Opioids (Oxycodone) My views on the best ROA for, are they correct?

[Whosajiggawaaa]

For me I find oral oxycodone to be best, and I've tried snorting (thousands of pills) and have smoked it a fair amount too, to be extravagant kinda.

My view is the popular view by mods in this section that oral oxycodone is the best ROA, and that IVing (and the risks of IVing pills) doesn't justify the 10% increase in bioavailability.
Also that IVing is also not worth it because there is no rush merely a quicker onset.

Is this view objectively speaking correct ?

I've seen a few recent threads where posters say that IVing is worth it (much better than snorting and taking it orally) and there is a rush and that injecting is infact the best ROA.

So I wanted to put the best Oxy ROA to bed (in my mind at least - hopefully a few others).

Ultimately I want to know if I'd be able to do less pills (long term) shooting em. ATM my understanding is no, as IVing would make my tolerance faster than popping oxy orally.

 

[TheLostBoys]

I don't like oxy much, but when the old style oxycontin was around, I actually liked chewing on a half, the high was fast & strong. I never used a needle so I can't comment on that method.

I have snorted, & I prefer oral way more.

I wish Opana had the BA from oral that oxy has......then again, maybe its better it doesn't, because the snorting keeps me far away from Opana. Nothing like having a stuffed up nose 24/7 for a few weeks, hate it with a passion, while others never get a stuffy nose.

 

[Screaming_Skull]

Well, this thread is just gonna turn into an arguement of whats best,lol. Definatley not smoking that waste too much.. Eating is really the best, but if I have some I can shoot, I'm gonna shoot it.. for me, it does have a rush, although it's not as good as dillies or morphine which is what I have to compare it to rush wise....only downside is this cuts down how long the high last of course, so that sucks. With oral it definaltey does last longer, I mean if I had 12 percocets I would basically get the same high as shooting, except without the rush of shooting, but it last longer. It does have a rush, for me anyway. I'm rambling, my favorite is to shoot but I have no problem just eating it either.

Edit: Oh and snorting is nice also, comes on faster which is nice, but still doesn't last as long as eating. I can't help it though if it's a fourm of oxy I can snort, I'm gonna snort it(if I can't bang cuz other people are around), I know the bioavialbity is lower, but I guese it's because that's how I started doing them and enjoy the quicker onset..but still love oral oxy cuz it last longer...I really want some right now after writing this,lol. It's been so fucking dry where Im at, I had 4 people I could go to(two for 15's, two for 30's)the doctor left so, ugh. Need to stay away anyway since I'm trying to do ok on my sub.

 

[pinpoint]

If my stomach is empty then 100% definitely oral, but otherwise it's going up the nose. This is all assuming you don't IV - which would be the best & naturally most dangerous way to consume it.

 

[sekio]

Oral oxycodone has basically the same BA as IV. The slightly decreased absorbtion is offset by the slightly increased first pass metabolism to e.g. oxymorphone.

Rectal (plugging) usage of oxycodone in a little water is another acceptable route, it too has high BA but a faster onset than oral.

Generally the larger the changes in concentrations of the drug (e.g. bigger peaks and valleys in dosing) the more rapidly you'll develop tolerance, so IV oxycodone is probably counterproductive if you want to conserve pills.

 

[atreyaferret]

I'm gonna have to agree with pinpoint on this one.

 

[Whosajiggawaaa]

The empty stomach when dosing that helps a fuckload in terms of intensity, but is usually only possible in the morning before breakfast, maybe I should commit and starve more for the high lol.

So yeah tolerance was one of my main considerations at it seems Iving would increase that, I don't need that. My strategy now is to frequently wait until feeling withdrawal symptoms to dose, in other words increasing the intervals between doses, seems to maximise it for me, helps with the buzz and dose economy.

Clearly it just doesn't seem to be justifiable to pick up the needle for the first time with oxycodone when that oral high, esp when experienced strongly(empty stomach) is already so great.

 

[Psychonauticunt]

If my stomach is empty then 100% definitely oral, but otherwise it's going up the nose. This is all assuming you don't IV - which would be the best & naturally most dangerous way to consume it.

Why?

http://www.ncbi.nlm.nih.gov/pubmed/8901078

For the IR solution, both oxycodone bioavailability and peak plasma oxycodone concentration were significantly altered by consumption of the high-fat meal, with the mean value for AUC0-infinity increasing to 120% (CI = 109-132%) and the mean value for Cmax decreasing to 82% (CI = 47-91%) of values observed in the fasted condition.

That is to say: immediate-release oral oxycodone has increased bioavailability and reduced Cmax (time to reach maximum concentration).

In my experience, shooting oxy is a waste. There's stuff like talcum in the pills you don't want to bang (unless you have Oxanest solution, in which case, go nuts), and there is no rush, at least comparable in any way to morphine or heroin - it's pretty tame. Oral BA when crushed after a fat-heavy meal is very high.

Snorted BA is much lower, and the "rush" is more like "accelerated onset". IV has 100% BA obviously, and rectal is close, but for me the "rush" from IV or relatively fast onset from plugging are not worth getting into. Oral BA is the great thing about oxycodone.

Oral is also the best way to maintain a lower tolerance. Oxy is one of the few stronger opioids where oral is the way to go.

 

[pinpoint]

Why?

OP asked for 'views' so just stating my subjective experience mate, no need to get all technical on me good info though.

 

[Psychonauticunt]

OP asked for 'views' so just stating my subjective experience mate, no need to get all technical on me good info though.

Wasn't trying to "get all technical" - although in a sense, that's exactly what I meant to do, but in a positive, constructive sense. All I'm saying is, try it once on a fat-full stomach for comparison's sake.