I recently came into possession of 30mg of oxycodone (specifically Roxicodone) and while checking into the possible side-effects, interactions, etc. I came across two interactions between this and other medications that I take regularly. Not being very experienced with opiates, especially of the pharmaceutical variety, I wanted to get an opinion on the risks associated with combining these substances.
First off is generic Alprazolam, in extended release tablets. I normally take one milligram each day, not enough that I feel any physical or psychological addiction to take note of, so I could certainly skip taking it for a day if it proves to be too much of a risk. I know opiates and benzodiazepines combined possess the danger of excessive central nervous system depressing effects, but since I take a relatively low dose and most likely have a significant tolerance to the Alprazolam, and will not be dosing more than 15mg of the oxycodone for a first time experience with the substance, I was wondering if this presented a significant risk. I know well about the dangers of mixing these two substances, but most poor or dangerous experiences seem to come from taking fairly high doses of at least one, if not both, so will the 1mg of extended release benzo present much of a risk?
My second question and interaction is the more pertinent one. I also take Ziprasidone 120mg each day, and found it to have similar CNS-depressing dangers as the other interaction. However, after a thorough search through google and bluelight, I couldn't find any information on the severity of this interaction, just the fact that there is one. I feel more worried about this possible interaction, because while 120mg is a typical activated dose for this drug, it is certainly more potent, or at least a much greater milligram content than the Alprazolam. Additionally, I'm a bit concerned about this possible interaction just because of the complete lack of information on how dangerous it might be, or on the interaction at all. Benzos and opiates are a well known risky combo, but is there significant risk between the opiate and atypical anti-psychotic?
Finally, I will most likely be adding in some amount of an amphetamine salt mixture, specifically dextroamphetamine and amphetamine. All the information I've found and heard on this final combination is that it poses none of the risks of the typical speedball of opiates and cocaine, and that in fact the two drugs do not interact at all, or have no significant risks associated with combining them. Is this combination truly as safe as I've heard it is?
-Finally, finally, a two part addendum to my post. First, please save me the typical "If you are prescribed an anti-psychotic you shouldn't be doing drugs at all" post. Although I'm a new poster, I am very experienced with every typical substance as well as a laundry list of RCs and their effects on my mental state, and I take the medication for its mood balancing effects, not its anti-psychotic effects. I'm neurotic, not psychotic, and I know what I can and can't handle right now.
Also I'm a bit new here, pretty much first time poster, and I wasn't sure if this would be considered basic or advanced, so I put it here in Basic to be safe rather than deleted/publicly humiliated or whatever the tradition is here, so feel free to move this wherever it may be best suited to. Overall I'm interested in the interactions between pharmaceutical opiates and this atypical anti-psychotic, since as I said, there doesn't seem to be much if any information on the interaction. I just want a proper risk assessment on the overall situation, since risks do seem to be present. Thanks, and I appreciate the help for a pretty green poster.
First off is generic Alprazolam, in extended release tablets. I normally take one milligram each day, not enough that I feel any physical or psychological addiction to take note of, so I could certainly skip taking it for a day if it proves to be too much of a risk. I know opiates and benzodiazepines combined possess the danger of excessive central nervous system depressing effects, but since I take a relatively low dose and most likely have a significant tolerance to the Alprazolam, and will not be dosing more than 15mg of the oxycodone for a first time experience with the substance, I was wondering if this presented a significant risk. I know well about the dangers of mixing these two substances, but most poor or dangerous experiences seem to come from taking fairly high doses of at least one, if not both, so will the 1mg of extended release benzo present much of a risk?
My second question and interaction is the more pertinent one. I also take Ziprasidone 120mg each day, and found it to have similar CNS-depressing dangers as the other interaction. However, after a thorough search through google and bluelight, I couldn't find any information on the severity of this interaction, just the fact that there is one. I feel more worried about this possible interaction, because while 120mg is a typical activated dose for this drug, it is certainly more potent, or at least a much greater milligram content than the Alprazolam. Additionally, I'm a bit concerned about this possible interaction just because of the complete lack of information on how dangerous it might be, or on the interaction at all. Benzos and opiates are a well known risky combo, but is there significant risk between the opiate and atypical anti-psychotic?
Finally, I will most likely be adding in some amount of an amphetamine salt mixture, specifically dextroamphetamine and amphetamine. All the information I've found and heard on this final combination is that it poses none of the risks of the typical speedball of opiates and cocaine, and that in fact the two drugs do not interact at all, or have no significant risks associated with combining them. Is this combination truly as safe as I've heard it is?
-Finally, finally, a two part addendum to my post. First, please save me the typical "If you are prescribed an anti-psychotic you shouldn't be doing drugs at all" post. Although I'm a new poster, I am very experienced with every typical substance as well as a laundry list of RCs and their effects on my mental state, and I take the medication for its mood balancing effects, not its anti-psychotic effects. I'm neurotic, not psychotic, and I know what I can and can't handle right now.
Also I'm a bit new here, pretty much first time poster, and I wasn't sure if this would be considered basic or advanced, so I put it here in Basic to be safe rather than deleted/publicly humiliated or whatever the tradition is here, so feel free to move this wherever it may be best suited to. Overall I'm interested in the interactions between pharmaceutical opiates and this atypical anti-psychotic, since as I said, there doesn't seem to be much if any information on the interaction. I just want a proper risk assessment on the overall situation, since risks do seem to be present. Thanks, and I appreciate the help for a pretty green poster.
