It is a YMMV thing, period (YMMV = your mileage may vary). From personal experiences i have never had a problem before. I've smoked on SSRIs, Tricyclins, and SNRIs and noticed no difference weather on them or not in terms of the high. However, if you have low tolerance you WILL be more prone to the psychedelics and the effects, but that would not be a huge factor. If you have psychotic breaks or issues along those lines, cannabis could totally throw a wrench in the brain gears. For that reason I cant, nor anyone, really tell you the truth - but if you feel stable, try smoking a little bit and see how that goes. You should be fine, but only experience will say for sure. Have a sitter if you are really worried, the high will not last for a long.
Hoped this helps, we don't really do these types of YMMV threads.
/closed