I was just thinking about this(I'm at work and am waiting on my dose to take effect if it ever will). The above statement is so true.......if I rock the boat and take even 1mg more for my once every 4 hour dose, then I get a stronger high but can't get a buzz the rest of the day unless I keep taking more. The only way opiates work for my pain is to take 10mg's(hydrocodone) when I get up, and take 10mg's at the 4 hour mark of work and 10 more right before I get off. On the weekends I mess up and take more sometimes and I feel the pain tenfold during the work week.