Hi all I have a quick question about potentiators such as white grapefruit juice. I have personally noticed that everytime I use it I have either diminished effects or none at all despite seeing a big community of people benefiting? I’d always been curious to how it would potentiate opiates if it is using up the enzymes required by the opiate to convert ? I always didn’t get this especially since my antidepressants used to block opiates from working COMPLETELY through an almost identical enzyme issue. Prime example other day 25mg of oxy with no potentiators besides caffeine gave me a strong rush which is a low dose for me also, then today 750mg grapefruit juice, a cup of tonic water and 30mg oxycodone produces very very weak to almost no euphoria at all! I’d love to hear people opinions/debates on this topic as I’m really interested and also if anyone new how long grapefruit and guinine effect the liver enzymes thanks all
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