Oxidative Stress

[saturatedlies]

Is supposedly what occurs in the brain after ingesting a neurotoxic amount of MDMA. Anyone know anything about it?

 

[bhamster]

I've read of this (Reactive Oxygen Species) in relation to alcohol abuse (being a cause for liver damage), but can't find any formal studies relating to MDMA. Can you provide a link to a medical journal or published study?

 

[F1n1shed]

It doesn't even have to be a neurotoxic dose of MDMA. Rather an effective dose of MDMA, once MDMA runs its course your body breaks it down into toxic metabolites. Some studies say dopamine gets picked up in the serotonin receptors. Most say oxidative stress occurs on the serotonin axon terminals and can cleave and destroy some of them, which may or may not come back.

 

[saturatedlies]

I've read of this (Reactive Oxygen Species) in relation to alcohol abuse (being a cause for liver damage), but can't find any formal studies relating to MDMA. Can you provide a link to a medical journal or published study?

http://www.erowid.org/chemicals/mdma/mdma_article3.shtml

http://www.ncbi.nlm.nih.gov/pubmed/12797468

http://www.mdma.net/toxicity/oxidative-stress.htm

http://www.mdma.net/toxicity/oxidativestress.html

http://www.mdma.net/misc/oxidative-stress.html