Xorkoth
Bluelight Crew
I just found that entry and wow, that's quite interesting. I'm surprised that's not talked about more. I was also able to find a study Shulgin did with radiolabled DOI and they found the same sort of accumulation in the lungs, but it didn't occur with radiolabled 2C-I.
If there is an active metabolite I wonder what it would be. I was able to find a study that showed the primary metabolite of DOB was 2-methoxy-5-hydroxy-4-bromoamphetamine, but this metabolite still only reached plasma levels about 20% of what DOB reached. Are you aware if Shulgin ever experimented with 5-hydroxy phenethylamines? All that said, it still seems reasonable that the DOx compounds would be active in their own right considering they are extremely high affinity agonists at the 5-HT2A receptor.
Yeah I really don't understand what's happening with the DOXs. I wonder if Shulgin was speculating about the secondary metabolites? It does seem clear they go to the lungs before reaching the brain. Or maybe they also go to the lungs? Not sure if anyone really knows, but it goes to show that the total picture of what goes on with mind-altering drugs is really not as clear as we like to think.