I have read an article on erowid which said that taking 150 mg of diphenhydramine increases the pleasure from orgasms. Does the same thing happen if one takes 300 mg of dramamine? does anyone have personal experience on this matter?
No.... although another's individual's subjective experience may be completely different than mine.
For me, pot, tramadol, or buproprion (wellbutrin/zyban) DID make orgasms more intense & longer lasting.
However, you're probably better off teaching yourself a few of the natural tricks used in the Kama Sutra & Tantra to intensify orgasms. A bit of self-control did more for my orgasms than any substance ever did.
Histamines are needed to orgasm... I find antihistamines somewhat inhibit the onset of orgasm for me, but not really affect the quality. I find I have to go a bit longer to get there, but maybe that's just me.
Niacin flush is a histamine response too, some say taking a high dose of niacin and B5 together 'feeds' an orgasm,,,, but i don't know.