DJHENRU
Bluelighter
Im not sure if this is basic/other/advanced or what.
What does it mean when different routs of administration have the same time that peak plasma levels occur?
In regards to methamphetamine, I read in one study ingestion and smoking both peak at hour 2.
This was explained as "because smokers have inhaled vapor that still is taken through the body like ingestion, but through the mucous membranes of the respiratory tract."
Is this still correct with Iv or other ROAs? I began to think could it's metabolites play any significant role at all?
I know there are variables with ROAS changing bioavailability, and that their active routs are not all linearly the same potency or excretion rate. I'm just wondering about a bit of clarification for methamphetamine.
Can't remember the reference but it seemed a bit dated of a study published by the DOJ, but it caught my attention hosted on some Mexican domain thus I cant find it easily now...
What does it mean when different routs of administration have the same time that peak plasma levels occur?
In regards to methamphetamine, I read in one study ingestion and smoking both peak at hour 2.
This was explained as "because smokers have inhaled vapor that still is taken through the body like ingestion, but through the mucous membranes of the respiratory tract."
Is this still correct with Iv or other ROAs? I began to think could it's metabolites play any significant role at all?
I know there are variables with ROAS changing bioavailability, and that their active routs are not all linearly the same potency or excretion rate. I'm just wondering about a bit of clarification for methamphetamine.
Can't remember the reference but it seemed a bit dated of a study published by the DOJ, but it caught my attention hosted on some Mexican domain thus I cant find it easily now...