Peptides (CJC, MGF, Frag-HGH, etc)

Now I'm started mod GRF 1-29/Ipamorelin
start from 50/50mcg then increase up to 200mcg each 4hrs(if have possibility) or 3-4 times ED
Shit! 200mcg is blow me- the blood pressure/hyperemia/weakness/drowse
So I get back to 100/100mcg
Now I'm use such stack around week. First what I feel was pumping - really as I remember I didnt feel such pump on roids circle.
Still cant advise regarding fatloss or muscle increasing due to short time of using. Will keep you informed.
Also start MT2 for check how does it works. I plan to take 10mg(1 vial) for around 14days.
 
Well I'd go with regular if you can get it. But something is probably better than nothing if you get my drift, as long as it is a legit product.

Just make sure you read up on hypoglycemia risks before you start using.
 
How long can I run the CJC-1295 + GHRP-6 combo before seeing diminishing returns? I've been on 150mcg CJC and 200mcg GHRP 2x a day for 2 weeks and the results have been a lot more dramatic than I expected. I'm also using IGF-1 2-3x a week.
 
p-mo said:
Anyone on the board used any of the newer peptides?

I'm particularly interested in anyone with experience with CJC-1295, PEG-MGF or the HGH-176-191-Fragment.

These things just look toooo interesting =D
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CJC-1293 with Ipamorelin is the best combo. Ones a growth hormone releasing hormone and ones a growth hormone releasing peptide. One to initiate the pulse and one to widen it. perfect!
 
It is not a good compound. The 1295 peptide itself has good potency, but when you inject it and it conjugates itself to albumin the potency drops drastically. There is a conjuchem publication showing somewhere around a 10-100X decrease in potency for the albumin-conjugate in some assay, I haven't looked at it in a while.

With this effect you have to inject a much larger dose just to stimulate GH release. The doses for CJC-1293 are in the 50-150 ug range versus 1295 in the few mg range.

But that's not the biggest problem. The conjugation to albumin also vastly prolongs the peptide half-life from tens of minutes to days which for a GHRH peptide can be quite problematic. Your pituitary can only release so much GH healthily.

When you have CJC-1295 circulating in the bloodstream it will be constantly stimulating the pituitary to release GH, thus eventually you will deplete all reserves (probably only takes a few days at maximum) and this is not desirable for a protein as important as GH is to our general health (it does a lot). There is some work on "GH bleed" as it is called if you want to search around. Basically it is the "too much of a good thing" type argument. The body is simply not meant to deal with constant stimulation of GH release.
 
that's strange, i certainly have not read other peoples experiences of cjc-1295 dosages in the 1mg to 3mg range.(few mg??) most often it is noted as ~200mcg once or twice a day. and as you state, it does lose some potency and hangs around but in most cases in lower concentrations. i also have read conflicting infos on how many days it remains at the same concentrations adversely affecting 'bleed' it is interesting just how much conflicting info there is on this stuff.
 
Here I put a paper abstract at the bottom where doses of 60 ug/kg and 90 ug/kg were used with CJC-1295. For a 75 kg person (165 lbs) you would give 4.5 mg at 60 ug/kg. You have to get the peptide concentration up to a higher critical point to see any effect in vivo because the albumin conjugation event lowers receptor potency.

You can see this effect in the original conjuchem paper, available here: http://endo.endojournals.org/cgi/reprint/146/7/3052 for free. Look at figure 2 where they test native GHRH versus their albumin-conjugated peptides. Notice how the native GHRH induces GH secretion at lower concentrations whereas the conjugates only do at higher concentrations. Really this data is pretty poor, you can't tell how much lower the potency is exactly because they don't have enough data points or a proper data plot. Is it ten-fold, one hundred-fold... somewhere around there.

Regarding how long it circulates and remains effective. This is a debatable issue indeed, complicated by metabolism. The first thing is to realize that when you conjugate to albumin the ability of the GHRH receptor to internalize its ligand when the receptor is activated (as happens normally with the natural GHRH in your body) and then have the cell degrade the ligand is going to be hurt because you have made the peptide effectively 100X larger (albumin is huge compared to GHRH!). To what extent it prevents internalization we really don't know but it has to be part of the equation or else you wouldn't see such a prolonged half-life with extended time of action. This is a big area of question for these new peptide drugs conjugated to large proteins; how effectively they can be internalized by a receptor. The answers seems to be very little but no one has shown it really. Over the course of days what you are mostly fighting against is kidney filtration and synthesis of new albumin in the body to replace the older albumin. This is probably a fairly person-dependent issue, complicated by metabolic rates and lifestyle habits. But you're looking at <1 week in general no matter how large the dose.

But the free peptide without that "DAC" modification, "mod GRF" as it is being called a lot is actually a pretty good GHRH analog. About the only problem it has is poor water solubility. Outside that its time of action in the bloodstream (before it starts to get degraded) of around 15-30 minutes is just about perfect to give it enough time to make it to the pituitary unscathed where its full receptor potency (another good thing) can be unleashed on those GHRH receptors without beating them to death over an entire day (unless you are one of these whack job bodybuilders hell-bent on taking it 3X a day for weeks on end ;P ).

On a side note, I think I was calling the "mod GRF" peptide the wrong thing (CJC-1293). If you look at the original paper by conjuchem you will see 1293 still has the DAC linker just one amino acid difference from 1295 (Met27). I had thought 1293 was the version without the DAC forever hah. Well anyways it ("mod GRF") is still a good peptide, hence why a lot of people are buying it.

J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7.
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.

Ionescu M, Frohman LA.

Section of Endocrinology, Metabolism, and Diabetes, University of Illinois at Chicago, 1747 West Roosevelt Road, Room 517, Chicago, Illinois 60608, USA.
Abstract

CONTEXT: Pulsatile GH secretion is considered important for many of the hormone's physiological effects. Short-term GHRH infusions enhance GH pulsatility and increase IGF-I, but the short GHRH half-life limits its therapeutic use. A synthetic GHRH analog (CJC-1295) that binds permanently to endogenous albumin after injection (half-life = 8 d) stimulates GH and IGF-I secretion in several animal species and in normal human subjects and enhances growth in rats.

OBJECTIVE: Our objective was to assess GH pulsatility after a single injection of CJC-1295 and determine which GH secretion parameters correlated to the increase in IGF-I production.

METHODS: GH pulsatility was assessed by 20-min blood sampling during an overnight 12-h period in healthy 20- to 40-yr-old men before and 1 wk after injection of either 60 or 90 microg/kg CJC-1295.

RESULTS: GH secretion was increased after CJC-1295 administration with preserved pulsatility. The frequency and magnitude of GH secretory pulses were unaltered. However, basal (trough) GH levels were markedly increased (7.5-fold; P < 0.0001) and contributed to an overall increase in GH secretion (mean GH levels, 46%; P < 0.01) and IGF-I levels (45%; P < 0.001). No significant differences were observed between the responses to the two drug doses. The IGF-I increases did not correlate with any parameters of GH secretion.

CONCLUSIONS: CJC-1295 increased trough and mean GH secretion and IGF-I production with preserved GH pulsatility. The marked enhancement of trough GH levels by continuous GHRH stimulation implicates the importance of this effect on increasing IGF-I. Long-acting GHRH preparations may have clinical utility in patients with intact pituitary GH secretory capability.
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you seem to be stating that any dose below ~60mcg/kg is useless, kinda based on one study using that dose, am i reading you right? cause if that is the case a whole lot of folks reportedly using the substance well under that dose and are reporting positive personal experiences are just deluded. that would be fascinating. mass placebo effect.
 
You need to make sure to you are separating the people using mod GRF from CJC-1295, which are different peptides. Are you sure you have the two straight?

Mod GRF (aka CJC-1295 without the DAC chemical group that lets it bind albumin) can be used at doses of 50-150 ug, it just doesn't last nearly as long in the body as CJC-1295 (which is a good thing).

CJC-1295 needs to be in the 1+ mg range to stimulate GH release, as exemplified by the study I posted.
 
PsychedelicPeptide said:
But the free peptide without that "DAC" modification, "mod GRF" as it is being called a lot is actually a pretty good GHRH analog. About the only problem it has is poor water solubility. Outside that its time of action in the bloodstream (before it starts to get degraded) of around 15-30 minutes is just about perfect to give it enough time to make it to the pituitary unscathed where its full receptor potency (another good thing) can be unleashed on those GHRH receptors without beating them to death over an entire day (unless you are one of these whack job bodybuilders hell-bent on taking it 3X a day for weeks on end ;P ).

On a side note, I think I was calling the "mod GRF" peptide the wrong thing (CJC-1293). If you look at the original paper by conjuchem you will see 1293 still has the DAC linker just one amino acid difference from 1295 (Met27). I had thought 1293 was the version without the DAC forever hah. Well anyways it ("mod GRF") is still a good peptide, hence why a lot of people are buying it.
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I knew I was a whack job, just didn't know using this peptide in this frequency and this dosage made me one lol

I've been SC injecting cjc-1295 w/o DAC and GHRP-2 for the past 4 months or so pretty much 3x/day @ doses of 100mcg or more. I have over the past month skipped several days and also have done a lot of 1 and 2x/day injections over the past month as well.

One day several months ago I IM'ed 2mg of the cjc and 10mg of the ghrp-2 in 5 minutes. I injected about 10 shots in each bicep. The next day I got severe vertigo which lasted a month, no idea if it was related to the injections, doc said I had an ear infection.

Anyway, what I have noticed as far as effects go is increased fat burning capability as I have been eating a lot of cake and other items that have no place in a clean diet. Prior to using these peptides, when I ate any cake or other bad foods my body would put on fat weight on almost a meal for meal basis. This has completely changed. I'm in my 40's and am taking these peptides for this effect and not for muscle mass building.

When I do 5-6 doses a day or more it makes me sleep all night and all day the next day as well. It's great sleep but lasts too long. It is a good way to catch up on some quality sleep though if I had a couple of bad nights of sleep. I get real vivid dreams like I do when I take other substances that also induce quality sleep (ghb, ambien, largish doses of melatonin).
 
Yea that's probably overdoing it quite a bit. Personally unless you are really trying to push the physical limit for whatever inane reason, I don't suggest using it more than once per day, 200 ug maximum dose at night. It would probably be good to take days off as much as you can too instead of every day.

Your body can only release so much GH then it is pointless to take more releasers and will only hurt you in the long run.

There is a limit with this stuff... the ear infection thing sounds bogus. Did you tell the doc what you injected? Haha something tells me you didn't.

2 mg CJC.... this is way too much, be careful.
 
ok, gotcha. the confusion was in the terminology. i'm always looking for cjc-1295 or cjc-1295 DAC. so seeing cjc-1295 DAC as cjc-1295 thru me a bit.
thanks for the overall enlightenment.
 
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