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Misc Peoples experiences with Quetiapine (Seroquel)

Well in my experience it has very strange effects with zero tolerance. Almost felt like I was coming up on a psychedelic or something. I remember feeling trip vibes, and I felt disconnected from reality. Really strange stuff... I should have known right then and there that it was dangerous, but I was desperate at the time and it was the only option I could see.

With repeated use that went away and it made me relatively normal for a couple of months, it was more of a knockout or drowsy type of disconnected feeling, I basically felt like I was being sedated or tranquillized like an animal - that's what they call "getting used to it" - like my doctor wanted me to STFU and just pointlessly exist and wait out an imaginary recovery period when I was actually getting worse from the seroquel - until it became ineffectual and I transformed into a pill popping, pharmacy hopping burnout experiencing extreme terror and panic attacks and calming myself down with booze until I got some better drugs, went through a brief withdrawal involving the wildest dreams I have ever had (way too powerful and uncomfortable), and got a grip on myself. Never again. It sends shivers down my spine thinking back to those dark, miserable times.
 
Rybee said:
Tried it after exhausting a range of Benzodiazepines, Z-Drugs, and other stuff like Tricyclics for sleep... first night I took it, 25mg knocked me the fuck out.

Makes me feel awful the next day but if I really do need to get sleep 50mg will have my lights out in an hour or so. I personally don't see any recreational value in it. Without a doubt the best sleeping medication I've ever tried. Makes Benzo's look like kids sweets in comparison.
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Same here. I got the weird next-day drowsiness from Trazadone but was generally fairly comfortable on Seroquel. Stopped taking it after awhile because my sleeping got better and I didn't want to continue with an anti-psychotic.

But when even 30mg Temazepam wouldn't put me to sleep (was overprescribed benzos at the time), 50mg Seroquel did the trick.
 
Cliffy78 said:
Did that shit really get you high?? Like what kinda high was it? Or was it a "fuck it I'm in the can" type high? Like would you take it to get high now that your home?
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Don't get any ideas, anti-psychotics aren't recreational as much as individuals in this thread may tell you.
 
Nurseebol said:
We give this to elderly and it made u feel this bad? I will keep reading because I don't want my old peeps suffering. We give it to them for dementia related agitation. I no longer work geriatrics, but we use these drugs in hospice as well. Also these drugs are associated with cardiac events in elderly iirc. IMO Depakote works well for that. Never took it myself. Perhaps a new policy should be never to recommend something I haven't tried. One lady we sent to Geri psych was prescribed ambien - during the early evening not bedtime to combat sundowners. It made her a new woman.
All those on high dose seroquel do get that zombie look and pinned pupils. Did it pin your pupils, those who took it?
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Seroquel is supposed to be used with caution in elderly and/or dementia patients.

The largest dose of Seroquel I've been on is 500 mg per day (along with 1500 mg of valproic acid). It didn't pin my pupils (although my eyes would look glassy at times). I found that I'd feel "zombied" for a while following increases in dose but that passes. Perhaps Seroquel was potentiating other drugs your clients were taking.

It's one of those drugs where the appropriate dose is dependent on what it's being prescribed for. At lower (less than 100 mg) doses, it works as an antihistamine which is why low doses are sedating. Whether a given dose is "high" depends on what it's being prescribed to treat. There's not really a compelling reason in geriatrics/palliative care to with-hold benzos, so relying on the sedating effect of low dose anti-psychotics is a bit silly given their risk profile. I have seen Seroquel used in palliative care to counteract the effects of ketamine, which is more in line with the kind of "agitation" they're effective in treating.

Seroquel's popular here with people doing weekend detention who want to sleep the time away and with people who want to end upper binges, but it's not a huge black market in the same way that painkillers or benzos are because they're not an especially recreational drug.

And yeah, off-label use of anti-psychotics is becoming an increasing problem. In my opinion, anti-psychotics shouldn't be able to be prescribed in high doses without specialist assessment. Too many GPs already over-prescribe anti-depressants and they're no adding anti-psychotics to the mix without the specialist training necessary to properly monitor their patients. Anyone who's on anti-psychotics long term should be reassessed on a regular basis and a lot of GPs are just "setting and forgetting", which is irresponsible given the nasty risk profile of these drugs (no-one who doesn't need them should be subjected to those risks).

For people like me, Seroquel is literally a life saving medication and the benefits outweigh the risks, but I sure as shit wouldn't recommend anyone taking it who doesn't have a major mental health disorder. The vibrant/lucid dreams thing is common with the atypical anti-psychotics. Some people enjoy it but I found it kind of exhausting after a while. It was like Seroquel helped my brain be quiet during the day but then it was super active while I was asleep and I went through a period of not feeling rested even though I was sleeping 10 hours a night.
 
I take 125mg of this stuff every night. seroquel gives me an opiate like buzz / euphoria going and i start nodding off, but i HATE the body feeling it gives you, it immobilizes me. and yeah it does kind of zombify you sadly.
 
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If you are going to ignore all the "not worth it" advice, then at least avoid using the XR version. It has a higher risk profile for really nasty side effects and even though I've had no real problems taking normal Seroquel at 500 mg, I've had nasty (and scary as shit) experiences on 150 mg of XR.

The "immobilising" effect mentioned above is very real. I've had it happen on XR and despite the fact that I should probably have called an ambulance and gone to hospital I was physically incapable of doing so. When something goes wrong with Seroquel, your ability to do something about it can be overcome by the effects of the Seroquel itself.

You probably already know your own onset time (I feel hungry about an hour after taking it but I don't feel sleepy enough to go to bed until about 90 minutes after taking Seroquel), but keep that in mind if you're using it recreationally as well so that you're not redosing because you think you haven't taken "enough".
 
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Seroquel is just sad, in my experience although we all have different brains. Whoever said they were snorting it in prison... MAN, prison truly sounds like hell to me!

I hadn't taken quetiapine in 3 months; yesterday I took four 25mg IR over the day because I'm trying to cut back on the benzos. After the experiment I will be happily sticking to my benzos.

Over 24 hours later, I still feel a little retarded from the seroquel. I feel like that drug infected my brain and turned it to mush. Yesterday, although I wasn't anxious it turned me into a zombie. I could barely keep my eyes open at first from the sedation, in the middle of the day when I should be full of energy. But the worst part of it was not the sedation - my brain still doesn't feel right. It feels like a pile of mush that isn't functioning anywhere near its full capacity. It's taking forever for the filth to leave my system... and to think they offer XR!

I seriously regret putting my brain through that, but lesson learned.No more seroquel for me, no more at all... to cut the benzos back a bit I will choose to be extremely anxious more of the time and get less sleep. I'd rather be panicky and crippled with anxiety than feel that brain-turned-mush feeling ever again. It really is a terribly nasty feeling.
 
I've been off it for about 3 months, I was prescribed 800mg twice a day in jail for bipolar. I guess I really do have manic tendencies, as it only put me to sleep for about 6 hours a night, then my morning dose would barely sedate me. I do feel like it helped, but maybe it was because I was using any drugs when I was on it. I eventually quit taking it, just because I feel like it's effectiveness in treating my bipolar wore off, and only left me with sedation.
 
Idk , I have been prescribed it for two years . I love it . When I was diagnosed bipolar and hospitalized for a week . I was depressed for for months , then with great research during my stay , the doc diagnosed bipolar . He prescribed me seriquil , gabapentin, and lamectral . He did it in a careful gradual process . I have made him aware that I had also had sleep problems for YEARS . When prescribed I immediately followed instructions for useage . Nighttime because the side effects were drowsiness. It helped sooo much with my lack of sleep . Which in turn made me have more productive days . That combination of drugs have changed my life forever for the better . I had thought for all my years I had only anxiety, and depression problems . But finally having a doc figure out it was bipolar all those years was an " ah ha" moment for me . So in conclusion , 1. If you get the proper diagnosis
2. With the right prescribed meds . 3. Following EXACT dosage instructions.
4. Also no drinking or other drugs legal or non legal . It could possibly change your life forever .
I now have my bipolar under control . No it doesn't cure it but now I have my episodes of depression , to hypomania way less often . And I have learned the signs and triggers that are coming on and what to expect . I hope tho helps anyone going through some of the same issues . The only side effects I have with the seriquil is very drowsiness and slight trouble swallowing .
 
well I take seroquel daily 100 mg in morning 200mg at night, and I don't feel any sedating effects at all, it has done wonders for me but, for sleep just nah, I take also 10mg zolpidem(ambien) every night and for the last month I have a very high tolerance to both of them.
Even I can say for sure that seroquel caused me insomnia, and yes you can search that some people experience insomnia from it.
I have read somewhere on erowid that quetiapine was used in prison as an alternative to heroin. But I thought it was ridiculous.
I have tried to take it recreationaly too but I had done a terrible mistake, I insufflated 200 mg of it and swallowed 300 It was horrible, I was in real agony I could not sleep and my head was exploding I felt like my brain is trying to escape what I did to him.
I had that terrible feeling the whole next day.
 
50 mg was enough to trigger constant dysphoria, akathisia, drowsiness w/ paradoxical insomnia, nasal congestion, dry mouth and constant hunger.

I have no clue why there is a segment of the populace that takes that crap "recreationally."
 
C6541 said:
50 mg was enough to trigger constant dysphoria, akathisia, drowsiness w/ paradoxical insomnia, nasal congestion, dry mouth and constant hunger.

I have no clue why there is a segment of the populace that takes that crap "recreationally."
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That is exactly what happened to me when I misused it, it was horrible.

But when I take it as prescribed by my doc, I have no side effects at all and it has done wonders for my health problems.
 
I just react terribly to antipsychotics (chlorpromazine to quitapine all make me feel awful) and had to find alternative medications.
 
I was on 900mg IR Seroquel for about 8yrs or so and it done nothing more than make me tired as in pass out tired and gave me the munchies. They also had me on 50mg XR twice a day on top of the IR for a few months. I hated the shit and decided to come off it myself this year, Dr approved and although I now can't sleep for shit my life is a lot better than what it was on the shit :) Just my experience though.
 
Dont try to use those SSRI or ssi's or antipsychotic meds to try and get high, you wont get high and you will damage your brain for life DO NOT DO IT.

anyways i dont use those types of drugs i dont like them.
 
Same , I know different people react to certain drugs in many ways . With any drugs . This one worked best for me . I have never been on any drugs prescribed or otherwise so when the doc diagnosed me with bipolar he was happy to start my meds with a clean slate . There have been a couple days throughout the two years and I did have EXTREME tiredness . Where I literally couldn't get up because of dizziness . But that was because of accidentally taking double dose . That messed me up beyond belief. But yeah in normal circumstance , taken correctly , its done wonders for me on all levels ��
 
I took 600mg/nocte for around four or five years and it saved my life. Sure, it made me fat and sleepy, but I didn't have the symptoms I had before I was medicated, and that was incredibly worth it.

I've since moved on to something less sedating (and, curiously, more effective for the anxiety chunk of my "stuff") but I still really object to the scare tactics around Seroquel. If you're really sick, it's worth the side effects.

I never found that it had any recreational use at all - it just made me fall asleep and stay that way for a long time. A housemate once took my dose of it by accident and said he hallucinated, but it apparently wasn't a very pleasant experience. He didn't wake up for around 24 hours.
 
How safe is seroquel when you take it as a sleeping pill? Could you take it daily?
And how many mgs would you need to become sleepy?

I asked my doc for a sleeping pill and he suggested pipamperone which is a totally old antipsychotic. It sounded way too risky to me.
It can even cause tardive dyskinesia. Taking something like this for sleep seems not worth the risk.
 
glab said:
How safe is seroquel when you take it as a sleeping pill? Could you take it daily?
And how many mgs would you need to become sleepy?

I asked my doc for a sleeping pill and he suggested pipamperone which is a totally old antipsychotic. It sounded way too risky to me.
It can even cause tardive dyskinesia. Taking something like this for sleep seems not worth the risk.
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It's a very safe antipsychotic, comparatively, but things can go wrong with any medication.

I've known of people using 50mg as a sleeping dose, but that would just make me or someone else with a tolerance cranky.
 
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