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Physical effects of a high dose of APAP?

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ScienceWins

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Mar 11, 2009
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So, tonight I'm going to take 9 vicodin 7.5s. (67.5mg of vicodin, 6750 apap). I know this is quite a bit higher than the regular dose of APAP, but seeing as I very rarely take vicodin without a CWE (it isnt an option at the moment) and never drink, I'm pretty sure my liver is up to the challenge, just this once.

I'm just curious if such a high dose of APAP will have any unpleasant physical side effects? Thanks!
 
If that's all I can expect, then awesome. I'd imagine the painkilling properties of the opiates will counteract that, too.
 
nah man don't go over 4,000mgs of APAP in a day... lol im glad I get (well used to get but got kicked out of my pain clinic for fucking failing a drug test for ONLY CANNBIS!! i had no fucking opiates in my system at all!! wtf?!?!) the 7.5/325 norco's.
 
CWE isn't an option at the moment, and 30mg hydro won't do all that much for me. As long as my experience won't be diminished by unpleasant physical effects from too much APAP, a little liver toxicity seems like a low price to pay for 70mg ofs hydro, just this once.
 
I saw a thread on a very simple version of CWE, it's really easy, it takes one minute, are you sure you can't try that either?
 
Alot of misinformation so far in this thread...

Your kidneys will not hurt because it is not your kidneys that handle acetaminophen, its the liver.

Some people say they "get sick" or feel ill when taking large amounts of acetaminophen but this is largely on an individual basis as it is very well tolerated in the digestive tract.

That said, even if you have full-on, complete liver failure you dont have ANY symptoms for 24 hours. No pain, no nausea, etc. By the time you realize something is wrong, its too late to do anything.

Taking 6750mg of acetaminophen at once is an incredibly stupid thing to do. Thats over the total daily max of 4000mg (hepatoxicity has been documented even at this dosage) and WAY over the single, acute dose maximum of 2000mg.

Think about it...is it worth the risk to not use a simple, effective method that takes 10 minutes to greatly reduce the amount of acetaminophen you take in?

edit - I just saw the part where you said a little liver toxicity is worth it for 70mg of hydrocodone... I dont mean to be rude, but are you fucking serious? Get ahold of yourself, that is just awful to say. Apparently "ScienceLoses" would be a more appropriate username for you right now.
 
7 grams of APAP isn't something you should take so lightly at all IMO. How can you not have access to somewhat cold water and a cup? Outside of a filter that could be many different things including the shirt on your back, thats all thats really needed for a simple CWE.

Anyway, bottom-line, fucking stupid to do what your suggesting. But just because its unsafe doesn't mean I'm going to lie, at the end of the day the human body is amazingly resilient and you will probably be fine. But seriously, don't put your body through such an ordeal just to catch a hydro buzz. Simply put, its just not worth it, even if your addict brain is rationalizing in favor of using because you want to get high.

Oh yeah and to your actual question (sorry I got distracted by the stupidity), you may or may not feel some physical discomfort when using large doses of APAP. I would say generally speaking, taking too much APAP isn't usually a cause of too much immediate discomfort, but as always, everyone is different.
 
If you'd like to post the very simple, 1 minute CWE process, I'll definitely check it out. But I don't have coffee filters in the house that I'm staying at at the moment, and they're required for everry CWE that I've seen so far.

Dokomo- I've read about plenty of people taking 7000+ mgs of APAP who have been fine. From what I've learned, doses this high are very rough on the liver, but a healthy person's liver can handle it, provided it is not done often. The fatalities from liver failure after consuming too much APAP are almost always only in the very young, unhealthy, or very old, at least until you get up to insanely high doses.

Sure, I may be putting unnessessary strain on my body, but I've seen no evidence that suggests it will be fatal, at least not for somebody in good physical condition with a healthy liver.
 
ScienceWins said:
If you'd like to post the very simple, 1 minute CWE process, I'll definitely check it out. But I don't have coffee filters in the house that I'm staying at at the moment, and they're required for everry CWE that I've seen so far.
Click to expand...

http://www.bluelight.ru/vb/showthread.php?t=396416 (Mr Blonde’s Basic CWE)

As I said in my previous post, if your wearing a t-shirt right now, you got a filter.
 
Dude...take it from me...I took 10,000 of APAP in vicodin over a slightly more than 24 hour period.

I ended up in ICU for three days with liver levels more than TRIPLE what they should have been.

APAP OD is one of those things that by the time you get any symptoms, there is nothing a doctor can do for you and you die probably one of THE MOST AGONIZING deaths you can.

If I hadn't gone to the hospital to get the antidote, there was a definite probability I could have died.

Why would you risk this for HYDRO of all things? (that's not to say you shoudl do it for Oxy either though).

Please, listen to me. I've been there. Just wait until you can do the CWE. PLease.
 
PillPoppingAnimal said:
haha yeah...

but OP, im in the same situation i take 8vic ESs usually 2-3 times a day, i do do CWE once a day usually with 16~ of them but CWEs suck cuz i feel like i get higher from popping 8 of them than drinking 20 of the CWE
Click to expand...

Theres a method in the megathread I posted thats really high efficiency and explains alot of stuff. It takes longer, but its a really effective and efficient procedure. Plus you could do more than one and just split the water up too
 
dokomo said:
Theres a method in the megathread I posted thats really high efficiency and explains alot of stuff. It takes longer, but its a really effective and efficient procedure. Plus you could do more than one and just split the water up too
Click to expand...

can u send me it


im going to look in ur posts tho but dought ill find it.
 
thats how i do it with a little extra things...

i use warm water in the begining...let it sit til room temp. then put in freezer for 20-35 minutes (usually depending on bowl because some get colder faster) ok but...

does the temp matter THAT much because i just wait for the ice to just start coming up and once it goes away i filter cuz its gotta be over 32F by then, probably atleast 34F...

i use a dress shirt, i cut out a filter and i usually squeeze the solution thru because i found that letting it sit isnt efficient.

i read ur and u say let it sit and once it basically stops to squeez thru, im going to try that.
 
Ok took 7g APAP worth of T3s of all things wen I was 16 and 150lbs. Next couple days felt very lighed headed and foggy. Definstely you won't die but u will have liver toxicity which means damage which means u might have a liver with reduced function for the rest of your life.

APAP is broken down to a very reactive intermediate which will react with your liver cells killing them which is why your liver deactivates the intermediate with glutathione but when your glutathione level runs out cells start dieing and the damage
MAy be irreversuble. should be enough glutathione to convert 2g of apap intermediate at once or 4g within a day. Of course the antidote is N-acetyl cysteinewhich is a glutathione precursor which they give to u in massive doses during Od. Of course if u allready experience liver toxicity then u allready have damage and NAC not guna do much. Since that stupid mistake I've always coadministered apap with nac from the health food store. Watch out nac at high doses required for OD (16g+) just to start off with trends to cause emesis (vomitting) and so redosing would be required which is why it's given iv. Pls either do a cwe or co admin many grams of nac. But pls do not make the same mistakke I did as I have to live with a permanently fucked liver all cuz of a stupid high that wasn't even worth it 8 yes ago.
 
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