There is the possibility that excess glutamate & low dopamine together with low GABA is responsible for the withdrawal. The (unfortunately currently approved only for Alzheimer's) anti-glutamate and pro-dopamine agent memantine can help very much in many withdrawal syndromes, including GABAergic and opioid. But it seems to be harder to get than it should, as it is a comparatively safe drug.
I looked into memantine before for opioid withdrawal, but also found out it's harder to get prescribed than it should be and I wonder why that is. Back then I was also wondering about it because I was much more into dissociatives at the time and was hoping it might be like DXM in effects. After some searching around the internet the general consensus was that it doesn't act like a dissociative at all, even though it is an NMDA antagonist.
Don't take it too often man.. you will lose the magic completely. I've been off it for months & 2g effects me as such: barely any anxiolytic activity, no disinhibition, no nothing really. Maybe minor mood increase, although i still got the sexual effects (so much so i was able to continue penetration & come a second time.. never happened to me! but my g/f at the time seriously thought i needed sex anonymous b/c i was horny 24/7 & rubbing one out ~3/day). But if id go a tad over? Maybe some music enhancement & some energy.. small increase in libido/sexuality. but even a tad over that (like 3-3.5g; i'm puking for 12 hrs w/ flu like symptoms)
But I suggest if you want to retain your glowing experience you use it sparingly.. i wouldn't even say 2x a week (as most people advise to avoid tolerance/addiction)..i'd say once every 2-4 months.. or for very special occasions when you need it.. holidays, events, special outtings w/ the family or a date (b/c its quite the natural viagra+libido enhancer)
Granted, at my height- i was IM'ing 8g of the stuff (yes took 2.5 rigs..one in each thigh, the remaining in my deltoid)...
Had a huge etizolam habit at the time (425/mg day).. fate (which i don't believe in) intervened & i ingested too much 3-meo-pcp i had laying around, w/ some 5-meo-dalt. Well i was found catatonic & seizuring. Our local shitty hospital said "NO MEDS" on the entrance to my door (not even my subutex). But i was quickly transferred to docs & neurologists who apparently knew their shit over up in Univ of Cleveland hospitals. Put me on my subutex dose; stabilized me on 6mg of lorazepam.. was a week before i started talking..was there for 3 weeks but still don't have any memory of the whole event.
Was only then that it saved me w/ my benzo habit (before kept sending me to psych wards & tapering me in 1-3 weeks regardless of tolerance.. never worked). I tapered off the 6mg of lorazepam in 3.5 months w/o any issues aside from PAWS (much worse w/ benzos than w/ opioids)..in which now i've found myself tapered/weaned off all the ineffective meds they gave me for "depression" (nothing worked, i think i'm in that 30-40% class of AD resistant patients) & on back on a habit of clonazolam since around 9/5.. however, i only take at night 2-3x; & am still functional throughout the day & morning (never any morning doses).. not depressed.. not laying in bed watching TV till 4pm b/c to anxious to leave the house or deal w/ interacting w/ people. Its really been a miracle for me, and my dose has been steady! Finally have confidence back! have several job interviews coming up!
ANYWAY TO YOUR POINT ON PHENIBUT-
When i got out of the hospital (the 3 week stay).. i tried the phenibut again. Nada...zip.. nothing...tried a bit more. 12 hours of flu like symptoms & puking. So don't over do it man. Don't lose that magic..wish i could still reclaim iti still do get those sexual side effects though from 2g, they don't seem to diminish for some reason?
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I'm actually not really looking to retain the magic with phenibut. I think it's already passed to be honest. The first few weeks were great, but when I got my second tub I took PEA while on phenibut a few times right off the bat and since then it seems phenibut makes me hypomanic. I can't distinguish if this is due to me concurrently ingesting the PEA, if it's because the second tub isn't as pure or contains some impurities, if it's because I was taking phenibut daily for some time, if it's because I was taking such high doses (the hypomania also coincided with when I began taking 10g doses), or if it's a combination of some of these. I believe it's attributable to the high doses and maybe the duration of daily dosing.
Another weird thing though is that around the same time I started to lose that increased libido effect, probably due to said hypomania. I still very much enjoy the therapeutic benefits of phenibut though and, as I've said before, I don't mind the hypomania because it makes it very easy to do tedious work and get stuff done. I still get the anxiety relief, extreme confidence, relief from insomnia and yet I also feel stimulated, and elevated mood.
I've never read of someone using the stuff in an intramuscular fashion before, how did the effects and duration of them differ? I'm sorry to hear you had to go through what you went through, but I am glad that you're at where you are now. I currently only work an under the table job that's hit or miss, so I need to follow your lead and line up some job interviews too haha.
It's looking that I'll never get effects from doses as low as 2g ever again. I was doubtful of this anyway since I was only able to get effects from that dose the first and second day I took the stuff. My new tub should be arriving tomorrow so I guess I'll start with 4g, maybe as low as 3. As I said in a previous post above, when I was withdrawing, I took 5g and felt amazing, but this was probably due to me going from feeling like shit to feeling the familiar phenibut effects again.
I was going to quote your next two posts too, but for the sake of not posting a novel here, I'll just reply. I can second the need to stack doses of gabapentin. When the magic was still there for me, I would take 150mg-200mg of the stuff every 30-45 minutes (either half of a 300mg capsule or half of a 400mg capsule). Some hours later I would start feeling great, it wasn't really a high, but it feels like nothing else and I really enjoyed it. The more gabapentin you take at once the lower the oral bioavailability is. I believe this has been posted elsewhere on this site before, but I found it on a drug information site: "Gabapentin bioavailability is not dose proportional; i.e., as dose is increased, bioavailability decreases. Bioavailability of gabapentin is approximately 60%, 47%, 34%, 33%, and 27% following 900, 1200, 2400, 3600, and 4800 mg/day given in 3 divided doses, respectively." So if you take 900mg/day, you get 540mg. If you take 1200mg/day, you get 564mg...it's almost like you're wasting that other 300mg capsule since you only receive 24mg from it. Last week, when I got gabapentin for phenibut withdrawal, they weren't doing much except easing it a little bit. I was taking 4 or 5 capsules a day, so 1200mg to 1500mg. Then the next day, I took naproxen and a good sized glass of grapefruit juice about 45 minutes prior to ingesting the gabapentin and after taking 600mg over the course of a couple or few hours I felt more than twice as good as I did from the larger doses I was taking the days prior. Albeit I did stop taking the gabapentin after that because I got my hands on baclofen and now the withdrawals have since ceased.