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Oxytocin and MDMA

Ski-bum

Ski-bum

Bluelighter
Joined
Oct 22, 2010
Messages
152
According to this article, oxytocin may be responsible for the loved up feeling you get from MDMA. Not just serotonin and dopamine.

http://discovermagazine.com/2007/jul/this-is-your-brain-on-ecstasy

If that is true, I'd like to try some supplements that restore or even enhance oxyticin levels. I am taking piracetam every day, and 5-HTP for a few days afterwards at the moment. I have ordered 200 grams of choline bitartrate to help absorb piracetam, so I'll take that at least a week before the rolls. Any one know of any supplements I could pick up for oxytocin from my health food store? I read that it is pretty dense in the brain and produced by the liver as well, would a supplement even help?
 
Interesting article. I wish they would say "MDMA" at least once instead of ecstasy, but I'm in part just happy to see an article on MDMA that isn't about how it's killing America's youth. We are still learning a lot about MDMA, given that it's actually fairly new as a popularized drug compared to a lot of others.

Aside from cardiovascular exercise on a regular basis, I do not know of ways to increase Oxytocin than are entirely natural. I hope someone can help you with more info- I'm interested in giving it a try too.
 
Interesting find on the vit C. I actually bring sustained released caps on heavy doses of Vitamin C with me when we're out rolling- I figure it beats a cup of OJ, and it actually seems to have a noticeable impact.
 
its kind of a two-sided sword. because ascorbic acid makes the stomach more acidic. and amphetamines arent absorbed as well in an acidic environment.

but if you take an esterfied form of vitaminC it wont make your stomach acidic, and you'll still get the oxytocin release. idk i'll have to try this next time i roll =D
 
Cool, so vitamin C and exercise are the best ways. I found one doctor's article that says he knows of no supplement that can increase the levels. I know piracetam lowers your blood brain barrier levels so you probably get a better roll with more oxytocin receptors being filled.

So I did some looking, you can buy oxytocin as a perfume and as nasal inhalers that are supposed to boost your confidence and make people trust you. They are all bullshit.

You can apparently get real oxytocin nasal inhalers online for about $50 without a prescription. They are used to increase breastmilk production and initiate birth. The brand name is Syntocinon and it is not dangerous or just for women. It does give social benefits for those who use it but that is not its intention.

How I know the pharamone sprays and confidence inhalers are crap, the pharmaceutical quality stuff must be refrigerated and must be delivered rapidly with an icepack. That means the other stuff is probably using oxytocin that has expired and won't work.

I'd be interested to see if a phamasitical grade oxytocin inahler gives you a poppers like love rush. If any one has extra money to spend, let us know! The halflife in the blood is apparently 3 minutes though, so rushes won't last too long.
 
I don't think that there is any supplements to boost oxytocin levels. I know that eating food releases oxytocin and so does positive interaction. Oxytocin is known to stimulate social interaction and reduce anxiety (both effects of MDMA). Very interesting.
 
Good job, Ski-bum.

Pitocin is commonly used to initiate birth in hospitals, something looked down upon by mid-wives.
Its primary purpose is to speed up labor so the doctor can finish within his/her 12-hour shift. It is used for convenience.
It has been shown to increase risk to the mother and child.

This artificial substitute can cause rapid and violent contractions of the uterus. This increases stress on both mother and child.
If the infant is not in the correct position for delivery, pitocin can cause a bad outcome.

Perhaps artificially increasing oxytocin would NOT have the effect you are looking for.
Dosage and timing are probably critical.
With MDMA, the release of oxytocin and prolactin happens after cortisol levels reach their peak.

This suggests that you would have to administer the oxytocin after you peak.
This might be a risky time to radically alter the balance of things...

Warning:

"Oxytocin has been shown to have an intrinsic antidiuretic effect, acting to increase water reabsorption from the glomerular filtrate. Consideration should, therefore, be given to the possibility of water intoxication" - http://www.drugs.com/pro/syntocinon.html

The best approach would probably be to improve your serotonin function, which would result in higher cortisol levels. The release of cortisol is the precursor.

Abstinence from MDMA would surely improve both the cortisol and the oxytocin/prolactin release.
Exercise would improve the effectiveness of abstinence and it may improve the effects regardless of abstinence.
Exercise increases BDNF in the brain, which powerfully augments the plasticity and re-sprouting of serotonin axons. (thanks Somedud)

Heavy users have been shown to exhibit reduced prolactin repsonse to MDMA even after LONG-term abstinence from the drug. Other serotonin agonists have been tested as well, which backs up this finding.

The BEST way to improve your oxytocin/prolactin is to NOT roll too often.
Many Bluelighters claim the first 5-15 rolls are the most euphoric, and will never return to their original strength.
 
Why do you say the first 5-15? I would argue that the first 1-4 are stronger than the 5th one tbh. I'd say that the first 1-20 times are the best (at least for me), and after that I kind of knew what to expect. The best pill I took, however, was probably around my 40th-50th roll, and I could tell.
 
Ski-bum said:
I am taking piracetam every day, and 5-HTP for a few days afterwards at the moment. I have ordered 200 grams of choline bitartrate to help absorb piracetam
Click to expand...

Really quick... How much choline bitartrate should you take with piracetam? I take piracetam (800mg per capsule) right now and I'm wondering how much choline bitartrate (200mg/500mg??) you need to take with it?

Do you take 500mg of choline at the same time you take 2400mg of piracetam? How much per dosage?
 
Choline is a salt found in the membranes of cells. It is also a precursor to acetylcholine.
Piracetam increases the permeability of these cells, which uses up choline at a faster rate.

Taking choline for days before-hand is what I recommend.
When you take an attack-dose of Piracetam the day of your roll, the choline will be fully available.
Dosage is less important. Take the piracetam several hours before rolling, so it has a chance to work.

Try lecithin.
It contains lots of choline, as well as other great things like inositol and B-vitamins.
I also suggest taking it at least 2 days before-hand.
It reportedly makes you shoot loads like a porn star!
 
Splinters Thoughts, With MasterSplinter

First Bad Comedown said:
Many Bluelighters claim the first 5-15 rolls are the most euphoric, and will never return to their original strength.
Click to expand...

Slow down there Cowboy.

"Many" users have also claimed that after taking a break thats relative to the amount of time using "Many" users will find that ecstasy is re-sparked and feels like their first time again...

You would have to be pretty fucked up to have only the first 5 experience work for you...I suppose you would have to botch or mess up an enema for that.

Heres an example of a user who went a bit to far and has permenantly damaged his brain-gut link forever changing his views on MDMA

First Bad Comedown said:
But, here is my confession: on Halloween I also gave myself a large-volume enema. No shit.

If you must know, it helps the prostate big time by moving the drug all the way through the digestive tract. It also improves the erection. Moving on...

So I think I used too much water and injured myself! For a few days after I even saw blood in my stool.
I use an unbelievable amount of water, even according to my gay friends.
Click to expand...

http://bluelight.ru/vb/showthread.php?t=539153

So be careful...cheers!

-Splinter
 
Lol that guy and his enema. Damn.


I've had a theory that oxytocin depletion maybe has something to do with feeling less cuddly after having sex post-MDMA use.
 
First Bad Comedown said:
Choline is a salt found in the membranes of cells. It is also a precursor to acetylcholine.
Piracetam increases the permeability of these cells, which uses up choline at a faster rate.

Taking choline for days before-hand is what I recommend.
When you take an attack-dose of Piracetam the day of your roll, the choline will be fully available.
Dosage is less important. Take the piracetam several hours before rolling, so it has a chance to work.

Try lecithin.
It contains lots of choline, as well as other great things like inositol and B-vitamins.
I also suggest taking it at least 2 days before-hand.
It reportedly makes you shoot loads like a porn star!
Click to expand...

I see, so you should take lecithin (choline) at least 2 days before rolling... and take piracetam several days before rolling?

Also, what do you mean by "attack-dose"? Sorry, I'm still a bit new here... :\
 
An 'attack dose' refers to a higher dose used on the first day of treatment.
Normally Piracetam comes in 800mg pills, so taking 4 would be a good attack dose.

It is most effective during the first day of use.
Taking Piracetam several days in a row will decrease its effectiveness.
You should take it only on the day you wish to roll.
Just make sure you give it several hours to work.
There are reports that it can ruin a roll if used concurrently with the MDMA.

Choline, or Lecithin, should be used for several days prior, for maximum effectiveness.

Long-term abstinence does return some magic. But heavy users will still claim to never quite recapture the original experience, even after years. They do, of course, still enjoy the experience.

Splinter - its really cute how you follow me around from post to post now.
If you really want, I'll give you an enema of your own.
It can be gentle, unless you like it rough. ;)
 
Wait, I don't see how enemas got in to the conversation?

Yes, Oxytocin is used as a birth aid, ignore the homeopathic paranoia. It is used when labor has started but uterine muscles aren't contracting enough to have a healthy birth. It has saved a lot of women's lives, especially in 3rd world countries where other drugs are not available.

My theory is the body has evolved to use this bonding hormone to trigger birth. If a mother gives birth without the hormone they may reject the child. The hormone also triggers contraction of the uterus after birth to stop bleeding.

There is currently no temperature stable oxytocin available but it is under research in order to provide developing nations with birth aids. Apparently relaxed uterus is a cause of many deaths during childbirth.


A hetero threeway requiring a male enema? I think someone got lucky Pierre with a strapon?
 
Mothers also produce more Oxytocin during their child rearing years. It is what keeps them from choking those little mother fuckers to death.

Maybe we could get a combination drug made that is a benzo and oxytocin together. Talk about a feeling of well being!
 
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