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PEA: In absense of MAO, DARI or Releaser?

while i have seen reports to the contrary in other users (no effect at doses of this nature and higher) individual response will vary considerably and indeed being a substrate itself for MAOB I have no doubt for most every person there exists a threshold dose where characterisitc effects akin to this nature will be realized

It is basically a form of entourage effect, though usually the term is used fo a co-substrate that differs from the active to be 'protected' by the entourage that are the sacrificial lambs, but being cheap and readily available it is well suitable as its own entourage substrate
 
samadhi_smiles said:
if you IVed this substance at a high enough dose would the high feel like IV amphetamine?
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Probably not, as MAO-B is primarily concentrated in the brain, where PEA is rapidly oxidized. I.V. administration is indicated when poor absorption in the gut (where MAO-A levels are significant) is the primary pharmacokinetic issue.

As to the original topic, I doubt PEA would exert much effect in the brain sans an MAO-B inhibitor, and taking large amounts would most likely result in increased oxidative stress in the brain.
 
I steadfastly agree with the comments of fastandbulbous in that experience reports are not sufficient evidence to establish the efficacy of any drug or supplement. The placebo effect in these instances is often highly under-rated. The experience reports presented by NeuronalPerception, in my opinion, are nothing more than a viral marketing attempt.
 
Until I see legitimate studies, I'm going to chalk this up to placebo and stupidity...
 
Gaian Planes said:
if you IVed this substance at a high enough dose would the high feel like IV amphetamine?
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with anything else? this is interesting can u give us some more details?

cause from PIHKAL:
DOSAGE: greater than 1600 mg.

DURATION: unknown.

QUALITATIVE COMMENTS: (with 200, 400, 800 and 1600 mg) No effects.

(with 500 mg) No effects.

(with 800 and 1600 mg) No effects.

(with 25 and 50 mg i.v.) RNo effects.
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half of RC's? More than half, if you count the amphetamines/cathinones!

Substituted phenethylamines are not attacked by MAOI's as aggressively as PEA itself, and often produce completely different effects than we'd expect from PEA.


http://www.bluelight.ru/vb/showthread.php?t=388413

Looks like some people find it to be active
 
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Well, there are the tryptamines, too, and there haven't been many amphetamine RC's, and only a few cathinones. Still, I agree the roughly half number.

The dimethoxy phenethylamines have limited dopaminergic effects and are fairly selective for 5HT2a.

Since I posted this way back when, I bought 10 grams of beta phenethylamine and two months worth of selegiline.

beta-phenethylamine is an amazing drug that is intensely euphoric, it felt very very smooth, like dextroamphetamine, really. Actually, I enjoyed it more than any other stimulant I've ever done, I think. I have a hard time thinking of any I liked nearly as much. oddly, dexmethylphenidate is up there.

Anyway, it was like amphetamine crack before I overdosed and ended up quite ill from it. It took about 2.5-3 months before my heart went totally back to normal, and for the first few weeks, even climbing the stairs would cause it to race.
 
I want to ask you, Is dangerous to take phenylethylamine + MAO-B inhibitor (in terms of toxicity for the body and brain) in a longer time period ? What are the dangers effect on body to has(for to redosing few times per day) ?
 
Are we talking about dangers as in toxicity, neurotoxicity, or something else?

1. I used ten grams over two months. A recent IQ test shows no change. No increase either, but that's all I could hope for.

2. Neurotoxicity is likely to be about the same as amphetamine. The more you use, the worse it'll be.

3. Effects on blood pressure were very minimal. Heart rate wasn't effected until I had a serious overdose, and then it went up way high. Still, I think it's generally better than amphetamine in this area, but overdoses are overdoses, and if you get too high, you're dead.

4. Being that you're taking it with an MAOI, odds are good that it's actually safer in terms of neurotoxicity than other stimulants under normal conditions. Much of the neurotoxicity from dopaminergic stimulants is thought to stem from increased oxidative stress. You won't have much of that if you're taking MAOIs.

5. I have no idea how this applies if you're taking a nonselective MAOI, but I have heard bad things.
 
Hammilton said:
2. Neurotoxicity is likely to be about the same as amphetamine. The more you use, the worse it'll be.
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in addition to the antioxidant effects of selegiline and co. PEA has no measurable affinity for 5HT receptors while amphetamine does (though its very low) i could imagine selegiline+PEA used responsibly (which may be impossible (so lets say hypothetically)) could be safer than an equiv. dose of adderal.
 
5. I have no idea how this applies if you're taking a nonselective MAOI, but I have heard bad things.
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All of the reports of this combination that I've come across involve a frightening but non-fatal overdose, with some hospital visits among them.

selegiline+PEA used responsibly (which may be impossible (so lets say hypothetically))
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I would class it as very difficult but possible. Short acting stimulants are difficult to avoid over-redosing.

ebola
 
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