phenibut and amphetamin

[logarithm]

Hello,

I take small doses of amphetamine every day and need this medicine to work..So does anyone know if phenibut diminuishes the efficacy of therapeutical doses of amphetamine?

logarithm

 

[Cane2theLeft]

Any sedating medication is going to diminish some of the stimulant effects of amphetamines - to what degree depends on the respective doses and if this will be problematic for you given your needs/uses is impossible for us to say.

 

[logarithm]

I love how phenibut downregulates the peripheral side effects of the amphetamine. But I don't know whats going on with dopamine in the brain? I heard that it's doing something with dopamine neurons. I need to know what happens in long term. It would be absolute horror story, if phenibut results in cross tolerance to amphetamine. Heard its a dopamine agonist... Anyone knows more?

 

[debaser]

Phenibut can be stimulating, as can GHB/GBL, but they're sedatives and phenibut apparently is a dopamine inhibitor. Additionally, I don't see why it would have any cross tolerance with amphetamine.

 

[Quercetin]

Phenibut can be stimulating, as can GHB/GBL, but they're sedatives and phenibut apparently is a dopamine inhibitor. Additionally, I don't see why it would have any cross tolerance with amphetamine.

Dopamine is modulated by glutamate. Gaba and glutamate interact profusely together...

Glutamate and Glycine/Gaba
http://www.acnp.org/g4/GN401000008/Default.htm

Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons.
Amphetamine is a highly addictive psychostimulant that promotes the release of the catecholamines dopamine and norepinephrine. Amphetamine-induced release of dopamine in the midbrain inhibits the activity of dopamine neurons through activation of D2 dopamine autoreceptors. Here we show that amphetamine may also excite dopamine neurons through modulation of glutamate neurotransmission. Amphetamine potently inhibits metabotropic glutamate receptor (mGluR)-mediated IPSPs in dopamine neurons, but has no effect on ionotropic glutamate receptor-mediated EPSCs. Amphetamine desensitizes the mGluR-mediated hyperpolarization through release of dopamine, activation of postsynaptic alpha1 adrenergic receptors, and suppression of InsP3-induced calcium release from internal stores. By selectively suppressing the inhibitory component of glutamate-mediated transmission, amphetamine may promote burst firing of dopamine neurons. Through this mechanism, amphetamine may enhance phasic release of dopamine, which is important in the neural processing of reward.

 

[logarithm]

Thank you for trying to help me. I will take the time and read what you sent me.