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Phenibut used for mdxx come down

J

jay12345

Bluelighter
Joined
Feb 27, 2012
Messages
79
Just wondering if anyone has used phenibut while coming down from mdxx or an apb. Thanx
 
My guess is phenibut would be a poor choice for that use (assuming that you're taking it to ease the crash.) It takes around 3 hours for phenibut to even start working, and many people (myself included) get a bit of a stimulant-like effect from it. Also I've heard of all sorts of weird interactions with phenibut & other drugs. It's definitely not like a benzo.

Also, I think a good dose of phenibut makes a great club drug by itself. It's not for everyone though.
 
Neither of these compounds are psychedelics. Since this is MDxx related I am moving it over from PD >> ED.
 
well it would probably help you sleep, you'd have to take it at least an hour before you came down though as it takes a long time to kick in.
 
I have no experience with phenibut, so I can't be of help there.

However, it causes an increase in dopamine and to me that would seem to increase oxidative stress caused by dopaminergic free radicals.. which is not a good thing. You're probably best off sticking with the classic downers.
 
Thank you for the replies. I suffer from anxiety and mdxx just amplifies this during come up, while on, and come down. I enjoy the anti anxiety effects it has but certainly dont want to risk an interaction.
 
Folley said:
However, it causes an increase in dopamine and to me that would seem to increase oxidative stress caused by dopaminergic free radicals.. which is not a good thing. You're probably best off sticking with the classic downers.
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In what sense does Phenibut (or any other GABA-B allosteric modulator) "increase dopamine"? I think that it would do so through such indirect mechanisms as you see with other GABAnergic sedatives (thus making this class of compound reinforcing). Increased dopamine should be so mild and indirect that it doesn't make sense to worry about synergistic neurotoxicity.

ebola
 
Okay. Looking at the article that the wikipedia entry cites, it seems that phenibut might increase intersynaptic dopamine by inducing its endogenous metabolism from ready precursors. This effect is still relatively minor an indirect (particularly given that studies have found limited dopamine reuptake inhibitors to fail to accord serotonin releasers neurotoxocity).

ebola
 
Well I wasn't really suggesting that MDMA and phenibut is going to be harmful like MDMA and meth are.. but since some users report light stimulation from the drug I was just trying to say, there are probably better chemicals out there you can use for this purpose.
 
ebola? said:
Okay. Looking at the article that the wikipedia entry cites, it seems that phenibut might increase intersynaptic dopamine by inducing its endogenous metabolism from ready precursors. This effect is still relatively minor an indirect (particularly given that studies have found limited dopamine reuptake inhibitors to fail to accord serotonin releasers neurotoxocity).

ebola
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^^^^^ SAY WHAT?? Sorry but this is an English speaking only site. Please translate into English for us simple minded folks 8o
 
Close enough, lol. The takeaway is that phenibut causes an increase in dopamine, but it should be minor and gradual enough that this increase in dopamine shouldn't make MDMA's neurotoxicity much worse.

ebola
 
Well i did it and it was a great success. 50 mg 6 hours before dropping 6apb then another 50 1 hour before dropping. Buzz was amazing no anxiety, no edgy come up, and come down very enjoyable. Afterglow tripping FAR more intense then ever experienced. Fell right asleep with plenty of deep and rem sleep. I can't recommend to everyone as i have plenty of experience with phenibut, but my experience yielding better results then i had expected.
 
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