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  • BDD Moderators: Keif’ Richards

Oxycontin (OC) + Tramadol - good safe combination?

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pally pete

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Feb 21, 2010
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Around 20 minutes ago i orally ingested some crushed into fine powder Oxy (160mg) reason being as most you know crushing helps defeat the time-release mechanism somewhat.

Tramadol is'nt a great Opoid when taken alone (imo/ime) it makes me feel a little speedy at times and sometimes nauseas but ive taken 20mg of Promethazine and 10mg Certizirine, many people may ask why takes 2 different, antihistamines, well ime Promethazine usually takes care of nauses and can add a lttle to the sedation (and keeping to a low dose of 20mg) im hoping thsi wont effect any of the Euphoria that 1st generation can sometimes do if you get the dose wrong (imo) and with certirizine being a 2nd genaration i find this particulary good for the itches, which promathazine dosent seem so good at, even at higher doses like 40mg.

Anyway will it be worth me taking any Tramadol to add safely to the experience? What sort of doses? and how to spread the doses out as i know Tramadol in most best by ken of 50-100mg every 30-60 minutes and i dont really have that time as i took the Oxy over 2 1/2 hours ago so im probably over the peak..... Will the tramadol prolonge the Oxy effects? as in hoping to avoid talking more Oxy if possible.

Replies appreciated, thanks.
 
I typically take trams with my oxy as well as it seems to work with the oxy, prolonging and intensifying. This is for me personally but I typically take a 150mg dose with my oxy and the 45min later another 50 mg. Totaling 200 mg total. For me it helps and I have never had an issue other than good ones with tram and oxy.
 
Also yes it is safe to take both at the same time as they effect two different receptors, so they do not interfere with each other. However having those two receptors active at the same time always results In nice effects for me.
 
Does anybody else have anything to add?

Ive read some erowids reports and just wondered if anyone here on Bluelight had any experiences?

I hear the Oxy, Promethazine, Diphenhydramine, cannabis combo works great but just wanted to know if the Tramadol is worthing adding to the mix?

Im hoping it will help intensify the Opiate buzz somewhat because Tramadol on its is a relatively weak Opoid.

Il also be using Diazepam aswell but as most of you know i have massive tolerance to both Benzos + Opiates.

I strongly urge anyone withough a high tolerance to any of the substances i have mentioned not to attempt to mix what i am suggesting.
 
I don't think it's even worth adding Tramadol to the combo. It doesn't potentiate opiates.

Sedative antihistamines are nice for potentiation and help out with the itches from opiates.
 
do you have any history of seizures or does anyone in your family have seizures? tramadol will add to the experience, but i would advise not to go over 100mgs because research has shown that ultram causes seizures.. oxycodone also lowers your seizure threshold; seizures are not fun, trust me.

don't take it at all, or take 50mgs wait 30-45 mins and if you aren't feeling it, take another 50mgs and stop. you are already on a high dose of oxy. the tramadol blocks NMDA, inhibits the reuptake of NE, releases serotonin and binds to serotonin receptors such has 5-HT2c
 
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Mcrt24 said:
Also yes it is safe to take both at the same time as they effect two different receptors, so they do not interfere with each other. However having those two receptors active at the same time always results In nice effects for me.
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That is not correct. There is a danger of combining tramadol with oxycodone, which is that the sedation and respiratory depression may be increased, leading to overdose. It is true that the drugs have slightly different mechanisms of action: Tramadol is a μ-opioid agonist and increases serotonin, while oxycodone is a little less clear. One study found that oxycodone is a κ-opioid agonist, however, this has been disputed, primarily on the basis that oxycodone produces effects typical of a μ-opioid agonist. New research suggests that the effect of oxycodone may affect by different opioid receptors in different situations. Regardless, they are both opioids and I would suggest that when they are taken together one should take a lower dose of each than usual, as there are risks. Tramadol and oxycodone are listed as a serious contraindication which should not be taken without the guidance of a doctor and a tolerance to opioids. Obviously if someone is taking them illicitly they are not going to consult their doctor, but they should be aware that this combination can cause increased respiratory depression, leading to stopping breathing if you take too much. If someone is also taking potentiators with these drugs, that increases the risks even further.
 
if you can still get oc oxycontin i envy you so much in my area all we can get is that op bullshit. Not positive but a good source told me that tramadol ruins an opiate high and if you are in mild withdrawels it will cause precipitated withdrawels wich are much worse.
 
^ a long time heroin addict that i know i just took him at his word and never looked it up, is that bullshit?
 
^Whether it "ruins" an opiate high is a matter of personal preference. As far as causing precipitated withdrawals, that doesn't make sense to me. It is used in treatment centres to wean people off opioids and I have heard about many people using it to alleviate withdrawals on their own as well. Perhaps your friend just doesn't like the effects of tramadol while he is in heroin withdrawal? Perhaps it might be possible that tramadol could slightly speed up the metabolism of opiates and make the opiate leave your system a tiny bit faster, I don't know, I haven't researched that possibility, but even if that were the case that is not the same as causing precipitated withdrawals and it should provide some relief as it is an opioid itself.
 
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weekday warrior said:
if you can still get oc oxycontin i envy you so much in my area all we can get is that op bullshit. Not positive but a good source told me that tramadol ruins an opiate high and if you are in mild withdrawels it will cause precipitated withdrawels wich are much worse.
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Thanks for all your replies.

I think il just stick to the Oxycontin, Diazepam, Diphenydramine, Weed combination, and maybe 1 small bottle of 7.3% Cider - NOT RECOMMENDED TO ANYBODY WHO DOES NOT HAVE A HIGH OPIATE + BENZO TOLERANCE Even for people who do have a tolerance this can be extremely dangerous. (9 times out of 10 i stear clear of any alcohol when using Benzos + Opiates)

@ weekday warrior - I live in the UK, we only have OC formula Oxycontin over here, OP Oxycontin is unheard of. :D
 
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