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  • BDD Moderators: Keif’ Richards

Percocet, Valium and Effexor XR

BabyGurl3171

BabyGurl3171

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May 25, 2010
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In my mind. The choices are many, the consequences
Due to a really messed up ankle, my dr had me on Perc 10's. I usually take 7 of those with 15-30 mgs of Valium and 50-100 mg of Benadryl (I have a high tolerance to meds) and the combo gives me a decent high. However, he has now changed me to Perc 5's. So, I have two questions...do I just take 14 Perc 5's to make up for the lower dose now? And I have heard and read Effexor can make the opiate less effective, is this true and how much does it block it? Thanks so much for your help! Oh, I'm on 300 mgs of Effexor XR if that matters.
 
14 Perc 5's is 4500 mg of tylenol. The recommended maximum daily dose is 3500 mg, I really wouldn't take that much. I don't know if Effexor would make opiates less effective unless it acted as an opiod antagonist? Don't know for sure but it's hard to see why it would
 
About the tylenol issue, as other people have mentioned those dosages could be really bad for your liver so you might want to read through the Cold Water Extraction Mega Thread to remove the tylenol from your pills!

I don'r know for sure about the effexor but I read on drug interaction checker that taking both could cause serotonin syndrome which might be something to think about.
 
Haha we've had a lot of threads that have involved discussions like this.. technically venlafaxine (effexor) can affect the metabolism of some opioids and could reduce the effects. Difficult to know if it is significant and how much by. The chart I have (here) isn't complete enough to tell me if venlafaxine affects oxycodone but there is another thread about it on here, will have a look in a sec.

The risks of serotonin syndrome with venlafaxine and oxycodone are slim to none, oxycodone isn't significantly serotonergic :)
 
In my recent readings, many people were comparing Tramadol's (pain med I'm Rx'd) sub-profile as an SNRI, to that of Effexor. As effie said, you're not going to run into an issue with the opiates themselves.

Also, I haven't noticed a reduction in effect after taking opiates while on Tramadol - they do just what they're supposed to.

As mentioned - the APAP is the true danger here.
 
^ indeed. Get on the CWE, APAP poisoning is no joke..
 
Jay, Oxycodone is Percocet and my bottle says Percocet so no I didn't mean what I didn't say.
Anyway, thank you guys for your input and help! I knew about CWE and use to do it everytime, why it has been slipping my mind I do not know. I should know better as I've had a brush of hell before...pancreatitis. My liver enzymes hit 46,000! And I went to the ICU. Not good times!
Anyway, about an hour or a little more ago, I took 7 Perc 5's, 200 mg of Benadryl (yeah I'll agree this was overkill), 15 mg of Valium and 10 mg of Ambien. I feel pretty damn good. Nice, relaxing high but not so much I'm panicky or nodding hard. It seems I'm gonna have to always add a lot to the Percs for me to get that happy, warm feeling. Boy, if only it was possible to obtain that first high again! And this is with me quitting in Nov '09 and just starting back on opiates last month. I guess your tolerance never disappears.
Sorry to ramble, but again thank you all :)

*Edit* It was Nov 2010 when I got clean, not '09. And btw, I got killer cotton mouth. Blah!
 
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Even eating 3.5g of paracetamol in one go is terrible. I would recommend CWE'ing even that dose, maybe add in an extra pill if you're worried about losing opioid content (assuming good filtration and proper COLD water).

Jay was making the assumption that they weren't Percocet due to your taking large amounts of them w/o mention of CWE (due to the APAP).

Percocet is Oxycodone and APAP in combination. Oxycodone is its own drug, the former is an available preparation (of oxycodone). :)
 
Well hell lol. I assume this Oxycodone is available in the states? I wonder, when all my drs are always tellin me to try n avoid acetemetaphin (sp), why they keep givin me Percocets instead of Oxycodone by itself. That would make more sense and make it a hell of a lot easier for me to dose. Maybe I'll get the nerve up to ask him at my appt Monday. Thanks!
 
Ahh sorry for my mistake - I was calling Percocet a combination of oxycodone and APAP where it's actually a combination of hydrocodone and APAP. Some time soon they are actually making a hydrocodone-only medication (Zyhydro I believe? saw that somewhere), that I very likely will be attempting to try as well. Alternatively, I believe preparations are available of: hydrocodone / ibuprofin and hydrocodone / naproxen if either of those would be more appealing to you. Ibuprofin actually works for my swelling-related pain (better than APAP or naproxen), so I'm likely going to try for that until the non-NSAID containing ones are released.
 
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