Opioids Oxycodone + Amobarbital v.s. Oxycodone + Soma and/or Benzos

[muie]

I've treid to get an answer to this for a long time but to no avail so here it is again, I have a massive benzo tolerence so that i've been on 4-5mg clonazepam a day since 04 basically meaning I always take opioids with benozs. My opiate tolerence is not that high at the moment but still high enough to piss me off (60mg-120mg codeine to be good though I can take up to 100mg methadone or 80mg oxy).

I was impressed with benzos and opiates at first (I had a g/day dope habit, or 10mg smoked duragesic fentanyl, 30+ snorted hydromorphine (to keep w/ds at bay) then I got on 205mg methadone for about 2 1/hyrs.

My favorite combo now after all the tolerence is Soma and opioids.

I have the rare opportunity to try amobarbital and I've tried it before with codeine but didn't notice much although the most i've taken was 50mg. I've taken quite a bit of amobarbital most being 250mg along with a shot or two of rum. I'm used to taking 100mg-125mg for relaxation although I can feel as little as 50mg-75mg. My experience with barbies goes to butabital, phenobarbital, benzobarbital and amobarbital (by far the best).

The theory is that oxycodone needs to be converted into active metabolites and barbies inhibit the cyp 2d6 enzyme which is responsible for turning codeine to morphine, soma to meprobamate (cyp 2c19), and apparently oxycodone into oxymorphone. In any case the theories are conflicting saying that since both compete for the same enzyme there is actually less of an opioid effect. On the other hand they market formulations like butabital/codeine, even phenobarbital/codeine so I'm not sure what to beleive.

p.s. I know this is not dangerous as I've mixed amobarbial before with opioids (like codeine, oxy, methadone) so it's not a dice game if used responsibly, please let me know the answer to this

 

[sekio]

most of oxycodone's activity comes from the codone itself, not metabolic side products

 

[muie]

Oxycodone (OxyContin® and others) is similar in structure to hydrocodone, with the addition of a hydroxyl (–OH) group at the 14-carbon. Unlike codeine and hydrocodone, oxycodone is a potent analgesic in its own right. Therefore, oxycodone is not a prodrug. There is an active metabolite, however, as 2D6 activity creates oxymorphone (Numorphan®), an active opioid analgesic. This 3A4 activity appears to create inactive noroxycodone. When a 2D6 inhibitor was given with oxycodone in 10 volunteers, the amount of the 2D6 metabolite, oxymorphone, essentially disappeared, but the subjective feeling of being "on" oxycodone did not change. Unfortunately, pain was not measured in this study.

Since it appears that 2D6 is major pathway for oxycodone's clearance, some have been concerned that toxicity could occur with oxycodone in patients with genetically poor 2D6 metabolism or in the constant presence of a 2D6 inhibitor, such as fluoxetine or paroxetine. Indeed, in one postmortem retrospective analysis of 15 deaths where suspected oxycodone toxicity was a cause of death, there were two, and possibly six, deaths that occurred in patients with poor 2D6 metabolism, and four of these cases helped better interpret the oxycodone toxicity. In another retrospective study involving nine deaths associated with oxycodone, the amount of oxycodone in the blood was higher than expected when used therapeutically. Four of the cases involved no other centrally acting drug (i.e., alcohol, benzodiazepine, stimulant, etc.). Although genetic testing was not done, in retrospect we wonder if some of these individuals either had poor 2D6 metabolism or ingested an inhibitor of 2D6 that contributed to their high oxycodone levels. The review unfortunately did not consider pharmacogenetics.

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