Opiod conditioning/priming?

[S'wayne]

This is an old thread, and maybe this would be better placed elsewhere, but I thought I'd throw my 2 cents in.

A year or two ago, there was a particularly good type of Kratom around called Red Kalimantan(sometimes with a 2% next to it). I started taking this when I got out of work, tired after a tough day, about ten grams. Well after 20 minutes or so I would fall asleep with the TV on, which is not unusual for me after work. But after taking the Kratom, I would wake up after 30 minutes or so, and just listen to the TV with my eyes still closed. On several oocasions, I started getting waves of euphoria rushing through my body. Totally amazing. Now I know what The Nod™ is and why it is so sought after. But it never would have happened if it weren't for being tired, dosing off, and waking and listening to the TV with my eyes closed. And yeah, I know my tolerance is low(nodding off Kratom?), but it wouldn't happen just sitting there watching TV. This is something special about opies, kind of like a k-hole with ketamine, which has similar requirements, and those that never experience it will never know.

I know it's an old thread, I started it, and though there have been many insightful interesting responses, in my mind and for me it's not resolved. I'm kinda hoping a fresh set of eyes might see it that missed it the first time around, and shed some more light on it. I don't know what Kratom has to do with it, I'm sure it;s not an opioid but I never really checked it out

Perhaps this effect is just with hydrocodone, as I mentioned that is the opioid I have been able to regularly obtain in my days. And I maintain, if I have a small run with opioids for x amount of days, and experience mild acute physical withdrawal symptoms (say I feel like shit for two days clean and wake up feeling decent on the third, after coming off of 30-40mg hydrocodone average daily tapered straight down to 10mg on the last day. Well after a 3 or more day break after re-up, I have many times now taken 40-50 mg hydrocodone expecting it to rock my world, but instead I just get a buzz that doesn't really do it. But reliably, regardless of other outside conditions, on the second or third day back in that dose would surely give me some nice euphoria, as it would if taken in the couple days of feeling like shit with mild withdrawal.

I don't know why it would be like this, it remains a mystery for me.

 

[edzeppelin]

Perhaps this effect is just with hydrocodone, as I mentioned that is the opioid I have been able to regularly obtain in my days. And I maintain, if I have a small run with opioids for x amount of days, and experience mild acute physical withdrawal symptoms (say I feel like shit for two days clean and wake up feeling decent on the third, after coming off of 30-40mg hydrocodone average daily tapered straight down to 10mg on the last day. Well after a 3 or more day break after re-up, I have many times now taken 40-50 mg hydrocodone expecting it to rock my world, but instead I just get a buzz that doesn't really do it. But reliably, regardless of other outside conditions, on the second or third day back in that dose would surely give me some nice euphoria, as it would if taken in the couple days of feeling like shit with mild withdrawal.

I don't know why it would be like this, it remains a mystery for me.

I have taken Hydrocodone for pain, for up to a week at a time, and have experienced something similar. After several days the euphoria becomes much more pronounced. I thought that perhaps pain creates chronic stress, which is relieved in the first couple days. Now your body is destressed, and the Hydro now has a euphoria effect. It's been said that people who take opies for pain relief don't experience much euphoria, but I think that the dose is only enough to relieve pain and reduce chronic stress, not eliminate stress so that you are able to feel euphoria. Make sense? Either that or the build up of Hydro in your system eventually causes euphoria. But it appears you are saying that you get more euphoria by taking smaller doses(relieving stress) so that the third day, whammo - nice euphoria.

This is similar to what I described with me coming home after work and destressing, falling asleep, having no visual sensory input, and having intense euphoria kick in. Read about achieving a nod in other threads. I can't find them right now, but there is discussion along these lines.

 

[S'wayne]

I have taken Hydrocodone for pain, for up to a week at a time, and have experienced something similar. After several days the euphoria becomes much more pronounced. I thought that perhaps pain creates chronic stress, which is relieved in the first couple days. Now your body is destressed, and the Hydro now has a euphoria effect. It's been said that people who take opies for pain relief don't experience much euphoria, but I think that the dose is only enough to relieve pain and reduce chronic stress, not eliminate stress so that you are able to feel euphoria. Make sense? Either that or the build up of Hydro in your system eventually causes euphoria. But it appears you are saying that you get more euphoria by taking smaller doses(relieving stress) so that the third day, whammo - nice euphoria.

This is similar to what I described with me coming home after work and destressing, falling asleep, having no visual sensory input, and having intense euphoria kick in. Read about achieving a nod in other threads. I can't find them right now, but there is discussion along these lines.

Interesting post. I think if you are in serious pain, opioids would have less chance of causing euphoria, as some of the pain would surely "soak it up".....then again narcotic pain medicine doesn't work at the source or block pain, it helps people by muffling or dulling the perception of pain. However the Dr. or nurse will never tell you, if they even know, but quite literally opioids work for pain by making the patient "high", and as the opioid high is, medicine happened to find that it is extremely useful at helping people handle severe pain. Really the patient isn't too concerned and bothered by the pain...because they are high...Now pain management in medicine is funny, seems like sometimes they go low dose, and quite likely it is just enough to keep the pain manageable. Other times they hook the patient up (PCA pump or liberal pain meds), then the patient will be nodding and the like. Probably experiencing much less euphoria than someone else with that dose without pain, however you can tell they are high as hell.

Anyways I wonder if it's particular to hydrocodone.....Does someone who comes off of heroin get that same familiar golden high they are used to the first dose back, or is it not quite "on"

I know it's a totally different drug, but after taking a couple months off of weed, the first time getting high again was almost not fun, very different than the stoning I'm used to.

Now I know if I took a blast of crack cocaine, having been years since I fucked with that shit, I know for sure that would do the trick without any re-introduction....

Someone earlier on in this thread posted dose sensitization, I couldn't find much related to that and opioids on the internet, but perhaps that is the scientific factor behind what I'm experiencing....