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☮ Social ☮ PD Social: Cross-dimensional chatter. Now featuring mesphereomeantoliopeme.

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Cyanoide said:
What are you people up to today (or rather tonight here)?
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Slept in, gotta go down to Anaheim to pick up sister since that's as far in this direction the train'll take her. And good news, money coming my way so I do in fact actually get something for my birthday, hells yeah. I'm counting down the days, haven't indulged in opiates since first week of January, and strong stims since November. Maybe I'll get me a fine-ass cigar while i'm at it, been sticking with pipe tobacco so far this year since the $16 worth I bought a ways back lasts me several months. =D

I'm all about life's simple pleasures. Lucky day, oh happy day~

Edit: maybe not so lucky, wore new shirt for first time today (it was free, used, but new to me) and spilled bleach on it. Now it's ruined...
 
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PepperSocks: I had thought about much the same idea re: DMT ;) heh heh. It might be intriguing to splice in a control region for the production of MAO, too. (kinda risky doesn't even come close to expressing the danger this entails though!)

In regards to yeast, aromatic L-amino acid decarboxylase will turn tryptophan into tryptamine no problem! But you knew that already :) . (more for the benefit of others)

I still don't see why you need a eukaryote despite your explanation, too (good catch though; I need to read more carefully. Transcription looks pretty similar to translation). Sure, mRNA needs cutting up, that is if you want to read all the relevant proteins from one region in one go. But, can't you do that manually (see where what starts and what ends), then just insert all the relevant genes with their own promoter sequences in a prokaryote?
 
Could someone recommend a good introduction book for a better understanding of the pharmacology behind psychoactive compounds? The book doesn't have to focus on psychoactive compounds, if it would just help with a better understanding about them.
 
^PiHKAL is teaching me a lot, for sure.

Also, Shpongle show in 6 days ahhhh adlsajfksgk my brain.
 
MattPsy said:
PepperSocks: I had thought about much the same idea re: DMT ;) heh heh. It might be intriguing to splice in a control region for the production of MAO, too. (kinda risky doesn't even come close to expressing the danger this entails though!)
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Oh ya, I'm totally against intentionally modifying the human genome. It leads to scary shit. Lots of people have genetic diseases or improvements that are caused by mutations. I was just thinking what it would be like if someone got a 'gain-of-function' for DMT synthesis (like people who have gain of function mutations for hemoglobin production, they're amazing marathon runners), I would never advocate purposely inducing such a thing.

In regards to yeast, aromatic L-amino acid decarboxylase will turn tryptophan into tryptamine no problem! But you knew that already :) . (more for the benefit of others)
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Good catch, I didn't think of that. You'd also have to suppress any MAO producing genes though.

I still don't see why you need a eukaryote despite your explanation, too (good catch though; I need to read more carefully. Transcription looks pretty similar to translation). Sure, mRNA needs cutting up, that is if you want to read all the relevant proteins from one region in one go. But, can't you do that manually (see where what starts and what ends), then just insert all the relevant genes with their own promoter sequences in a prokaryote?
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Look it up; it's the main reason why people use yeast for things where E.Coli would be more practical. Another avenue would be cDNA. It's the process of isolating mescaline producing cells from trichocereus, extracting the (already functional, spliced) mRNA and converting it to DNA with reverse transcriptase. That way the cDNA (c stands for complementary) has the genetic code for the mRNA that requires no splicing of exons.

Look up the processes of DNA recombination and it'll become more clear. It's really not all that complicated.

TheAppleCore said:
^ Damnit, I really wish I could participate in this discussion. Looks like some fascinating stuff.
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Same to you, look up 'recombinant DNA' and the processes behind producing it. It's not that hard. Other people such as an awesome LSD user, Kary Mullis, did all the hard work figuring the shit out.
 
^ Thanks. :)


Wow. Hm. Is it the new batch, or is it me? This MXE is really blowing my mind. Fucking beautiful. Reminds me of DMT in its deep spiritual capacity.
 
Cyanoide said:
Could someone recommend a good introduction book for a better understanding of the pharmacology behind psychoactive compounds? The book doesn't have to focus on psychoactive compounds, if it would just help with a better understanding about them.
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A good general overview of pharmacology is Bilz0r's Neuropharmacology Text.

As far as 5-HT psychedelics are concerned, IMO the best review is "Hallucinogens" by DE Nichols, Pharmacology & Therapeutics 101 (2004) 131–181. The last 25 pages of the review get really technical, and I've only actually waded through them in their entirety one or two times, but the first 25 or so pages are gold. It covers the subject from multiple academic perspectives, and its really been an invaluable text for me.

Also: "The neurobiology of psychedelic drugs: implications for the treatment of mood disorders" by Franz X. Vollenweider and Michael Kometer, Nature 11 (2010) 642-651. This is an incredible text that covers 5-HT2A agonists as well as NMDA antagonists, also from multiple academic perspectives (but with an emphasis on clinical neuropharmacology).

Axed said:
^PiHKAL is teaching me a lot, for sure.
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Don't get me wrong, PIHKAL is one of my favorite books ever. But its not really pharmacologically relevant; its more in the tradition of the medicinal chemist, who is primarily concerned with producing a series of compounds and evaluating how changes in structure effect the resultant activity. Its great if you're primarily interested in the chemistry, but the question of how the compounds interact with the human receptorome is a different subject entirely.
 
Roger&Me said:
Don't get me wrong, PIHKAL is one of my favorite books ever. But its not really pharmacologically relevant; its more in the tradition of the medicinal chemist, who is primarily concerned with producing a series of compounds and evaluating how changes in structure effect the resultant activity. Its great if you're primarily interested in the chemistry, but the question of how the compounds interact with the human receptorome is a different subject entirely.
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Ah okay, thanks for the clarification sir!
 
Thanks for the recommendations regarding books, I'll definitely check them out. The relationship between the brain/mind and chemicals has been increasingly interesting, but I know far too little about it, which frustrates me.
 
I'm a liar and self-deceptive. I was just too weak to hold my promise of not touching stimulants again. Or maybe it's just a sign they have their place in my life too. They don't mean much to me like psychedelics do, but if my mind wants them every now and then, I maybe shouldn't punish myself by feeling too guilty about it. I'm not a masochist and enjoy hedonism every now and then.

Gosh this ethylphenidate is euphoric. It's hard to say I hate stims when feeling this good. I guess I can grant moments like these for me occasionally. But the emphasis is really on occasionally.
 
When you don't talk to your people for 4 months, they change their phone numbers on ya...Darnit, I have money finally, but can't spend it (aside for the half of it I immediately blew on premium cigars and fancy liquor...). Actually it's kind of funny I think. 8)

How's PD doing? Major verbal abuse going on over here from the owner of the house's favorite tenant, so I gotta take it quietly, which I'm good at, but my blood pressure's way up, and I'm gettin' much indigestion and bruxism. Booze and cigars will be very nice to me.


TAC said:
Maybe finish up this book on Taoism I've been slowly chewing on
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What book is it/what is it about precisely? Taoist thought has had more than a little influence on my thinking, and I throw the Yi Jing every so often when I'm in need of direction.
 
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Cyanoide said:
I'm a liar and self-deceptive. I was just too weak to hold my promise of not touching stimulants again. Or maybe it's just a sign they have their place in my life too. They don't mean much to me like psychedelics do, but if my mind wants them every now and then, I maybe shouldn't punish myself by feeling too guilty about it. I'm not a masochist and enjoy hedonism every now and then.

Gosh this ethylphenidate is euphoric. It's hard to say I hate stims when feeling this good. I guess I can grant moments like these for me occasionally. But the emphasis is really on occasionally.
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I did the same thing, I took a lot of benzos and opiates in the last few days, and then amphetamine again today. I'm not too proud of myself. Addiction is rearing it's head on me, at last. :(

I've been using hard drugs moderately for so long and thought I would do so consistently, but I think I've crossed into the region of 'requiring it'.

EPH is very euphoric, but it has a hell of crash and doesn't last too long. My favorite use for it is when I'm watching a movie on opies/benzos and I can't keep my eyes open; I'll take an EPH bump and it'll keep me going for another couple hours without keeping me awake late.

Never Knows Best said:
How's PD doing? Major verbal abuse going on over here from the owner of the house's favorite tenant, so I gotta take it quietly, which I'm good at, but my blood pressure's way up, and I'm gettin' much indigestion and bruxism. Booze and cigars will be very nice to me.
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That sucks man. I can sort of relate. Where I live is rather noisy and I somewhat attribute my high stress level (and symptomatic drug use) to it. Tonight, on a monday, one of my roommates friend's is over drinking with some other friends. I'm in for another noisy night I think.

Catch-22: If I have my own place I have peace/quiet, loneliness, get good grades. Living with others; I have social interaction, but noise, stress, and lower grades.
 
Had the most wild 2mg 25i-NBOMe experience on Saturday in Florida. Houses were changing color, maximum sensory overload, hexagonal water ripples due to some rain, planes flying in the sky were multiplying and bursting into flames. Absolutely amazing time with a fellow staff member =D Found some serious depth to this chemical, got stuck in crazy thought loops and had some insight into what roles certain people fill in my life :)
 
PepperSocks said:
I did the same thing, I took a lot of benzos and opiates in the last few days, and then amphetamine again today. I'm not too proud of myself. Addiction is rearing it's head on me, at last. :(

I've been using hard drugs moderately for so long and thought I would do so consistently, but I think I've crossed into the region of 'requiring it'.

EPH is very euphoric, but it has a hell of crash and doesn't last too long. My favorite use for it is when I'm watching a movie on opies/benzos and I can't keep my eyes open; I'll take an EPH bump and it'll keep me going for another couple hours without keeping me awake late.
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When I stopped using drugs because my mental health collapsed many years ago I swore not to take stimulants again. Most harm was done by MDMA though, but the speed was always there too and had a major role in causing mental problems. Now I've gone a long and painful path to a quite good recovery, although I still have some mental problems. That's why I'm a bit afraid I may ruin so much of what I've achieved. Granted, my doses are quite smal, I don't party anymore, I don't binge, I try to sleep enough and eat healthy and always take antioxidants and vitamins with stimulants. I don't think there's a risk of getting addicted, I usually flush the stims down the toilet if I use too often. But on the other hand that itself tells that I easily get addicted. But I try to be very aware of how often I take stims. I overdid MXE and can't enjoy it anymore. Everything that has a quite high addictive profile is risky for me.

The "problem" with me is I how so much stuff to ease crashes and comedowns because I've been prescribed so much drugs the last 7 years. And I still have lots of prescriptions that I haven't even used. So I don't really have to worry about comedowns or not getting sleep. Last night I took 60 mg mirtazapine which completely removed all effects of EPH. I felt warm and fuzzy, even slightly euphoric. There was not a hint of anxiety anymore (I easily get anxious and panicky with EPH, MPA and speed don't make panicky) and then the mirtazapine knocked me out. Slept for 6,5 hours and, while I was very groggy the first hours at work today, I'm fortunately alone at the office this week. Today I've just snorted EPH lines and done some otherwise boring stuff.

Do you use amp for functional or recreational purposes? Or both?

I long for psychedelics. Next week is fortunately Easter and there's plenty of time for some major tripping :)
 
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Is there anywer i can talk about etizolam experiences on here???? took loads but no effect. this site is confusing? maybe cos am o mex rite now dont no. i need anti anxiey stuff without seing a doc. HHHHHEEEEEEEEEEEELLLLLLLLLLLPPPPPPPPPPPP!!! wer am I????????????
 
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