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Opioids Oxytrex (oxycodone and naltrexone in a pill)

lozgod said:
it is hard to imagine 100,000th of a dose relative tot he oxycodone dose having any effect but it does. Also they claim to eliminate dependence (literally in a day for short term addiction)

http://www.annieappleseedproject.org/ullownaltopr.html



I ordered some Naltrexone. I am going to try it. My plan is as follows.

1. Use 100,000th the naltrexone alongside the oxycodone dose for 2 weeks in an attempt to defeat the physical dependence.

2. Assuming that works then go on low dose naltrexone (3mgs at bedtime) to jump start natural endorphins.

The difference between using 3mgs vs 50mgs is they both cause a 200-300% increase in endorphins in almost all subjects but the low dose only blocks the receptors for up to 4 hours while the increase in endorphins lasts over 24 hours whereas the 50mg dose would block the receptors for 28 hours therefore never receiving the benefit of the increase.

If the addiction reversal doesn't work then I am going to man up and stay sick for 72 hours after tapering as low as possible in an attempt to not experience PW.

This may actually be the cure to opiate addiction.
Click to expand...

Please give results. This is interesting stuff, although I'll keep skepticism around. ;)
 
BaybeX said:
0.026mg Bupe = 0.260mg Oxycodone.



Seriously? Come on, dude.
You're either 12lbs or you have a serious needle fetish.
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Some people are more/less sensitive to certain drugs than other people are.

Also, from what I gather about people with a "needle fetish", they wouldn't waste most of their dope snorting it.

Finally, converting doses of buprenorphine to full agonists is not exactly easy to do; buprenorphine isn't like full agonists. It would be easier, and more accurate, to convert doses of full agonists to other full agonists.
 
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Yes, some people are more sensitive. When I didn't have a tolerance.. I could feel 5mgs of Oxy.
But there is NO WAY in Hell that anyone, especially a past addict, can feel 1/5 of a milligram of Oxycodone.

As for the second thing you said.. What does that have to do with anything? I said nothing about snorting, lol.
 
^Thanks for the update.

I don't need you to reply to posts intended for him.
I am fully fucking aware that Bupe is not Oxy. Thanks for that.

And yeah, C.H used to snort his dope. Okay?

I'm done derailing your thread, OP. My apologies.
 
Few points I would like to make regarding this.

1) There will NEVER be a cure to "opiate addiction". As long as there are opiates, there will be people addicted to them. You could take suboxone and taper, take ULDN, or just go cold turkey. That may make you no longer experience cravings or physical side effects of cessation of opiates, however, that will not "cure" opiate addiction. If a person wants to get jammed, surprise, they will get jammed.

I have read several articles on this topics, and it looks interesting in reversing/halting opiate dependance, however, I would like to see more studies done with humans, and higher phase trials, before passing a final judgement on uldn. Additionally, I wonder what the cost would be, a naltrexone detox is extreamly painful.

2 side notes on naltrexone, feel free to skip.
NSFW:

1) Naltrexone is a very archaic drug. People have the drug implanted into them, to constantly release, preventing people from ever doing opiates. This is wrong for a few reasons. First, if people want to do opiates then they should be able to, we should have forced medicine. People shouldn't be looked at as such scum bags that they need to inject a drug to make them extramely sick inside them to prevent opiate use.....isn't it sad that one of the "side effects" of opiates is Euphoria - we live in a world where Euphoria is a BAD THING!


Side effects.....coughing, sneezing, aches, loss of limbs, death, anal bleeding, infertility, euphoria, aids, canceer, decapatation.

^^^Seriously WTF.

2) I believe naltrexone pills come in 50mg. I took 1 one night, my rational was that I didn't want to keep spending money on heroin, so I would just take some, speed up the withdrawals, and be done with them really fast.....how wrong was I. I got SO sick, worse than any heroin withdrawals I had ever experienced. I was contemplating the quickest way to commit suicide.

Just some anecdotes on naltrexone.
 
wow. this is really cool. Ultra low doses of antagonists actually attenuating tolerance. i will be very interested to see how this goes. ultimately, this is evergreening but fuck if it works it will supercede that motivation in the ramifications.
 
"Evergreening"?

JamtasticX said:
Few points I would like to make regarding this.

1) There will NEVER be a cure to "opiate addiction". As long as there are opiates, there will be people addicted to them. You could take suboxone and taper, take ULDN, or just go cold turkey. That may make you no longer experience cravings or physical side effects of cessation of opiates, however, that will not "cure" opiate addiction. If a person wants to get jammed, surprise, they will get jammed.

2 side notes on naltrexone, feel free to skip.
1) Naltrexone is a very archaic drug. People have the drug implanted into them, to constantly release, preventing people from ever doing opiates. This is wrong for a few reasons. First, if people want to do opiates then they should be able to, we should have forced medicine. People shouldn't be looked at as such scum bags that they need to inject a drug to make them extramely sick inside them to prevent opiate use.....isn't it sad that one of the "side effects" of opiates is Euphoria - we live in a world where Euphoria is a BAD THING!
Click to expand...

1) True only in a sense - it is unfortunate that the euphoria can't be decoupled from the physical effects that lead to physical withdrawals. It is, imo, pessimistic to deny that there may some day be opiates that produce tolerance/addiction more slowly, or that methods to make the withdrawal profile less unpleasant.

2) And is everyone who is given naltrexone to prevent them from using forced to do so? Are there not people who elect to get that treatment because they know they lack the willpower to avoid using opiates, and want to stay clean? I agree that people should be free to take whatever drug they want, but also to receive treatment that will prevent them from using a drug that they can't control themselves with.

And - Yes, euphoria is a sideffect in a therapeutic context - if you are taking opiates to stop pain, so you can continue with your life, you don't want something that will distract you from your goals and other activities.
 
bagochina said:
Sounds like what they did with Talwin back in the day, and that drug has cooincidentally fallen off as a drug of abuse. I forget the mix in that pill naloxone not naltrexone though, now I think its Talwin NX.

Most likely its in there to prevent abuse or to scare ppl into preventing abuse. I could be wrong though...

peace,
seedless
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It is not talwin, 1 brand I read about is Remoxy. It has oxycodone and naloxone 1mg. It did not list the dosages. This is made by King Pharmaceuticals. I also read that there will be more than one different companies that make the same brand, different name.
 
^He's not talking about the Oxy/Naloxone formulation.. Talwin NX is Pentazocine/Naloxone.

Talwin used to be a drug of abuse, but once they added the naloxone it eventually fell off the map in the junkie world. He was just saying that he suspects this may happen with the Oxy/Naloxone combination.
 
BaybeX said:
^He's not talking about the Oxy/Naloxone formulation.. Talwin NX is Pentazocine/Naloxone.

Talwin used to be a drug of abuse, but once they added the naloxone it eventually fell off the map in the junkie world. He was just saying that he suspects this may happen with the Oxy/Naloxone combination.
Click to expand...

I am sorry if my comment sound rude. That what not my intenton.
kicker20
 
TheAzo said:
"Evergreening"?



1) True only in a sense - it is unfortunate that the euphoria can't be decoupled from the physical effects that lead to physical withdrawals. It is, imo, pessimistic to deny that there may some day be opiates that produce tolerance/addiction more slowly, or that methods to make the withdrawal profile less unpleasant.

2) And is everyone who is given naltrexone to prevent them from using forced to do so? Are there not people who elect to get that treatment because they know they lack the willpower to avoid using opiates, and want to stay clean? I agree that people should be free to take whatever drug they want, but also to receive treatment that will prevent them from using a drug that they can't control themselves with.

And - Yes, euphoria is a sideffect in a therapeutic context - if you are taking opiates to stop pain, so you can continue with your life, you don't want something that will distract you from your goals and other activities.
Click to expand...

Perhaps it is pessimistic, and I would agree it would be great if there were opiates that caused tolerance issues much slower.

Of course not everyone who has naltrexone implants, or takes the pill is forced to, they do so as a way to prevent themself from taking other opiates.

I was simply trying to show the archaic nature of the medical system, especially in regards to opiates
 
how did you try it? i thought it was a phase III drug not even approved by the FDA yet.

anyway, adding naloxone to oxycodone would be exactly like talwin nx. it would stop IV abuse for sure....intranasal as well. so yeah, you could still chew it and get it all at once. unless they use a gelling agent and then...yeah it would be abuse proof for the most part.

is anyone old enough that they were around when pentazocine was being abused? was it an epidemic like oxy?
 
this thread is about naltrexone......im confused why so many people are talking about naloxone......other than in comparison to bupe and nal (sub)
 
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