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Opiate Dos and Don'ts

Benzos and alcohol BEFORE OPIES is a BAD idea even though cause of my tolerance I like to eat XANAX before I shoot DOPE.

In the REALM of potentiation, not too much does it except weed, benzos, MAYBE anti-histamines, and GRAPEFRUIT juice and with that you can only expect so much. It's usually WORTHLESS and psycho-somatic.

SYNERGY and POTENTIATION are TWO seperate things. I think though that the ANTI-HISTAMINE may have a decent amount of truth to it since my boy who's RXed
ridiculous amounts of opies also gets 50 mg. BENADRYLs, but that could be to control itching on the DONES. Which doesn't make too much sense since synthetics tend to not have too much HISTAMINE release...so it sort of points to the possible potentiation of opies by anti-h's.
 
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heres a small clipet:

"Cannabinoid-induced analgesia may be linked to the opioid system because intrathecal THC potentiates morphine-induced analgesia, an effect that is blocked by opioid kappa and delta receptor antagonists in mice.162 Kappa antagonists also block THC-induced spinal analgesia, and cannabinoid agonists and THC increase the spinal release of dynorphins.163-165" -
AMA Council
 
antihistamines DEFINATLY potentiate the nod off opies, as antihisties are sedating. for most people it works very well, creates a better high, and can reduce some bad side effects.
grapefruit DOES work.
 
I always drink a large glass of 100% GF juice and take 1 cimetidine tablet an hour before dosing and it seems to potentiate oxy/H. I never take benzos until after the peak as it destroys euphoria for me.
 
klowns said:
actualy, believe it or not , IT IS PROVEN FACT. just google it, like google morphine and thc or something. ill go find the source if its really that hard to find (which it isnt)
its not just syngery. thc IS KNOWN to make morphine stronger
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i wasnt saying u were wrong just that i didn't think it ws true. all i meant to convey was my opinion, sorry for not being clear. i found an article about it and see that you are correct.
 
Lola'sCola said:
I'm kinda surprised nobody's mentioned the amazing high resulting from a cocaine-opiate combo. (Speedballs, anyone?) Know your tolerance and be smart, and you're in for the ride of a lifetime.

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on that note ive always wondered, is speedballing really hell on your heart?
i mean is that dangerous to do? or its just another thing you gotta be careful with?
in my mind its extremely bad to do for your heart and its easy to OD on.
but thats jus in my mind, and i dont know how i got that mentality towards the speedball, but i jus dont know.

anybody?
 
well i do know that it is common practice even in hospitals to put someone whos on a very large sedating dose of opies: on a small dose of amphetamine. it is considered very safe practice, adn indeeed many people are prescribed amphetamines and opies/and or benzos
now as for a shot of coke and heroin.......................yes you do REALLy should ought to be careful with this. but when done right its beautiful
 
Saucy2040: I'm pretty sure the danger inherent within speedballs directly stems from the increased risk of od'ing on the heroin. That is, if you mix coke and heroin in the same shot and bang it, it isn't until after the rush from the coke has worn off that you realize that you took too much heroin and go straight into an od.

As for being worse for the heart itself, I'm not exactly sure. It would seem logical that cocaine on it's own is worse for the heart since it causes tachychardia, while opiates tend to slow things down - in that sense, heroin might actually counter the negative effects of increased heart-rate caused by cocaine.

This is speculation, though. I'm no expert...
 
yea man, that makes perfect sense, but for some reason i thought that the conflicting effects each drug is tellin your heart to do, would throw it off balance so bad itd stop or jus explode?

or thats too extreme?

i think lacey k could help out on this, she made a thread to clarify what exactly a speedball is. THE REAL SPEEDBALL ;)
 
klowns said:
well i do know that it is common practice even in hospitals to put someone whos on a very large sedating dose of opies: on a small dose of amphetamine. it is considered very safe practice,
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What the fuck kind of hospital does that? Thats a ridiculous practice.
 
^ not that ridiculous. i know of MANY people who are prescribed both benzos + stims or opiates + stims, etc.

and it would make sense if someone is taking lots of morphine a day in a hospital to want to be able to be awake/conscious some of the time (if its a strong dose) so i can understand them giving a patient a stim. so they can be semi-functional. obviously not a huge dose but it wouldn't shock me to hear they give people stim's who are on large drips of strong opiates.
 
^ Me too. Another example is OTC codeine preparations: they often come in tablets including APAP and caffeine. Not a strong stim, but a stim nonetheless... Seems reasonable to me, not ridiculous, to give stims to those on opiates to counter the downer effects.
 
enoughorangejuice? said:
^ seperate b/c coke doesn't need to be heated/cooked like heroin does
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Heroin dont necessarily need to get cooked neither , well not at least out here it dissolves fine w/out cookin the technical def. of speedball is in the same shot.
 
As far as speedballing. Yeah it's the risk from heroin OD that is bad for you. either that or the risk from cocaine OD - you wont feel shitty from a cocaine OD if you're on a buttload of opiates but your heart still will. It's not due to conflicting signals, though. That is a propaganda myth.

Opiate do's - smoke pot, smoke cigarettes, use dxm for a fucking awesome synergy. do mix with mescaline sometime in your life, if you use opiates all the time and ever get the chance, it's the most beautiful thing ever.

Dont - dont mix with massive amounts of meth or hard stimulants - they will kill the buzz. dont drink too much. dont mix cyp2d6 inhibitors (grapefruit and some anticholinergics) with codeine or vicodin. Dont do more than half of your opiate dose if you're doing a good amount of dxm, or you will stop breathing.
 
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chimmpo than tell me why i have rad in numerous medical journals/articles that amphetamine use is common is hospitals when a patient is ovrly sedated all the time. to me it makes 100% sense, and ive read it from Reliable sites so i have no reason to believe that this combo woudl be unsafe (a dose of adderall with a large dose of morphine/lorazepam)
 
someone tell me too, i thought it was suppose to draw the high out from preventing your liver from bearking down the opiate.

ive done it but didnt really notice any difference.
 
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