oral bioavailability of amphetamines?

[zorn]

Does anyone know the oral bioavailibities of amphetamine, methamphetamine, and MDMA? I've been vaguely looking for a while, but haven't run across anything.
-Zorn

 

[brand0n]

I'm no doctor but I've never even heard the term "oral bioavailablity" perhaps you could shed some light on the definition??

 

[zorn]

Bioavailability is the portion of a substance that eventually makes it into your bloodstream, where it can do what it's supposed to do. Eg the oral bioavailabilities of codeine/hydrocodone are around 60%.... this much of the substance (taken orally) gets into circulation, the other 40% gets excreted or metabolized before reaching the blood.
-Zorn

 

[djremix]

that is very interesting.
what about adderall? shouldnt that give a good indication with regards to amphetamine / e?
also has anyone ever toyed with the idea of transdermal ecstacy?
pure mdma powder through the skin into the bloodstream.
you know like that new patch the fda just approved as an option other than a normal BC pill?
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If you think life is really good, wait till you hear the REMIX!

 

[brand0n]

I believe in the plugging FAQ they said that 50-60% of an oral dosage of MDMA worms it's way into your body. Since MDMA is a derivative of methamphetamine, I'd imagine that the oral bioavailability of amphetamine and methamphetamine would be similar. Look at me, my last post I was asking what the term "oral bioavailability" meant and now I'm using it like I'm a doctor or something, geesh

 

[zorn]

I'd guess so too, but I was kinda looking for a referenced result. Actually I'm pretty certain amp/meth bioavailibity is above 70%, but I'd like to see a real number. Anyone?
Transdermal MDMA wouldn't work, sorry.

Nice thought though. Patches can only deliver very small amounts of a substance, under a milligram/hour. MDMA isn't potent enough. And you wouldn't really want MDMA in your bloodstream for days, it would lose effectiveness pretty quickly.
-Zorn

 

[zorn]

Around that... the 100ug/hour duragesuc patches contain 10mg of fentanyl.

 

[Icehead]

Would it not be the same as with other ingested drugs/medicines around 40% (I have read somwhere) is actually metabolised by the body, and the rest is filtered by the liver as its supposed to be.
Hence the research into these new 'smart drugs' (no, not designer recreational drugs) which target the actual site/organ by various innovative means.
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Just say know.

 

[Beeebs]

You could in theroy do transdermal MDMA using DMSO, this is definatly NOT recommended due to the effects of DMSO by itself.
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AIM/MSN/Y! - ciajs1

 

[fairnymph]

zorn --
I had a book that had such figures in it, but I lost it ( I need it for class, too).

From what I remember, the oral bioavailability is 80-90% depending on the amphetamine. I will ask my professor in class tomorrow though, and see if he has any idea...
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You can be rich and still be a fucking moron loser who smokes crack all the time. -- Kyk

 

[Drug Dustbin]

Zorn, the oral bioavailability of methamphetamine is about 70%. I haven't found any data for other amphetamines
Cook CE, Jeffcoat AR, Sadler BM, Hill JM, Voyksner RD, Pugh DE, White WR, Perez-Reyes M.
Pharmacokinetics of oral methamphetamine and effects of repeated daily dosing in
humans. Drug Metab Dispos. 1992 Nov-Dec;20(6):856-62.
Cook CE, Jeffcoat AR, Hill JM, Pugh DE, Patetta PK, Sadler BM, White WR,Perez-Reyes M.
Pharmacokinetics of methamphetamine self-administered to human subjects by
smoking S-(+)-methamphetamine hydrochloride. Drug Metab Dispos. 1993;21(4):717-23.

 

[zorn]

Thanks!

 

[Diffidence]

http://www.twilightbridge.com/psychiatryproper/drugbulletin/methylphenidate/pharmacology.htm
This lists the oral bioavailability of Methylphenidate as approximately 30% with large individual differences (11 to 52%). Obviously still not the amphetamine answer we're looking for. I found these exact numbers quoted at a couple of other places across the web but didn't notice a source.