thumb that medication is more readily absorbed with a full or empty stomach, etc.?
 
I always thought taking it on an empty stomach would be the most efficient

the only time I ever take pills with food is if I know they are gonna hurt my stomach (eg tramadol yuck)
 
do not eat at least for a hour or so if you want to get the correct absorbsion, eating as you start to feel the pill or pills working will be fine and won't really affect anything
 
The difference is so nill to the actual recreational effect IMO.

Physical satiation aspect however as well as peak plasma levels are effected by the contents/pH balance of the stomach at the time.
 
Depends on what and how much of whatever it is that you are taking. Empty stomache would be ideal, but certain stronger drugs or higher doses than normal of certain drugs may be better with a light meal beforehand.
 
I agree. Stimulants should def. be complimented with a small breakfast at least of a high fiber/protein cereal.

Avoid acidic foods. Alkalize your stomach with sodium bicarbonate to lower your pH level.

Green foods, ALL green foods have an alkaline pH. Stay away from citrus and such.
 
There are exceptions to the empty stomach. One would be Opana (which, in the pursuit of getting high) shouldn't be taken on an empty stomach, but rather after a meal with a high fat content. It actually has the same increase in effect if taken intranasally or IV.

With amphetamines you want to have a more neutral stomach pH, as a previous poster mentioned. This can be accomplished by taking baking soda (yuk) or Tums about half an hour before taking them. This only works with the oral ROA.

I've found that Soma works best taken around a light meal, such as soup, a small sandwich, some fruit, crackers, or anything like that (not all those together).
 
I have a friend who refuses to eat anything before taking pills (opiates). I find the difference in the high on an empty or full stomach to be negligible. But thats me.
 
And I have a friend who always ate crackers/cookies after taking pills, to "push them down"
No joke, we're at my house; he swallows a bunch of somas or whatever, and asks "you have any pushers?"
Man I miss getting fucked up with that guy, what a wackjob.
 
Eating after taking a pill will help the pill be broken down because it causes your stomach to release more acid. I always eat a little bit after taking an E pill, or when I used to take vicodin. It helps it kick in a little bit faster.

Specifically focusing on crackers/cookies and calling them "pushers" though? Yeah, thats a little weird.
 
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nleksan said:
There are exceptions to the empty stomach. One would be Opana (which, in the pursuit of getting high) shouldn't be taken on an empty stomach, but rather after a meal with a high fat content. It actually has the same increase in effect if taken intranasally or IV.

With amphetamines you want to have a more neutral stomach pH, as a previous poster mentioned. This can be accomplished by taking baking soda (yuk) or Tums about half an hour before taking them. This only works with the oral ROA.

I've found that Soma works best taken around a light meal, such as soup, a small sandwich, some fruit, crackers, or anything like that (not all those together).
Click to expand...

By the way... eating a FULL MEAL especially one high in fat content works for most opiates/opioids... especially Opana(Oxymorphone). It works with other ROA/MOA's not just oral.

Try eating a FULL MEAL then snorting your dose of Opana a few minutes after your meal for the win... it makes the Oxymorphone 7-10 times stronger than Oxycodone. Without the food snorting it is only 4-5 times stronger than Oxycodone.
 
center said:
I agree. Stimulants should def. be complimented with a small breakfast at least of a high fiber/protein cereal.

Avoid acidic foods. Alkalize your stomach with sodium bicarbonate to lower your pH level.

Green foods, ALL green foods have an alkaline pH. Stay away from citrus and such.
Click to expand...

Quick correction, sodium bicarbonate would RAISE the pH level of your stomach.. an acid would lower the pH level. I don't know if I buy into the theory that messing with your stomach's pH can have an effect on drugs. Your stomach is extremely acidic to begin with so taking a base can only do so much. It also depends on the drug. Some drugs need to be broken down before they can become active such as pro-drugs like codeine.
 
Empty stomach, at least four hours after a meal, more if a lot of fat was consumed, before taking pills. This will greatly concentrate alkaloid impact. The difference is astounding. I would go as far as saying that empty stomach is the equivalent of a strong potentiator. If you have a lot of nutrients in the blood stream competing for receptor attachment then the impact of the alkaloids from the pills will be minimized. A good example of this is this rambling post SWIM is typing right now. It makes no sense because SWIM just consumed 50 mgs of hydro and 3.5 soma pills on a very empty stomach and he is toasted. eat some food a couple hours after pill consumption.
 
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nah if you really want your stomach cleared youll need a full 24 to feel the kickass effect of a chewed oxycontin pill on an an empty stomach.

when i had me tonsils out i had some nice itchy nights wif pks by not eating due to the post operative pains i was in
 
I would love it if someone could explain how eating a full meal right before is awesome- I mean that sincerely; I was always under the assumption that taking pills on a full stomach was bad, because the more food in the stomach, the longer the digestive process, hence the longer blood is pulled away from the brain and less off the drug gets there, and more slowly. Also, even though there is more stomach acid, there is less space in stomach, so the pill is more likely to end up not fully digested because it gets lost in the food (a stomach can not expand forever, so eventually you will reach a point where more food = less space for stomach acid. So, the pill is not going to get as much acid digesting it, meaning more of it is likely to pass through undigested.
I don't know, I would love it if someone could explain it to me.
 
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