Ethnobotanicals Peyote vs Trichs vs Synthetic Mescaline

[MedicinalUser247]

Not trying to derail it at all. Now lets talk more about mescaline. Give me your ideas because I'd like to hear them.

 

[red22]

I also love TMA-2. Very mescaline like and also shares some similarities with DOM, but it leans closer to mesc IMO. That maybe shouldn't be approached here, but I do find it similar.

This is a post I made on YouTube:

Did you know that an alternate name for mescaline is trimethoxyphenethylamine? Did you know that mescaline is similar to alpha-methylphenethylamine (more commonly known as amphetamine)? Did you know that beta-phenethylamine is the body's own version of amphetamine, and that if ingested, it doesn't work without an MAOI? And did you know that mescaline has a poor bioavailability because it is vulnerable to enzymatic attack, and that there is a synthetic analog called trimethoxyamphetamine that has a methyl group that impedes this enzymatic attack, thus giving it better bioavailability? Do you see a connection?

trimethoxyphenethylamine / beta-phenethylamine

trimethoxyamphetamine / amphetamine

The phens have poor bioavailabilities, but the amps have good bioavailabilities. Beta-phen does have a good bioavailability with an MAOI (making it like the speed version of ayahuasca). So, the creation of TMA is similar to the ayahuasca brew (it is a phen with a methyl group, and ayahuasca is basically a tryptamine with an MAOI). TMA can also be compared to psilocybin, while mescaline can be compared to DMT.

And these are relevant posts from another thread:

I think the running theory is that there is MAO in the gut and that it can be "overwhelmed" with enough NN DMT.....some speculate the same is true with oral dosage, albeit an even higher amount is required. The neurosoup girl used 600 mg of the freebase, dissolved in melted butter (so as it aint soluble in water and no one wants non polar solvents up the ass (even butter might be a stretch for some ) and had a hell of a trip. Long ago it was postulated that a similiar mechanism may be at work with mescaline, ie enzymatic or whatever activity in the body that because of the 2 carbon 3,4,5 pattern we encounter in nature our body has a limited ability to break this down, but once we get over around 200 mg of mescaline we are "overwhelmed" and the drug becomes active, which does correspond to the relatively steep does response curve above this amount. *warning* while this "speculation" wasnt conceived over bong hits it may well have been, i remember this idea being tossed around years ago but i dont believe there is anything but anecdotal evidence to support.....but back to the shamanic colonic....

^ That would imply that the dose of mescaline needed by injection would be a hell of a lot less, but as far as I know, the IM dose of mescaline isn't much less than the oral dose.

The 3,4,5-trimethoxy substitution probably allows the mescaline molecule to fit into the active site of MAO, but doesn't allow it to change to active conformation. 2,4,5-THPEA is inactive orally, so it would seem that the 4,5-dimethoxy groups need to have the 3 position free to be metabolized by MAO (3-methoxy-4,5-methylenedioxy is supposedly active at around the 250mg mark, but doesn't produce it's unique effects until 400-500mg). That in comparison to 3,4-methylenedioxyPEA, which is also inactive orally (same thing as the 4,5-dimethoxy groups of 2,4,5-TMPEA).

Other than the 3,4,5-trisubstitution pattern, the 2,4,5-pattern compounds are active if the oxygen on the 4 position (the methoxy group) is replaced by another atom, such as chlorine or carbon (methyl group). The 2C-T-x series exert a significant MAOI activity because of the similarity between the oxygen and sulphur atoms. The S of methylthio group interacts with the active site in the same way oxygen does, but prevents change to the active conformation of the enzyme. Not only does it do this, but it refuses to get out of the active site, so effectively inhibiting the enzyme

This is a summary of the other alkaloids that are present in peyote:

Mescaline itself is the prototypical hallucinogenic phenethylamine. The first chemical study of peyote was published in 1888 by Louis Lewin, who detected a mixture of alkaloids in the cactus that he named anhalonin. Lewin, however, had not demonstrated that anhalonin was the chemical responsible for the visionary effects of the plant. This work was performed in 1897 by Arthur Heffter. Heffter isolated four alkaloids from peyote, one of which he named mezcalin. Unable to distinguish which, if any, of the alkaloids produced the visionary effects by giving the alkaloids to animals, Heffter proceeded with self-experiments. On November 23, 1897, Heffter ascertained conclusively that the effects of mezcalin differed “in only a few respects” from those of the whole cactus, by ingesting 0.15 grams of mescaline hydrochloride.

Edward Anderson lists fifty-seven different alkaloids that are found in peyote. The major alkaloid, and the one responsible for most of the plants noophoric effects is 3,4,5-trimethoxy-phenethylamine, mescaline.

The total alkaloid content is typically three to four percent of the dried buttons, 0.4 percent of fresh heads. Figures for the actual percentage of mescaline vary widely, but seem to center at around 30% of the total alkaloids. This translates to between one and two percent mescaline in dried buttons. (Heffter reported 6.3 percent, but all other workers have found lower values).

Lündstrom, who reported the 30% figure as mescaline's share of the total alkaloids also reported pellotine, 17% of the alkaloids; anhalonidine, 14% of the alkaloids; hordenine, 8%; lophophorine, 5%; 3-hydroxy-4,5-dimethoxy-PEA, 1-5% of total alkaloids.

To put one persistent myth to rest, there is no strychnine in peyote. The white fuzz that is usually removed from the buttons before ingestion can be a gastroirritant, but it does not contain strychnine. However, lophophorine, accounting for about 0.18% of the dry weight of the buttons, can cause some symptoms similar to strychnine poisoning, such as a sickening feeling in the back of the head, and hotness and blushing of the face. Lophophorine causes violent convulsions when injected into rabbits at concentrations of 12 milligrams per kilogram of body weight.

Pellotine, the most prevalent alkaloid in peyote after mescaline, also can cause convulsions—at least in frogs. In humans, pellotine is a hypnotic: slowing the heartbeat, decreasing blood pressure, an eliciting drowsiness and a disinclination for physical or mental effort. The effects of anhalonidine are similar. In frogs, large doses lead to complete paralysis.

Anhalonidine, pellotine, lophophorine, anhalonine, anhalinine, anhalamine, and a dozen related tetrahydro-isoquinolines have two rings. A methyl group on the nitrogen bends around and connects with the phenyl ring. Some of them have a 4,5-methylenedioxy ringlet. The profound Dr. A. Shulgin, in PIHKAL, has predicted and named (and synthesized), an undiscovered biosynthetic precursor for these molecules: lophophine, 3-methoxy-4,5-methylenedioxyphenethylamine. He believes that it should be active, though his own tests failed to reveal any activity in doses up to 250 milligrams. Nor has the compound been found yet in peyote. Dr. Shulgin believes that both negative data will change in the future.

Hordenine (4-hydroxy-N,N-dimethyl), present in peyote and in many other genera of the cactaceae, is also widely distributed in the grasses. Hordenine has an effect on the heart muscle similar to ephedrine, and causes hypertension and accelerated pulse. Large doses are lethal, paralyzing the respiration. Hordenine is a powerful topical antiseptic, and is probably responsible for at least some ofthe demonstrated antimicrobial virtues of peyote juice.

Pharmako/Gnosis: Plant Teachers and the Poison Path. Dale Pendell, 2005, 2009. Peyote: Lophophora williamsii, pages 105-107