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Opioids Oxycodone enhancement advice

For sure. I know too well how tempting that combo can be and also how dangerous and life changing/ending. We’re all here to try to make better choices, to get helpful info, and to kind of have a community where we care about the deaths of each other. Knowing you’re still here gives me a lot of joy. I’m stoked to wake up to this message from you. Cheers
 
skipjames said:
Nice! I had a great time back home when people were coming back from their expeditions to Spain , collecting opium in the Bayer´s plantations :) I wonder if it s still a thing. If I ll ever have access to the thing again I ld like to smoke it properly though, eating it led to a MASSIVE constipation...
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Yeah I live in Spain and people go to poppy fields and have big amounts of good opium. Ive been there 2 times 20 years ago and had 100gr of opium. Thats how started my opium adiction. When I finished the opium I began with H.
 
Well, If you really want to get higher take Oxycodone with a stimulant. Such as Cocaine, Meth or some other euphoriating stimulant. It's called a "Speed Ball".
 
Dextro .45 said:
Diclazepam when taken with Oxycodone causes a significant increase in the active metabolite Oxymorphone (Opana) which is also POTENT AS F@CK

Diclazepam (2-Chloro-Diazepam) was synthesized by same chemist who made Diazepam (Valium) & Clonazepam (Klonopin). Diclazepam has 3 active metabolites and are all registered benzodiazepines currently on the market

Diclazepam > Delorazepam >> Lorazepam (Ativan)
longer half life than Valium and Lorazepam still detected after 7-9days after 1mg of parent compound Diclazepam

so if you’re lucky to have access to Diclazepam be cautious as this will turn your Oxycodone into Oxymorphone (Opana).
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Do you have any sources to back this claim up?
 
Caffeine
Agmatine
Turmeric & black pepper
Polygala
Corydalis (may reduce euphoria in high doses due to d2 antagonism)
Codeine is supposed to upregulate cyp2d6 (ie: more oxymorphone)
Antihistamines
Low dose dxm
Blackseed oil
Pregabalin or gabapentin (take gabapentin much later than the opioid as it can decrease absorption significantly
Ephedrine or pseudoephedrine
Be very careful with gabaergics like alcohol, benzos, and barbs as well as GHB, muscle relaxants, and z drugs
However gabaergic herbs are pretty safe to use with it
Scullcap
Valerian & Hops ( mild opioid effect when paired)
Vervain
Chamomile
Licorice
Lemon balm
Passionflower
Chaste berry
Kava
Kanna might add to euphoria mildly
As others have said, tobacco. It will increase endorphins (alcohol does aswell but is much less reasonable to mix with opioids)

DLPA increases enkalphins affinity to mu receptors, great potentiator
Myrrh is a mild kappa agonist
Edit: amphetamines or cathinones (aren't these a subtype of amphetamines?)
 
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MantisGod said:
Hi hi hi there my little droogies! I recently scored some OC 80s! Expensive little guys! If anyone has advice on how to make these suckers go farther and hit harder I would really appreciate it! For context I have no tolerance and plan on taking them orally, split up, etc.
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If I add 150mg of pregabalin to an opiate it multiples it by 2-3x,I’m actually on it today
 
TheLightBringer said:
Do you have any sources to back this claim up?
Click to expand...

It’s from a medical journal online. Just google Diclazepam interaction with Oxycodone metabolism increases Oxymorphone levels …can’t be that hard to find.

I managed to secure pharmaceutical grade Diclazepam 1,000mg around ….and now available in Canada is Avizafone (Pro-Diazepam) which is a very water soluble pro-drug of Valium. Intended for IM administration, very rapid acting 5-10min apparently from a pharmaceutical company marketing Avizafone to the medical community for rapid sedation of violent & aggressive patients, as hospital staff are sometime physically assaulted.

IM Valium or Midazolam are the preferred benzodiazepine IM takes 30-45min for onset. Waaaay too long. Even 5-10min would feel long….restraining a large male with psychosis from Methamphetamine & stimulant abuse/OD, a massive IM dose of Ketamine HCL would be my choice.

Avizafone (Pro-Diazepam) 20mg administered IM injection or Orally is very rapid acting and metabolizes into 100% pure Valium. Not a controlled substance and I can order 100-500 grams if I wanted. Which is very vexing due to a lack of funds ….fck. lol.

I never regard anecdotal here say …I’ll confirm with several different trusted sources, and mostly published medical journals with controlled professional experiments
 
daturetard said:
Caffeine
Agmatine
Turmeric & black pepper
Polygala
Corydalis (may reduce euphoria in high doses due to d2 antagonism)
Codeine is supposed to unregulate cyp2d6 (ie: more oxymorphone)
Antihistamines
Low dose dxm
Blackseed oil
Pregabalin or gabapentin (take gabapentin much later than the opioid as it can decrease absorption significantly
Ephedrine or pseudoephedrine
Be very careful with gabaergics like alcohol, benzos, and barbs as well as GHB, muscle relaxants, and z drugs
However gabaergic herbs are pretty safe to use with it
Scullcap
Valerian & Hops ( mild opioid effect when paired)
Vervain
Chamomile
Licorice
Lemon balm
Passionflower
Chaste berry
Kava
Kanna might add to euphoria mildly
As others have said, tobacco. It will increase endorphins (alcohol does aswell but is much less reasonable to mix with opioids)

DLPA increases enkalphins affinity to mu receptors, great potentiator
Myrrh is a mild kappa agonist
Edit: amphetamines or cathinones (aren't these a subtype of amphetamines?)
Click to expand...
Ive read in here that you must take pregabalin before an opioid. Why do you say that you have to take it after the opioid?
 
Dextro .45 said:
It’s from a medical journal online. Just google Diclazepam interaction with Oxycodone metabolism increases Oxymorphone levels …can’t be that hard to find.
Click to expand...
Found it 🫡

”In mice, in acute conditions, both diazepam and diclazepam inhibited the metabolism of oxycodone. In chronic conditions and at pharmacologically equivalent doses, diclazepam drastically enhanced the production of oxymorphone. In silico, the affinity of benzodiazepines was higher than oxycodone for CYP3A4, inhibiting oxycodone metabolism through CYP3A4. Oxycodone metabolism is likely to be diverted towards CYP2D6.

Conclusion and implications: Acute doses of diazepam or diclazepam result in the accumulation of oxycodone, whereas chronic administration induces the accumulation of oxymorphone, the toxic metabolite.”

pubmed.ncbi.nlm.nih.gov

Metabolic interactions of benzodiazepines with oxycodone ex vivo and toxicity depending on usage patterns in an animal model - PubMed

This article is part of a themed issue on Advances in Opioid Pharmacology at the Time of the Opioid Epidemic. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v180.7/issuetoc.
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Seems like chronic use of diclazepam resulted in more oxymorphone in mice. Surely other benzos with a high affinity for CYP3A4 should have similar results on oxycodones metabolism 🤔🤔
 
Yep....DDI's ...ain't they a bitch lol ....or in some cases, a very desirable science experiment inside your liver

Drug & Drug Interactions can be fatal, very dangerous...can lead to a "hyper tensive crisis" leading to stoke & heart attack, serotonin syndrome, or psychosis.

Intentional DDI's are to enhance the euphoric or desirable subjective effects of a drug.

Perfect example I do daily....taking Ritalin (Methylphenidate) with Ethanol/alcohol increases levels of d-threo-Methylphenidate (Focalin) by 40% significantly enhancing the euphoric & pleasurable subjective effects of Ritalin in all study participants. Also, taking Ritalin with a fatty meal (toasted egg & bacon/ham sandwich) speeds and enhances absorption (increased c-max)

First pass metabolism......fckn A.

Dilaudid (Hydromorphone) taken orally only has a bioavailability of 30% .....nearly 70% of the oral dose is destroyed by the liver ....why Dilaudid is the most highly abused narcotic via IV injection

7.5mg orally
1.5mg IV injection

Hydromorphone administered IV/IM/SC is a POTENT opioid indeed when injected.

Diazepam (Valium) and Alprazolam (Xanax) would be the two most highly desirable benzodiazepines

Oxycodone without question is the most euphoric and pleasurable opioid. A non-sedating, mildly stimulating, VERY effective & potent opioid narcotic analgesic

Oral Oxycodone & Ritalin (Methylphenidate) were the only two drugs to ever give me True Euphoria. An overwhelmingly pleasurable & happy dopaminergic stimulant and opioid. Like a thousand Christmas mornings in a single Oxy 80
 
Dextro .45 said:
Oral Oxycodone & Ritalin (Methylphenidate) were the only two drugs to ever give me True Euphoria. An overwhelmingly pleasurable & happy dopaminergic stimulant and opioid. Like a thousand Christmas mornings in a single Oxy 80
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Im curious as to which drugs you have tried, ive always been a bit fascinated at how subjective perceptions on which drugs are the most euphoric can vary so wildly from user to user.

Ive met people who hate stims and say that benzos and alc give them the most ”pleasure” and others that say opiates suck without euphoria and they can only enjoy stims etc etc.

Personally when I was using I loved every class of drug and enjoyed everything. Im curious what stims you have tried though, objectively most people would agree that amphetamine is far more euphoric than methylphenidate and I myself stopped getting any euphoria from MPH once I had a decent stim tolerance. But I have a friend who loved MPH over every other stimulant strangely enough
 
Dextro .45 said:
It’s from a medical journal online. Just google Diclazepam interaction with Oxycodone metabolism increases Oxymorphone levels …can’t be that hard to find.

I managed to secure pharmaceutical grade Diclazepam 1,000mg around ….and now available in Canada is Avizafone (Pro-Diazepam) which is a very water soluble pro-drug of Valium. Intended for IM administration, very rapid acting 5-10min apparently from a pharmaceutical company marketing Avizafone to the medical community for rapid sedation of violent & aggressive patients, as hospital staff are sometime physically assaulted.

IM Valium or Midazolam are the preferred benzodiazepine IM takes 30-45min for onset. Waaaay too long. Even 5-10min would feel long….restraining a large male with psychosis from Methamphetamine & stimulant abuse/OD, a massive IM dose of Ketamine HCL would be my choice.

Avizafone (Pro-Diazepam) 20mg administered IM injection or Orally is very rapid acting and metabolizes into 100% pure Valium. Not a controlled substance and I can order 100-500 grams if I wanted. Which is very vexing due to a lack of funds ….fck. lol.

I never regard anecdotal here say …I’ll confirm with several different trusted sources, and mostly published medical journals with controlled professional experiments
Click to expand...
Yeah pretty sure diclazepam upregulates (not sure of that's the right term) cyp2d6 meaning it metabolizes faster. It could be the new glutethimide (doriden) when combined with codeine as they are both gabaergic substances that increase the efficiency of cyp2d6. Dors and 4 is something I've always wanted to try but seeing as I'll never get to, this may be the way to go.
 
TheLightBringer said:
Im curious as to which drugs you have tried, ive always been a bit fascinated at how subjective perceptions on which drugs are the most euphoric can vary so wildly from user to user.

Ive met people who hate stims and say that benzos and alc give them the most ”pleasure” and others that say opiates suck without euphoria and they can only enjoy stims etc etc.

Personally when I was using I loved every class of drug and enjoyed everything. Im curious what stims you have tried though, objectively most people would agree that amphetamine is far more euphoric than methylphenidate and I myself stopped getting any euphoria from MPH once I had a decent stim tolerance. But I have a friend who loved MPH over every other stimulant strangely enough
Click to expand...

I’ve done every drug on earth probably. Within reason.

Chemical make-up & purity of non regulated illicit substances are another thing….like I’ve done MDMA several times….one time light drown crystals were amazing lovey dovey euphoria, another one was a pressed tablet and was more trippy and visual.

Ive IV administered Ketamine, Cocaine, Heroin, Dilaudid, OxyContin, depo-Testosterone IM
Orally Ritalin, Adderall, Vyvanse, Dexedrine, Oxy-IR, Dilaudid, Pregabalin, Valium, Ativan, Klonopin, Xanax, RC chems, LSD, Psilocybin mushrooms, Cannabis, etc, etc

My daily routine is my Hybrid Brompton Cocktail 🍸

Methadone 100-125mg
Ritalin (Methylphenidate) 50-70mg
Valium (Diazepam) 20-30mg
Xanax (Alprazolam) 1mg
Lyrica (Pregabalin) 300-450mg
Ethanol (Gin) 2.oz X 4-6 drinks over 4 hours or so

Weekend Saturday is LSD 100ug usually

No crack or Meth

Nothing has ever came close to euphoric happiness oral Oxycodone gave me ….about 7 years later oral Ritalin (Methylphenidate) game me nearly identical inner happiness and pleasure. Those two compounds together and Fck me silly lol.
 
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