Chris Timothy
Bluelighter
Anyway, I don't want to give off blatant junkie vibes, so let me explain the reasoning why I've got myself some O-PCE. I'm honestly not interested in its recreational effects at the moment, which are inferior to DMXE's. Holing on it had become horrible at the end, and the sleep deprivation has gotten me into general, unacceptable trouble before. I'm purely interested in the threshold or even sub-threshold dosages.
One reason it its effect on the tinnitus. There's some phase in its effect development where it kills the tones, and I wondered whether I could somehow shoot for that. Yesterday's experiment didn't yield promising results though.. even though its own crystalline noise profile provides some masking for the much more annoying kratom tone. (Edit: and it does kill the ear ache, the most physical and probably most primary factor in my whole tinnitus cascade mechanism, more effectively than Ginkgo Biloba.)
Second reason is mood. The kratom tone had been subtly killing it more than I'd like to admit. So bloody much effort to kill it a couple years ago, and now it's back. Infuriating. But so it occured to me that O-PCE could be suited for the Jamshyd/Foreigner protocol. The fact it lacks the balance of MXE doesn't matter at minute levels, nor that it lacks the ketamine psychedelia, for the same reason. It's more potent, and has a vastly longer duration, making it less of a hassle to keep up the threshold effect. Worth the investigation, I'd say.
Third is tolerance. I don't think that's worth investigating, but barring the ethics it can be mentioned as a scientific curiosity. I did read one paper on rat studies (before I concluded I probably shouldn't drum up too much interest in this) documenting how down-/upregulation of NMDA receptors is dose-dependent. Could it be that microdosing would actually lower tolerance towards recreational dosing? Actually I realize now I've got that backwards. If tolerance would indeed be reflected just in down/-upregulation of NMDA receptors, holing doses would make low doses more effective afterwards, which we know from experience it doesn't. But so that was my (faulty) thought process, it thought it would be of some interest to check tolerance for normal doses before and after a microdosing period.
But so that's my reasoning behind this move. I had to do something about the bloody kratom tone, and thought I'd do something else than the tedious keto. Reasons one and three are a bit shaky and I do feel like a bit of moron because of it now. But I do think reason two justifies the move. If it works then it counts as scientific progress.
Edit: Also, I had an inflamed back muscle or sumn from trying to up the exercise routine combined with the erhm.. creative ergonomics I have for living in a trash pile. O-PCE seems to have taken care of that. I mean it was already healing, but now it's unexpectedly completely gone. Hurray for that I guess.
One reason it its effect on the tinnitus. There's some phase in its effect development where it kills the tones, and I wondered whether I could somehow shoot for that. Yesterday's experiment didn't yield promising results though.. even though its own crystalline noise profile provides some masking for the much more annoying kratom tone. (Edit: and it does kill the ear ache, the most physical and probably most primary factor in my whole tinnitus cascade mechanism, more effectively than Ginkgo Biloba.)
Second reason is mood. The kratom tone had been subtly killing it more than I'd like to admit. So bloody much effort to kill it a couple years ago, and now it's back. Infuriating. But so it occured to me that O-PCE could be suited for the Jamshyd/Foreigner protocol. The fact it lacks the balance of MXE doesn't matter at minute levels, nor that it lacks the ketamine psychedelia, for the same reason. It's more potent, and has a vastly longer duration, making it less of a hassle to keep up the threshold effect. Worth the investigation, I'd say.
Third is tolerance. I don't think that's worth investigating, but barring the ethics it can be mentioned as a scientific curiosity. I did read one paper on rat studies (before I concluded I probably shouldn't drum up too much interest in this) documenting how down-/upregulation of NMDA receptors is dose-dependent. Could it be that microdosing would actually lower tolerance towards recreational dosing? Actually I realize now I've got that backwards. If tolerance would indeed be reflected just in down/-upregulation of NMDA receptors, holing doses would make low doses more effective afterwards, which we know from experience it doesn't. But so that was my (faulty) thought process, it thought it would be of some interest to check tolerance for normal doses before and after a microdosing period.
But so that's my reasoning behind this move. I had to do something about the bloody kratom tone, and thought I'd do something else than the tedious keto. Reasons one and three are a bit shaky and I do feel like a bit of moron because of it now. But I do think reason two justifies the move. If it works then it counts as scientific progress.
Edit: Also, I had an inflamed back muscle or sumn from trying to up the exercise routine combined with the erhm.. creative ergonomics I have for living in a trash pile. O-PCE seems to have taken care of that. I mean it was already healing, but now it's unexpectedly completely gone. Hurray for that I guess.
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