I have had people who can take astonomical amounts of oxycodone without even feeling good, and im almost positive this person has a strange metabolism, i think he doenst metabolize oxycodone or the others very well and there for doesnt feel much, The solution for this is to take a metabolic enhancer, there are enzymes called cyp2d6 which are responsible for MANY drugs activity, and then therre are enzyme enducers which increase the rate it converts things, blockers that slow it down, and you use one or the other depending on how it gets metabolized, for instance codeine gets metabolized into morphine this way and owes all of its activity to the rate this happens, then you would use an inducer, and there are some such as glutethimide which cause most of it to convert to morphine.
The there are drugs that are destroyed by this metabolism and you want to block the enzyme so it lets the drug stay around to have activity, and in this case you can use something like grapefruit juice, or a few others and it will raises the activity a bit.
ONE NOTE - when you mess around with the systems responsible for this activity you SERIOUSLY run the risk of a huge overdose, i have almost done it as well, i have been using ketamine to remove the tollerance i have and when i use it after taking a normal tollerance amount it almost is way to much.
Just make sure you have the activity changed before you take the drug then you can step up your dose in 10-20mg increments, OH and 20mg should SERIOUSLY rock you once your body gets to using it correctly
have fun
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~The Recreational Pharmacist
Fuck Social, Screw you plur fucks, you dont need a forum for "ELMOvsTELLETUBBIES"
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