At 5 pills a day with no pgp inhibitors I think it's safe to say that zero is making it past the BBB and staying there as the only was you can do that without inhibitors is with HUGE doses that overpower pgp.
This is significant because it means all the lope your taking is only having peripheral gut actions and no CNS action.....this means that there isnt really a need to taper it....
Hope that makes sense mate....
Yeah it does make sense, cheers.
In fact it works to my advantage (once again much more by luck than design) as it will make the eventual quit off Lope a whole lot easier and i can also do it much quicker too, like within a week i should think, since it is only having peripheral, but still very important effects imo on my gut.
I didnt bother with the inhibitors simply because i didnt have the energy to get them, but my energy level has improved markedly by today, all together non sensically after having a stim allnighter on Sun but getting a cracking nights sleep last night. I know stim sessions etc are a terrible idea during recovery, i think it may be an issue i need to go back to DS for help with, as i dont seem to have the mental 'tool set' (if you'll forgive the horrible expression / euphemism) to resist them just yet.
But im gonna try leaving out the Clonidine today, expect for at bedtime (the side effect that it makes you very tired and sleepy is very helpful at bedtime but im not gonna abuse it for that reason for too much longer) as the hot/cold/feverish thing along with the non existent energy seem to have gone. I wont speak to soon, but things are looking good atm. :D
So, just to confirm i understand correctly, the Lope wont be helping any with any other opi w/d symptoms without passing the BBB, only gut action?
Btw doesnt it show how much of this stuff can have a placebo effect cos i swear i felt a wave of wellbeing sweep across me every day about 4 hours after taking the Lope, (although the Pregabalin might have been partly helping, although that normally acts far quicker and i didnt really feel much off it, i deliberatley kept my doeses v low, due to fear of another GABA substance addiction) the placebo effect wasnt strong enough to improve the no energy issue, but that would have just been too miraculous and outrageosuly lucky wouldn't it?.

