You could, just take the needle off of course, don't shove a needle up your asshole, you will regret it...do you have one of those syringes used for giving medicine you just get at the store? Those are best for plugging, make sure your ass is clear of poop, may gross ya out but just stick your finger in up there to be really sure...How much are you banging, it only last 45 mins???? It is a shorter high when injected but usually a few hours... Really just eat them, or snort them. You get the most outta eating them on an empty stomach, it last the longest, and its the easiest. These were the first ones I ever tried banging by myself before I had others do it....but just make sure your butts clear and the needle is off and your good to plug, it will come on quicker, but not sure if it last longer than just eating....