JessFR
Bluelight Crew
There's a lot things in life where you can reasonably be allowed not to give a shit.
Diseases you can catch and then give to other people probably aren't one of them though.
At least one maybe even two shits might be warranted.
Covid-19 Outbreak of new SARS-like coronavirus (Covid-19)
- Thread starter S.J.B.
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There's a lot things in life where you can reasonably be allowed not to give a shit.
Diseases you can catch and then give to other people probably aren't one of them though.
At least one maybe even two shits might be warranted.
jpgrdnr
Bluelighter
Well, I still have to wear a mask in order to buy cookies.
Its more about what's in front of my face as opposed to something on the Internet.
Its more about what's in front of my face as opposed to something on the Internet.
alasdair
birdup.snaildown
Greenlighter
People in certain poor countries have been dying so rapidly from the virus that they are struggling to afford to bury all of them individually and they have been constructing mass graves.
I don't believe this is happening in the US, if that's what you mean by nationwide... but I could be wrong?
I don't believe this is happening in the US, if that's what you mean by nationwide... but I could be wrong?
birdup.snaildown
Greenlighter
I find it extraordinary that some people on this forum actually argue against COVID having a high death toll when the mass grave situation exists in a place as affluent as New York state.
jpgrdnr
Bluelighter
Mass graves are more for people who don't have the money for a burial. And given the history of Hart Island and pandemics it seems fairly typical.
en.wikipedia.org
Interesting side note in that early on in the AIDS epidemic in NYC, the indigent were buried there because they didn't know if bodies carried HIV or not.
Hart Island (Bronx) - Wikipedia
Interesting side note in that early on in the AIDS epidemic in NYC, the indigent were buried there because they didn't know if bodies carried HIV or not.
Deru
Bluelight Crew
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The FDA's first analysis of the data for Pfizer's vaccine.
The Food and Drug Administration’s first analysis of the clinical trial data also found that the coronavirus vaccine worked well regardless of a volunteer’s race, weight or age.
A nurse at the Royal Free Hospital in London simulating the administration of Pfizer’s vaccine during a training session last week.Credit...Pool photo by Yui Mok
By Noah Weiland and Carl Zimmer
The finding is one of several significant new results featured in the briefing materials, which include more than 100 pages of data analyses from the agency and from Pfizer. Last month, Pfizer and BioNTech announced that their two-dose vaccine had an efficacy rate of 95 percent after two doses administered three weeks apart. The new analyses show that the protection starts kicking in far earlier.
What’s more, the vaccine worked well regardless of a volunteer’s race, weight or age. While the trial did not find any serious adverse events caused by the vaccine, many participants did experience aches, fevers and other side effects.
“This is what an A+ report card looks like for a vaccine,” said Akiko Iwasaki, an immunologist at Yale University.
On Thursday, F.D.A.’s vaccine advisory panel will discuss these materials in advance of a vote on whether to recommend authorization of Pfizer and BioNTech’s vaccine.
Pfizer and BioNTech began a large-scale clinical trial in July, recruiting 44,000 people in the United States, Brazil and Argentina. Half of the volunteers got the vaccine, and half got the placebo.
New coronavirus cases quickly tapered off in the vaccinated group of volunteers about 10 days after the first dose, according to one graph in the briefing materials. In the placebo group, cases kept steadily increasing.
Despite the early protection afforded by the first dose, it’s unclear how long that protection would last on its own, underscoring the importance of the second dose. Previous studies have found that the second dose of the Pfizer-BioNTech vaccine gives the immune system a major, long-term boost, an effect seen in many other vaccines.
The efficacy of the vaccine after the first dose is about 52 percent, according to Dr. William C. Gruber, senior vice president of Pfizer Vaccine Clinical Research and Development. After the second dose, that rises to about 95 percent. “Two doses of vaccine provide maximum protection,” he said.
Many experts have expressed concern that the coronavirus vaccines might protect some people better than others. But the results in the briefing materials indicate no such problem. The vaccine has a high efficacy rate in both men and women, as well as similar rates in white, Black and Latino people. It also worked well in obese people, who carry a greater risk of getting sick with Covid-19.
Some vaccines for other diseases set off a weak immune response in older adults. But Pfizer and BioNTech found that people over 65 got about as much protection from the coronavirus vaccine as younger people did.
Even if the vaccine is authorized by the F.D.A., the trial will continue. In the briefing documents, the companies said that they would encourage people to stay in the trial as long as possible, not knowing whether they got the vaccine or the placebo, so that the researchers could continue to collect information about whether the vaccine was safe and effective.
The briefing materials also provide a deeper look at the safety of the vaccine. In any large clinical trial, some people who get vaccines experience health conditions that have nothing to do with the vaccine itself. Comparing their rates of symptoms with those of the placebo group as well as with background rates in a population can point to symptoms that may actually be caused by a vaccine.
The F.D.A. concluded that there were no “meaningful imbalances” in serious health complications, known as adverse events, between the two groups. The agency noted that four people in the vaccinated group experienced a form of facial paralysis called Bell’s palsy, with no cases in the placebo group. The difference between the two groups wasn’t meaningful, and the rate in the vaccinated group was not significantly higher than in the general population.
The new Pfizer analysis revealed that many volunteers who received the vaccine felt ill in the hours after the second dose, suggesting that many people might have to request a day off work or be prepared to rest until the symptoms subside. Among those between ages 16 and 55, more than half developed fatigue, and more than half also reported headaches. Just over one-third felt chills, and 37 percent felt muscle pain. About half of those over age 55 felt fatigued, one-third developed a headache and about one-quarter felt chills, while 29 percent experienced muscle pain.
“Taking a day off after the second dose is a good thing to anticipate,” Dr. Iwasaki said.
On Monday, Kristen Choi, a psychiatric nurse and health services researcher at the University of California, Los Angeles, published a first-person account of the symptoms she experienced as a participant in the Pfizer-BioNTech trial, which included chills, nausea, headache and fever.
“Clinicians will need to be prepared to discuss with patients why they should trust the vaccine and that its adverse effects could look a lot like Covid-19,” Dr. Choi wrote in the journal JAMA Internal Medicine. She advised doctors to tell patients that these unpleasant symptoms were “a sign that the vaccine is working, despite the unfortunate similarities with the disease’s symptoms.”
Pfizer’s Vaccine Offers Strong Protection After First Dose
Pfizer’s Vaccine Offers Strong Protection After First Dose
The Food and Drug Administration’s first analysis of the clinical trial data also found that the coronavirus vaccine worked well regardless of a volunteer’s race, weight or age.
A nurse at the Royal Free Hospital in London simulating the administration of Pfizer’s vaccine during a training session last week.Credit...Pool photo by Yui Mok
By Noah Weiland and Carl Zimmer
- Dec. 8, 2020Updated 9:29 a.m. ET
The finding is one of several significant new results featured in the briefing materials, which include more than 100 pages of data analyses from the agency and from Pfizer. Last month, Pfizer and BioNTech announced that their two-dose vaccine had an efficacy rate of 95 percent after two doses administered three weeks apart. The new analyses show that the protection starts kicking in far earlier.
What’s more, the vaccine worked well regardless of a volunteer’s race, weight or age. While the trial did not find any serious adverse events caused by the vaccine, many participants did experience aches, fevers and other side effects.
“This is what an A+ report card looks like for a vaccine,” said Akiko Iwasaki, an immunologist at Yale University.
On Thursday, F.D.A.’s vaccine advisory panel will discuss these materials in advance of a vote on whether to recommend authorization of Pfizer and BioNTech’s vaccine.
Pfizer and BioNTech began a large-scale clinical trial in July, recruiting 44,000 people in the United States, Brazil and Argentina. Half of the volunteers got the vaccine, and half got the placebo.
New coronavirus cases quickly tapered off in the vaccinated group of volunteers about 10 days after the first dose, according to one graph in the briefing materials. In the placebo group, cases kept steadily increasing.
Despite the early protection afforded by the first dose, it’s unclear how long that protection would last on its own, underscoring the importance of the second dose. Previous studies have found that the second dose of the Pfizer-BioNTech vaccine gives the immune system a major, long-term boost, an effect seen in many other vaccines.
The efficacy of the vaccine after the first dose is about 52 percent, according to Dr. William C. Gruber, senior vice president of Pfizer Vaccine Clinical Research and Development. After the second dose, that rises to about 95 percent. “Two doses of vaccine provide maximum protection,” he said.
Many experts have expressed concern that the coronavirus vaccines might protect some people better than others. But the results in the briefing materials indicate no such problem. The vaccine has a high efficacy rate in both men and women, as well as similar rates in white, Black and Latino people. It also worked well in obese people, who carry a greater risk of getting sick with Covid-19.
Some vaccines for other diseases set off a weak immune response in older adults. But Pfizer and BioNTech found that people over 65 got about as much protection from the coronavirus vaccine as younger people did.
How the Pfizer-BioNTech Vaccine Works
Two shots can prime the immune system to fight the coronavirus.Even if the vaccine is authorized by the F.D.A., the trial will continue. In the briefing documents, the companies said that they would encourage people to stay in the trial as long as possible, not knowing whether they got the vaccine or the placebo, so that the researchers could continue to collect information about whether the vaccine was safe and effective.
The Road to a Coronavirus Vaccine
Words to Know About Vaccines
Confused by the all technical terms used to describe how vaccines work and are investigated? Let us help:- Adverse event: A health problem that crops up in volunteers in a clinical trial of a vaccine or a drug. An adverse event isn’t always caused by the treatment tested in the trial.
- Antibody: A protein produced by the immune system that can attach to a pathogen such as the coronavirus and stop it from infecting cells.
- Approval, licensure and emergency use authorization: Drugs, vaccines and medical devices cannot be sold in the United States without gaining approval from the Food and Drug Administration, also known as licensure. After a company submits the results of clinical trials to the F.D.A. for consideration, the agency decides whether the product is safe and effective, a process that generally takes many months. If the country is facing an emergency — like a pandemic — a company may apply instead for an emergency use authorization, which can be granted considerably faster.
- Background rate: How often a health problem, known as an adverse event, arises in the general population. To determine if a vaccine or a drug is safe, researchers compare the rate of adverse events in a trial to the background rate.
- Efficacy: The benefit that a vaccine provides compared to a placebo, as measured in a clinical trial. To test a coronavirus vaccine, for instance, researchers compare how many people in the vaccinated and placebo groups get Covid-19. Effectiveness, by contrast, is the benefit that a vaccine or a drug provides out in the real world. A vaccine's effectiveness may turn out to be lower or higher than its efficacy.
- Phase 1, 2, and 3 trials: Clinical trials typically take place in three stages. Phase 1 trials usually involve a few dozen people and are designed to observe whether a vaccine or drug is safe. Phase 2 trials, involving hundreds of people, allow researchers to try out different doses and gather more measurements about the vaccine’s effects on the immune system. Phase 3 trials, involving thousands or tens of thousands of volunteers, determine the safety and efficacy of the vaccine or drug by waiting to see how many people are protected from the disease it’s designed to fight.
- Placebo: A substance that has no therapeutic effect, often used in a clinical trial. To see if a vaccine can prevent Covid-19, for example, researchers may inject the vaccine into half of their volunteers, while the other half get a placebo of salt water. They can then compare how many people in each group get infected.
- Post-market surveillance: The monitoring that takes place after a vaccine or drug has been approved and is regularly prescribed by doctors. This surveillance typically confirms that the treatment is safe. On rare occasions, it detects side effects in certain groups of people that were missed during clinical trials.
- Preclinical research: Studies that take place before the start of a clinical trial, typically involving experiments where a treatment is tested on cells or in animals.
- Viral vector vaccines: A type of vaccine that uses a harmless virus to chauffeur immune-system-stimulating ingredients into the human body. Viral vectors are used in several experimental Covid-19 vaccines, including those developed by AstraZeneca and Johnson & Johnson. Both of these companies are using a common cold virus called an adenovirus as their vector. The adenovirus carries coronavirus genes.
- Trial protocol: A series of procedures to be carried out during a clinical trial.
The briefing materials also provide a deeper look at the safety of the vaccine. In any large clinical trial, some people who get vaccines experience health conditions that have nothing to do with the vaccine itself. Comparing their rates of symptoms with those of the placebo group as well as with background rates in a population can point to symptoms that may actually be caused by a vaccine.
The F.D.A. concluded that there were no “meaningful imbalances” in serious health complications, known as adverse events, between the two groups. The agency noted that four people in the vaccinated group experienced a form of facial paralysis called Bell’s palsy, with no cases in the placebo group. The difference between the two groups wasn’t meaningful, and the rate in the vaccinated group was not significantly higher than in the general population.
The new Pfizer analysis revealed that many volunteers who received the vaccine felt ill in the hours after the second dose, suggesting that many people might have to request a day off work or be prepared to rest until the symptoms subside. Among those between ages 16 and 55, more than half developed fatigue, and more than half also reported headaches. Just over one-third felt chills, and 37 percent felt muscle pain. About half of those over age 55 felt fatigued, one-third developed a headache and about one-quarter felt chills, while 29 percent experienced muscle pain.
“Taking a day off after the second dose is a good thing to anticipate,” Dr. Iwasaki said.
On Monday, Kristen Choi, a psychiatric nurse and health services researcher at the University of California, Los Angeles, published a first-person account of the symptoms she experienced as a participant in the Pfizer-BioNTech trial, which included chills, nausea, headache and fever.
“Clinicians will need to be prepared to discuss with patients why they should trust the vaccine and that its adverse effects could look a lot like Covid-19,” Dr. Choi wrote in the journal JAMA Internal Medicine. She advised doctors to tell patients that these unpleasant symptoms were “a sign that the vaccine is working, despite the unfortunate similarities with the disease’s symptoms.”
Following the U.K., Canada has just authorized the use of the Pfizer/BioNTech COVID-19 vaccine. The U.S. will surely follow very soon.
F.U.B.A.R.
Bluelight Crew
Just waiting for the anti-vaxers to jump on the news that two NHS staff suffered severe allergic reactions to the vaccine yesterday...
www.telegraph.co.uk
Two NHS workers suffer allergic reaction to Pfizer vaccine
UK regulators have issued a warning that people who have a history of "significant" allergic reactions should not currently receive the Pfizer/BioNTech Covid-19 vaccine after two NHS staff members who had the jab suffered allergic reactions.
Deleted member 521610
Bluelighter
if i get the vaccine in the future and it fucks me up i want a few million payout from pfizer
Here's a thorough briefing document submitted by Pfizer to the FDA in support of their EUA.
JessFR
Bluelight Crew
Yeaaah.
This vaccine hasn't been tested long enough! As it stands if we use it now, potentially dozens, maybe even hundreds of people could experience serious side effects.
Seems clear that we can't use these vaccines until we've spent another year or so testing them. That million or so people dead over that time period is a small price to pay for a slightly safer vaccine! Amirite?
Besides, as a young person I'm unlikely to die. So it only seems fair that a few million older people die to ensure my personal peace of mind.
This vaccine hasn't been tested long enough! As it stands if we use it now, potentially dozens, maybe even hundreds of people could experience serious side effects.
Seems clear that we can't use these vaccines until we've spent another year or so testing them. That million or so people dead over that time period is a small price to pay for a slightly safer vaccine! Amirite?
Besides, as a young person I'm unlikely to die. So it only seems fair that a few million older people die to ensure my personal peace of mind.
No problem!
If you want a good summary of vaccine details as they come out, I would recommend the blog In the Pipeline.
JessFR
Bluelight Crew
Well he doesn't. He doesn't even give a shit about his fanatical supporters.
He gives a shit about himself. Everything else is about supporting that. His supporters included.
He gives a shit about himself. Everything else is about supporting that. His supporters included.
JGrimez
Bluelighter
- Joined
- Jan 23, 2018
- Messages
- 5,495
How's the vaccine going? Couple of people died after taking it in the UK, NHS workers had extreme reactions. Now they're saying anyone with a history of allergic reactions shouldn't take it. The Australian version was binned after it showed HIV "false positives" among people who took it. They're saying don't get pregnant for a couple of months afterwards and they don't know whether or not it makes men or women sterile.
I've said from the beginning that this was leading to a forced vaccination. I've also maintained that this vaccine is a potential death sentence.
Most vaccines take around 10 years on average. The quickest one took 4 years. This one took 8 months and it's a new experimental type of vaccine never before used on humans. Why would you even risk taking it for a virus that has a 99.97% survival rate for most people? Why are they even suggesting to mandate it?
Does anyone on this forum plan to take it?
Also, nobody in the Australian media or government will be talking about this fact:
I've said from the beginning that this was leading to a forced vaccination. I've also maintained that this vaccine is a potential death sentence.
Most vaccines take around 10 years on average. The quickest one took 4 years. This one took 8 months and it's a new experimental type of vaccine never before used on humans. Why would you even risk taking it for a virus that has a 99.97% survival rate for most people? Why are they even suggesting to mandate it?
Does anyone on this forum plan to take it?
Also, nobody in the Australian media or government will be talking about this fact:
JGrimez
Bluelighter
- Joined
- Jan 23, 2018
- Messages
- 5,495
UK Health Secretary Matt Hancock pretending to cry when talking about how wonderful the vaccine roll out is.
Duper's delight is when a liar is secretly extremely pleased that their lie is being believed, and their delight leaks through in the form of barely suppressed smiling
Sports stars and high-value business travellers exempt from UK's quarantine
I didn't realize that this virus is only dangerous for the poor and unprivileged. So sports leagues making tons more money for elites is essential but the average person opening their business in order to feed their family is non-essential. Go figure.
Duper's delight is when a liar is secretly extremely pleased that their lie is being believed, and their delight leaks through in the form of barely suppressed smiling
Sports stars and high-value business travellers exempt from UK's quarantine
I didn't realize that this virus is only dangerous for the poor and unprivileged. So sports leagues making tons more money for elites is essential but the average person opening their business in order to feed their family is non-essential. Go figure.
birdup.snaildown
Greenlighter
JGrimez said:
I have to take it in order to keep my job.
I'm not particularly concerned about it.
The people who died after taking the vaccine died during the clinical trial process. 6 people died total in that trial, 4 of whom had been given a placebo. So, that's not a problem.
The Australian UQ vaccine trial was scrapped before rollout because of the HIV false positive. So, the trial process worked.
Every drug ever made is a "potential death sentence". There is no reason (at this point) to assume that the Pfizer vac is going to kill people.
The NHS workers had anaphylactic (severe allergic) reactions. When you receive the vaccine shot, you are monitored for half an hour afterwards. Anaphylaxis kicks in pretty much instantly, so I'm not concerned about that either since they have epipens ready in case there is an issue.
Until there are actual deaths caused by the vaccine, I'm not going to assume it's deadly... in the same way I'm not going to assume Trump won the election unless there's evidence that he won the election.
JGrimez
Bluelighter
- Joined
- Jan 23, 2018
- Messages
- 5,495
So this virus has a 99.97% recovery rate and even 94.6% among the most elderly.
Do you support mandating the vaccine globally? If not, you shouldn't take it, mass non-compliance is the only way that we can object to a global mandate.
You don't need to answer but what field do you work in?
A friend is a US pilot and he doesn't want to take it but doesn't want to lose his job either. I think it's despicable that they are basically forcing people to take it.
Do you support mandating the vaccine globally? If not, you shouldn't take it, mass non-compliance is the only way that we can object to a global mandate.
You don't need to answer but what field do you work in?
A friend is a US pilot and he doesn't want to take it but doesn't want to lose his job either. I think it's despicable that they are basically forcing people to take it.
birdup.snaildown
Greenlighter
Nobody is talking about mandatory vaccines, let alone worldwide mandatory vaccines. I am a nurse. I work in a hospital.
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