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phenylethylamine n-methyl addition

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oxidativeamination

Greenlighter
Joined
Feb 16, 2011
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so the story goes as such, SWIM has done quite a bit of experimentation with oral dosing of PEA hcl with varying but mostly highly charged euphoric, stimulating and tingly results lasting aronud half an hour at doseages around the 2gm mark.
despite shulgin denoting PEA as without central effect i must sorely dissagree.
anyway this has all been said before so ill get on with my point.=D

now as we know PEA is a mono-amine (only one alkyl substitute on the amine group) and mono amines are the ones rapidly metabolized by MAO in the liver.
so if we where to add a methyl, ethyl or butyl group to the nitrogen creating a secondary amine derivative, would this new compound then be spared a horrible and swift demise at the claws of MAO?
any speculation as to added effects in these new compounds?

one could accomplish such a thing by vapourizing their phenylethylamine with some chloromethane/ethane and pyridine to soak the excess HCL no?

any speculation on possible routes of alpha-methylation will also greatly interest me i have searched far and low for this information to absolutely no avail. the info just isnt out there as far as i can discern.

any comments would be much appreciated thankyou bluelighters
oxidativeamination:!
 
It's a known compound but there is little information out there on it's effects.

But this is not a site for synthesis discussion so I am forced to close this, sorry.

You could probably discuss potential pharmacology in Advanced Drug Discussion.
 
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