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PD's Big & Dandy 5-IAI Thread

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having been sent one lot of bunk stuff I got a different lot of stuff from elsewhere, and frankly this stuff smells almost exactly the same as some 4-fmc (flephedrone) I had got a while back. even as far as being extremely stinky from long range. 4-fmc would also kind of explain the almost getting there but not quite feeling other people have described. I know smell isn't a meaningful way of identifying a substance, just passing on what my sense of smell is telling me.
 
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For all those wondering, I didn't start straight off with a 2/3 day bender consuming nearly 4/5 grams - if you read the earlier reports I began with 15mg and worked my way up.

I can only trust the original vendor I got it from, the rest have just sent me inert compounds of crap. Anyway it will be interesting to know the results of the police testing (assuming they just don't say "nah, it's legal") because they will be using GC/MS or NMR. I should know by early July according to them.
 
Mmm, not promising is it....

just rec'd 5g of a bag labelled 5-IAI not for human consumption.It comes froman internet vndor who sells many products, so i guess they are pretty established and known and hopefully do not want to ruin their reputation. If this is completely crap,will I be able to reveal the source as a warning o leave it alone? If it is OK I won't reveal the source.

Anyway i have a job on this afternoon but then I will try it out.

for now appearance -fine white powder
Smell - mild, nothing I recognise. Maybe just smelling the bag a few times wil serve as the preliminary step. Next step around 5pm will be a tiny taste. 6pm - 20mg.
 
I sent the vendor an e mail regarding my concerns after reading this thread and others. He replied

You're welcome to get it tested and I'd like to hear the results........we brought a small sample amount from a lab we've worked with for a while so do trust them! We only managed to get a small amount as they're still working on scaling up production.


I researched the product myself before selling and find the effects are good and what was expected.

Mmm still looks like I am going to have to suck it and see. but the response gave me a little more confidence.
 
Would be nice if this were the real deal though I am not exactly expecting much. Pretty sure the laws here in Australia do not cover this paticular substance so I will have to triple check before I do decide to order some from overseas.
 
The non-experienced people doing this kind of thing are completely reckless. Surely your lives are worth taking a test to find out exactly what is in the chemical? Or even to wait until other people do these tests and report them. Lets all just watch the world cup until the real deal comes.. :L
 
Think I've got some 5-IAI from the same vendor and it seems to be pretty good!! Not outstanding or better then MDMA but defo worth more research!! Get the urge to re-dose regular tho ;-(
 
Am I correct in thinking that any compound that doesnt act as an agonist at 5ht receptors, such as the aminoindane compounds will ever have potential to explore variations on the mdma "magic" theme? It seems to me like dopamine, ne, and 5ht transporter affinities though definitely have the potential to be euphoric stimulants and psychedelics, alone don't make for a magical entactogen. However since at least one study seems to link the heavy oxytocin release to the euphoric qualities of mdma and the oxytocin release is theorized to be connected to mdma's direct 5ht agonist qualities, the transporter affinity ratios could well not mean a whole lot. I'd guess aet would substitute for mdma in humans more than any aminoindane. I'd guess that any compounds which possess mdma's magic outside of the PEA and Tryptamine structures are a few years away if they exist at all. I'm far from the knowledge level of many on this forum, but it seems to me like the levels of specific receptor affinities as an agonist as opposed to transporter affinities of these compounds are crucial. That doesn't mean they don't have value, but I get the impression many here want to explore variations on that theme of relaxed openness that mdma brings, and I don't know if that's possible with just neurotransmitter releasing agents. If someone who knows more about the subject could speak about this I'd appreciate it.

Also, from what I gather, and again perhaps totally wrong, 5-iai was developed to test for neurotoxicity in the aminoindanes since it is the aminoindane version of the highly nueorotoxic lab standard 4-iodoamphetamine. I thought it wasn't really intended to directly explore the SAR of mdma substituting compounds, even if it does substitute for mbdb.
 
Turing Machine said:
Am I correct in thinking that any compound that doesnt act as an agonist at 5ht receptors, such as the aminoindane compounds will ever have potential to explore variations on the mdma "magic" theme?
Click to expand...

yes, it doesn't seem to

It seems to me like dopamine, ne, and 5ht transporter affinities though definitely have the potential to be euphoric stimulants and psychedelics, alone don't make for a magical entactogen. However since at least one study seems to link the heavy oxytocin release to the euphoric qualities of mdma and the oxytocin release is theorized to be connected to mdma's direct 5ht agonist qualities, the transporter affinity ratios could well not mean a whole lot. I'd guess aet would substitute for mdma in humans more than any aminoindane. I'd guess that any compounds which possess mdma's magic outside of the PEA and Tryptamine structures are a few years away if they exist at all. I'm far from the knowledge level of many on this forum, but it seems to me like the levels of specific receptor affinities as an agonist as opposed to transporter affinities of these compounds are crucial. That doesn't mean they don't have value, but I get the impression many here want to explore variations on that theme of relaxed openness that mdma brings, and I don't know if that's possible with just neurotransmitter releasing agents. If someone who knows more about the subject could speak about this I'd appreciate it.
Click to expand...

yes, but mdma is also a poor 5ht2 agonist. its active metabolite mda seems to be where that effect stems from.

Also, from what I gather, and again perhaps totally wrong, 5-iai was developed to test for neurotoxicity in the aminoindanes since it is the aminoindane version of the highly nueorotoxic lab standard 4-iodoamphetamine. I thought it wasn't really intended to directly explore the SAR of mdma substituting compounds, even if it does substitute for mbdb.
Click to expand...

it was, nichols lab was interested in this specifically which was why they did the animal discrimination studies unlike most of the other serotonergic neurotoxin research studies completed in the 60's and 70's. it does have application eg pain relief or as an antidepressant. mdma is a great antidepressant but is problematic because of the inability to redose, neutoxicity etc
 
AFAIK, the drug hasn't even reached the United Kingdom yet. A mate of mine who sold a lot of Mephedrone is currently out in India which is one of the areas where they are going to be producing the 5-IAI. He has only just received his sample packs which he is going to send back to us and try himself (although they are in pill form not powder).

The powder based form he will have soon and will be getting back into the United Kingdom in the next few weeks. I'm not sure if this is the same overall for everybody, but judging by the posts on this forum so far I'd say that there is no 5-IAI in the country yet.

He'll update me on how his pill goes and I can update here if you would like.

It's just a waiting game I think lads.
 
Turing Machine said:
Am I correct in thinking that any compound that doesnt act as an agonist at 5ht receptors, such as the aminoindane compounds will ever have potential to explore variations on the mdma "magic" theme? It seems to me like dopamine, ne, and 5ht transporter affinities though definitely have the potential to be euphoric stimulants and psychedelics, alone don't make for a magical entactogen. However since at least one study seems to link the heavy oxytocin release to the euphoric qualities of mdma and the oxytocin release is theorized to be connected to mdma's direct 5ht agonist qualities, the transporter affinity ratios could well not mean a whole lot. I'd guess aet would substitute for mdma in humans more than any aminoindane. I'd guess that any compounds which possess mdma's magic outside of the PEA and Tryptamine structures are a few years away if they exist at all. I'm far from the knowledge level of many on this forum, but it seems to me like the levels of specific receptor affinities as an agonist as opposed to transporter affinities of these compounds are crucial. That doesn't mean they don't have value, but I get the impression many here want to explore variations on that theme of relaxed openness that mdma brings, and I don't know if that's possible with just neurotransmitter releasing agents. If someone who knows more about the subject could speak about this I'd appreciate it.

Also, from what I gather, and again perhaps totally wrong, 5-iai was developed to test for neurotoxicity in the aminoindanes since it is the aminoindane version of the highly nueorotoxic lab standard 4-iodoamphetamine. I thought it wasn't really intended to directly explore the SAR of mdma substituting compounds, even if it does substitute for mbdb.
Click to expand...

Makes me want to investigate 4-oh-aet, actually, just to play with receptor affinity.
 
It would seem 5-IAI is being shipped to the country, and has been for a while now. Customs are seizing all the shipments and only the odd few are slipping though the net. This might be because they anticipated its potential to be a half decent drug.

I get the feeling that a new policy on drugs is being written up as we speak, probably very similar to the one being introduced in Ireland which will effectively wipe out sales of all psychotropic substances. Customs may be attempting to hold onto these chemicals until new legislation is introduced so they can 'destroy' the seized goods without having to give them back.
 
I have been told that no bulk quantities have yet been produced or shipped anywhere yet and there certainly isn't anyone selling it so far. Customs can't seize legal goods on the offchance that they may be banned at some point in the future either.
 
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