Stimulants Peak plazma leveling for methamphetamine? Differences and implications.

[DJHENRU]

Im not sure if this is basic/other/advanced or what.
What does it mean when different routs of administration have the same time that peak plasma levels occur?

In regards to methamphetamine, I read in one study ingestion and smoking both peak at hour 2.

This was explained as "because smokers have inhaled vapor that still is taken through the body like ingestion, but through the mucous membranes of the respiratory tract."
Is this still correct with Iv or other ROAs? I began to think could it's metabolites play any significant role at all?

I know there are variables with ROAS changing bioavailability, and that their active routs are not all linearly the same potency or excretion rate. I'm just wondering about a bit of clarification for methamphetamine.

Can't remember the reference but it seemed a bit dated of a study published by the DOJ, but it caught my attention hosted on some Mexican domain thus I cant find it easily now...

 

[AlphaMethylPhenyl]

Plasma regards blood levels.

Do you have a source?

 

[DJHENRU]

whooo after about 45 minutes of searching http://www.biblioteca.cij.gob.mx/Ar.../Metanfetaminas/Articulos/methamphetamine.pdf
Methamphetamine — Effects on Human Performance and Behavior I'm gonna review it atm(Oh shit, I was confused I think with the ask shulgins article about meth, using 2hrs not 3 but I more so was disregarding the hour # and questioning equitive peak plasma time)

 

[DJHENRU]

Peak plasma amphetamine concentrations after smoking were quite low (around 0.004 mg/L) and again were achieved at around 12±2.3 h after dosing. Approximately 37% of the ingested dose was excreted in the urine as the parent drug, while 7% was excreted as amphetamine.
The kinetics of smoked methamphetamine are quite different in character from those of smoked cocaine, which is absorbed very rapidly with kinetics similar to that of IV administration. The kinetics of smoked methamphetamine more closely resemble that of oral administration. Cook et al. [21] attribute this to subjects swallowing some of the smoked dose, absorption of drug trapped or adsorbed on the mucosa, or the drug being retained in and slowly absorbed from the lungs. This is further compounded by the long half-life of the drug.

I guess it maybe makes sense with norepinephrine somewhere between DA and sertonin...